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• W2100099905 abstract "We report on a series of potent and selective dipeptide fluoromethyl ketone inhibitors of recombinant human calpain I. Compound 4f , having a tetrahydroisoquinoline containing urea motif as N-terminus capping group, is the most potent member ( k obs I = 276,000 M −1 s −1 ) of this class. This compound was shown to prefer calpain I by >36-fold and approximately 4-fold over the related cysteine proteases, cathepsin B and cathepsin L, respectively. Compound 4f is a potent and selective fluoromethyl ketone inhibitor of recombinant human calpain I." @default.
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• W2100099905 date "1996-06-01" @default.
• W2100099905 modified "2023-10-17" @default.
• W2100099905 title "Potent fluoromethyl ketone inhibitors of recombinant human calpain I" @default.
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• W2100099905 doi "https://doi.org/10.1016/0960-894x(96)00209-0" @default.
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