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• W2100096876 abstract "Introduccion: en general, los estimulos estresores pueden inducir respuestas adaptativas o mal adaptativasdependiendo, entre otras cosas, de su intensidad y la duracion. Sin embargo, no se han llevado a caboestudios que relacionen cuantitativa y cualitativamente la intensidad de estres al que es expuesto unanimal y la expresion de proteinas del hipocampo. Objetivo: evaluar la expresion diferencial de proteinashipocampales en ratas Wistar-UIS, expuestas a diferentes niveles de estres inducido por el nado forzado.Materiales y metodos: se utilizaron 30 ratas Wistar-UIS machos distribuidas aleatoriamente en 3 grupossegun el tiempo de exposicion al nado forzado como estimulo estresor (0, 5 y 15 minutos). Despues de24 horas se extrajeron los hipocampos dorsales y se realizo electroforesis bidimensional de las proteinasextraidas. A continuacion, se llevo a cabo el procesamiento de las imagenes de los geles obtenidosutilizando el software PDQUEST 2D. Aquellas proteinas en las se detectaron intensidades asociadasa los tiempos de exposicion al estimulo, se identificaron de manera presuntiva utilizando la base dedatos bioinformatica Export Protein Analysis System (EXPASY). Resultados: de acuerdo con el analisisproteomico y bioinformatico se identificaron 60 proteinas, de las cuales, 38 eran comunes al hipocampoderecho e izquierdo; 13 del hipocampo derecho y 9 del izquierdo. Conclusion: se encontraron diferenciasen la expresion de proteinas entre el hipocampo derecho e izquierdo del tipo dosis dependientesdecrecientes despues de haber sometido a los animales a diferentes niveles de estres inducido por laprueba de nado forzado. Salud UIS 2012; 44 (1): 17-27 Palabras clave: Estres, hipocampo, proteomica, nado forzado Introduction: in general stressful stimuli can induce adaptive maladaptive responses, depending among otherthings, of their intensity and duration. However, no studies were found in the literature that link quantitatively andqualitatively the intensity of stress to which an animal is exposed, and hippocampal protein expression. Objective:to evaluate the differential hippocampal protein expression in Wistar-UIS rats, exposed to dissimilar levels ofstress induced by forced swimming. Materials and methods: we used 30 rats randomly assigned to 3 groupsaccording to duration of exposure to forced swimming as stressor stimulus (0, 5 and 15 minutes). 24 hours afterthe dorsal hippocampi were removed and two-dimensional electrophoresis was performed to the extracted proteins.Then, image processing of the gels obtained was performed using the PDQuest 2D software. Those proteins inwhich intensities were detected associated with the stimulus-exposure times were presumptively identified usingExport Protein Analysis System (EXPASY) a bioinformatics database. Results: according to the bioinformaticand proteomic analyses we identified 60 proteins, 38 of which were common to both left and right hippocampi, 13were found only in the right hippocampi and 9 in the left. Conclusion: dose-dependent decreasing rate differencesin protein expression between the left and right hippocampus were found after animals were subjected to differentlevels of stress induced by forced swimming test. Salud UIS 2012; 44 (1): 17-27 Keywords: Stress, hippocampus, proteomic, forced swimming" @default.
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• W2100096876 date "2012-08-29" @default.
• W2100096876 modified "2023-09-26" @default.
• W2100096876 title "Estudio preliminar de la expresión proteómica cerebral de la región hipocampal de ratas expuestas a diferentes niveles de estrés inducido por el nado forzado" @default.
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