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- W2100099564 endingPage "1219" @default.
- W2100099564 startingPage "1205" @default.
- W2100099564 abstract "Fluid resuscitation after massive hemorrhage in major surgery and trauma may result in extensive hemodilution and coagulopathy, which is of a multifactorial nature. Although coagulopathy is often perceived as hemorrhagic, extensive hemodilution affects procoagulants as well as anticoagulant, profibrinolytic, and antifibrinolytic elements, leading to a complex coagulation disorder. Reduced thrombin activation is partially compensated by lower inhibitory activities of antithrombin and other protease inhibitors, whereas plasma fibrinogen is rapidly decreased proportional to the extent of hemodilution. Adequate fibrinogen levels are essential in managing dilutional coagulopathy. After extensive hemodilution, fibrin clots are more prone to fibrinolysis because major antifibrinolytic proteins are decreased.Fresh frozen plasma, platelet concentrate, and cryoprecipitate are considered the mainstay hemostatic therapies. Purified factor concentrates of plasma origin and from recombinant synthesis are increasingly used for a rapid restoration of targeted factors. Future clinical studies are necessary to establish the specific indication, dosing, and safety of novel hemostatic interventions." @default.
- W2100099564 created "2016-06-24" @default.
- W2100099564 creator A5008806595 @default.
- W2100099564 creator A5027454682 @default.
- W2100099564 creator A5050506489 @default.
- W2100099564 creator A5081149773 @default.
- W2100099564 date "2010-11-01" @default.
- W2100099564 modified "2023-10-11" @default.
- W2100099564 title "Pathophysiology and Treatment of Coagulopathy in Massive Hemorrhage and Hemodilution" @default.
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