FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100096823> ?p ?o ?g. }

• W2100096823 endingPage "326" @default.
• W2100096823 startingPage "319" @default.
• W2100096823 abstract "Abstract Approximately 25 % of clinically important drugs and numerous environmental carcinogens are metabolised by CYP2D6. Variation in the CYP2D6 gene and concomitant use of tamoxifen (TAM) with certain antidepressants may increase recurrence risk in breast cancer patients due to reduced enzyme activity. In this study we determined the appropriateness of adding CYP2D6 genotyping to the breast cancer genetic testing options already available in South Africa, which include BRCA mutation screening and transcriptional profiling to assess estrogen receptor (ER) status. A total of 114 South African breast cancer patients, including 52 Caucasian and 62 Coloured (Mixed ancestry), and 63 Caucasian control individuals were genotyped for the most common inactivating allele (CYP2D6*4, rs3892097) previously identified in the CYP2D6 gene. In the initial validation data set consisting of 25 Caucasian and 62 Coloured patients, the CYP2D6*4 allele frequency was significantly higher in Caucasian compared to Coloured patients (24 % vs. 3 %, p < 0.001), similar to previous findings in the general South African population. Extended CYP2D6 genotyping was subsequently performed in an implementation data set of 27 Caucasian breast cancer patients, to determine the prevalence of depression and use of antidepressants in a clinical setting. A medical history of depression and/or use of antidepressants was reported in 37 % (10/27) of these breast cancer patients genotyped for CYP2D6*4. This translational research study has led to increased awareness among clinicians of the potential benefits of CYP2D6 genotyping to facilitate prevention of cumulative risk in a high-risk genetic subgroup of breast cancer patients considered for concomitant treatment of TAM and antidepressants that may reduce enzyme function." @default.
• W2100096823 created "2016-06-24" @default.
• W2100096823 creator A5004719358 @default.
• W2100096823 creator A5009628160 @default.
• W2100096823 creator A5016650642 @default.
• W2100096823 creator A5033002245 @default.
• W2100096823 creator A5050570294 @default.
• W2100096823 creator A5053195791 @default.
• W2100096823 creator A5076587801 @default.
• W2100096823 date "2012-05-26" @default.
• W2100096823 modified "2023-09-30" @default.
• W2100096823 title "CYP2D6 genotyping and use of antidepressants in breast cancer patients: test development for clinical application" @default.
• W2100096823 cites W1571715768 @default.
• W2100096823 cites W1820658826 @default.
• W2100096823 cites W1976673997 @default.
• W2100096823 cites W1991118471 @default.
• W2100096823 cites W2025801982 @default.
• W2100096823 cites W2047246104 @default.
• W2100096823 cites W2048508323 @default.
• W2100096823 cites W2067324969 @default.
• W2100096823 cites W2076741971 @default.
• W2100096823 cites W2080404498 @default.
• W2100096823 cites W2081510247 @default.
• W2100096823 cites W2081563740 @default.
• W2100096823 cites W2082018761 @default.
• W2100096823 cites W2082160386 @default.
• W2100096823 cites W2084696390 @default.
• W2100096823 cites W2087025655 @default.
• W2100096823 cites W2088346456 @default.
• W2100096823 cites W2094714186 @default.
• W2100096823 cites W2104058573 @default.
• W2100096823 cites W2105365180 @default.
• W2100096823 cites W2110137106 @default.
• W2100096823 cites W2111543120 @default.
• W2100096823 cites W2120384798 @default.
• W2100096823 cites W2127660956 @default.
• W2100096823 cites W2131043327 @default.
• W2100096823 cites W2131530698 @default.
• W2100096823 cites W2138591711 @default.
• W2100096823 cites W2142073070 @default.
• W2100096823 cites W2142696650 @default.
• W2100096823 cites W2147099166 @default.
• W2100096823 cites W2154067964 @default.
• W2100096823 cites W2154444846 @default.
• W2100096823 cites W2157850967 @default.
• W2100096823 cites W2158635723 @default.
• W2100096823 cites W2160431486 @default.
• W2100096823 cites W4232436820 @default.
• W2100096823 cites W4254515792 @default.
• W2100096823 doi "https://doi.org/10.1007/s11011-012-9312-z" @default.
• W2100096823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3505529" @default.
• W2100096823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22638694" @default.
• W2100096823 hasPublicationYear "2012" @default.
• W2100096823 type Work @default.
• W2100096823 sameAs 2100096823 @default.
• W2100096823 citedByCount "10" @default.
• W2100096823 countsByYear W21000968232013 @default.
• W2100096823 countsByYear W21000968232014 @default.
• W2100096823 countsByYear W21000968232015 @default.
• W2100096823 countsByYear W21000968232017 @default.
• W2100096823 countsByYear W21000968232021 @default.
• W2100096823 countsByYear W21000968232022 @default.
• W2100096823 crossrefType "journal-article" @default.
• W2100096823 hasAuthorship W2100096823A5004719358 @default.
• W2100096823 hasAuthorship W2100096823A5009628160 @default.
• W2100096823 hasAuthorship W2100096823A5016650642 @default.
• W2100096823 hasAuthorship W2100096823A5033002245 @default.
• W2100096823 hasAuthorship W2100096823A5050570294 @default.
• W2100096823 hasAuthorship W2100096823A5053195791 @default.
• W2100096823 hasAuthorship W2100096823A5076587801 @default.
• W2100096823 hasBestOaLocation W21000968231 @default.
• W2100096823 hasConcept C104317684 @default.
• W2100096823 hasConcept C121608353 @default.
• W2100096823 hasConcept C126322002 @default.
• W2100096823 hasConcept C135763542 @default.
• W2100096823 hasConcept C143998085 @default.
• W2100096823 hasConcept C153209595 @default.
• W2100096823 hasConcept C166976648 @default.
• W2100096823 hasConcept C2777176818 @default.
• W2100096823 hasConcept C2908647359 @default.
• W2100096823 hasConcept C31467283 @default.
• W2100096823 hasConcept C33664856 @default.
• W2100096823 hasConcept C526171541 @default.
• W2100096823 hasConcept C530470458 @default.
• W2100096823 hasConcept C54355233 @default.
• W2100096823 hasConcept C62231903 @default.
• W2100096823 hasConcept C71924100 @default.
• W2100096823 hasConcept C86803240 @default.
• W2100096823 hasConcept C99454951 @default.
• W2100096823 hasConceptScore W2100096823C104317684 @default.
• W2100096823 hasConceptScore W2100096823C121608353 @default.
• W2100096823 hasConceptScore W2100096823C126322002 @default.
• W2100096823 hasConceptScore W2100096823C135763542 @default.
• W2100096823 hasConceptScore W2100096823C143998085 @default.
• W2100096823 hasConceptScore W2100096823C153209595 @default.
• W2100096823 hasConceptScore W2100096823C166976648 @default.
• W2100096823 hasConceptScore W2100096823C2777176818 @default.
• W2100096823 hasConceptScore W2100096823C2908647359 @default.

• next