FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100097883> ?p ?o ?g. }

• W2100097883 endingPage "4952" @default.
• W2100097883 startingPage "4947" @default.
• W2100097883 abstract "Group I CD1 proteins are specialized antigen-presenting molecules that present both microbial and self lipid antigens to CD1-restricted alpha/beta T lymphocytes. The production of high levels of gamma interferon and lysis of infected macrophages by lipid-specific T lymphocytes are believed to play pivotal roles mainly in the defense against mycobacterial infections. We previously demonstrated that Mycobacterium tuberculosis and bacillus Calmette-Guérin (Mycobacterium bovis BCG) induce human monocytes to differentiate into CD1- dendritic cells (DC), which cannot present lipid antigens to specific T cells. Here, we show that in human monocytes mycobacteria trigger phosphorylation of p38 mitogen-activated protein kinase to inhibit CD1 expression in DC derived from infected monocytes. Pretreatment with a specific p38 inhibitor renders monocytes insensitive to mycobacterial subversion and allows them to differentiate into CD1+ DC, which are fully capable of presenting lipid antigens to specific T cells. We also report that one of the pathogen recognition receptors triggered by BCG to activate p38 is complement receptor 3 (CR3), as shown by reduced p38 phosphorylation and partial reestablishment of CD1 membrane expression obtained by CR3 blockade before infection. In conclusion, we propose that p38 signaling is a novel pathway exploited by mycobacteria to affect the expression of CD1 antigen-presenting cells and avoid immune recognition." @default.
• W2100097883 created "2016-06-24" @default.
• W2100097883 creator A5006408418 @default.
• W2100097883 creator A5008087894 @default.
• W2100097883 creator A5018674182 @default.
• W2100097883 creator A5029852174 @default.
• W2100097883 creator A5030654574 @default.
• W2100097883 creator A5043868737 @default.
• W2100097883 creator A5057056800 @default.
• W2100097883 creator A5062947661 @default.
• W2100097883 creator A5070363854 @default.
• W2100097883 creator A5073974530 @default.
• W2100097883 creator A5079749551 @default.
• W2100097883 date "2009-11-01" @default.
• W2100097883 modified "2023-09-26" @default.
• W2100097883 title "Mycobacteria Exploit p38 Signaling To Affect CD1 Expression and Lipid Antigen Presentation by Human Dendritic Cells" @default.
• W2100097883 cites W1519137759 @default.
• W2100097883 cites W1577886506 @default.
• W2100097883 cites W1587618444 @default.
• W2100097883 cites W1612951701 @default.
• W2100097883 cites W1766534957 @default.
• W2100097883 cites W1811586967 @default.
• W2100097883 cites W1987077580 @default.
• W2100097883 cites W1996230397 @default.
• W2100097883 cites W2003228225 @default.
• W2100097883 cites W2003236719 @default.
• W2100097883 cites W2004440338 @default.
• W2100097883 cites W2009735406 @default.
• W2100097883 cites W2016475905 @default.
• W2100097883 cites W2019306534 @default.
• W2100097883 cites W2024624695 @default.
• W2100097883 cites W2031227424 @default.
• W2100097883 cites W2076272357 @default.
• W2100097883 cites W2077700955 @default.
• W2100097883 cites W2077994279 @default.
• W2100097883 cites W2078100063 @default.
• W2100097883 cites W2080168777 @default.
• W2100097883 cites W2094741883 @default.
• W2100097883 cites W2105935306 @default.
• W2100097883 cites W2112330779 @default.
• W2100097883 cites W2117731866 @default.
• W2100097883 cites W2135662331 @default.
• W2100097883 cites W2151123418 @default.
• W2100097883 cites W2166606605 @default.
• W2100097883 cites W2169339649 @default.
• W2100097883 doi "https://doi.org/10.1128/iai.00607-09" @default.
• W2100097883 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2772541" @default.
• W2100097883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19720761" @default.
• W2100097883 hasPublicationYear "2009" @default.
• W2100097883 type Work @default.
• W2100097883 sameAs 2100097883 @default.
• W2100097883 citedByCount "25" @default.
• W2100097883 countsByYear W21000978832012 @default.
• W2100097883 countsByYear W21000978832014 @default.
• W2100097883 countsByYear W21000978832015 @default.
• W2100097883 countsByYear W21000978832016 @default.
• W2100097883 countsByYear W21000978832017 @default.
• W2100097883 countsByYear W21000978832018 @default.
• W2100097883 countsByYear W21000978832019 @default.
• W2100097883 countsByYear W21000978832021 @default.
• W2100097883 crossrefType "journal-article" @default.
• W2100097883 hasAuthorship W2100097883A5006408418 @default.
• W2100097883 hasAuthorship W2100097883A5008087894 @default.
• W2100097883 hasAuthorship W2100097883A5018674182 @default.
• W2100097883 hasAuthorship W2100097883A5029852174 @default.
• W2100097883 hasAuthorship W2100097883A5030654574 @default.
• W2100097883 hasAuthorship W2100097883A5043868737 @default.
• W2100097883 hasAuthorship W2100097883A5057056800 @default.
• W2100097883 hasAuthorship W2100097883A5062947661 @default.
• W2100097883 hasAuthorship W2100097883A5070363854 @default.
• W2100097883 hasAuthorship W2100097883A5073974530 @default.
• W2100097883 hasAuthorship W2100097883A5079749551 @default.
• W2100097883 hasBestOaLocation W21000978832 @default.
• W2100097883 hasConcept C147483822 @default.
• W2100097883 hasConcept C203014093 @default.
• W2100097883 hasConcept C2776090121 @default.
• W2100097883 hasConcept C37386791 @default.
• W2100097883 hasConcept C67662055 @default.
• W2100097883 hasConcept C83464605 @default.
• W2100097883 hasConcept C86803240 @default.
• W2100097883 hasConcept C8891405 @default.
• W2100097883 hasConcept C89423630 @default.
• W2100097883 hasConcept C95444343 @default.
• W2100097883 hasConceptScore W2100097883C147483822 @default.
• W2100097883 hasConceptScore W2100097883C203014093 @default.
• W2100097883 hasConceptScore W2100097883C2776090121 @default.
• W2100097883 hasConceptScore W2100097883C37386791 @default.
• W2100097883 hasConceptScore W2100097883C67662055 @default.
• W2100097883 hasConceptScore W2100097883C83464605 @default.
• W2100097883 hasConceptScore W2100097883C86803240 @default.
• W2100097883 hasConceptScore W2100097883C8891405 @default.
• W2100097883 hasConceptScore W2100097883C89423630 @default.
• W2100097883 hasConceptScore W2100097883C95444343 @default.
• W2100097883 hasIssue "11" @default.
• W2100097883 hasLocation W21000978831 @default.
• W2100097883 hasLocation W21000978832 @default.
• W2100097883 hasLocation W21000978833 @default.
• W2100097883 hasLocation W21000978834 @default.

• next