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- W2100104767 abstract "Plan: To synthesize some novel 2-amino thiophenes with various substitutions at 2-amino position for antibacterial and antifungal activity. Prologue : Thiophenes containing organic compounds forms a significant group of drugs which exhibit an array of biological activities like anti-inflammatory, antibacterial, antifungal, anti-neoplastic, antiarthritic etc. Thus a series of new thiophenes have synthesized with various substituents at 2-amino position and screened for antimicrobial activity. Methodology : The parent compound 2-amino-3-(N-furfuryl amido)-4, 5-dimethyl thiophene was synthesized by condensing butan-2-one with furfurylcyano acetamide in presence of sulphur and diethylamine. It was then derivatized to various Schiff bases by reacting with various substituted aromatic aldehydes. The synthesized new compounds were characterized by MP, TLC, IR, NMR and Mass spectra and were screened for their antibacterial and antifungal activity by using Ampicillin and Miconazole nitrate as standard respectively. Outcome : The compounds MAI-2e, MAI-2k, & MAI-2l showed potent antibacterial and MAI-2a, MAI-2c, MAI-2e, & MAI-2f showed potent antifungal activity." @default.
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- W2100104767 date "2012-01-01" @default.
- W2100104767 modified "2023-09-27" @default.
- W2100104767 title "Synthesis and Antimicrobial screening of some Novel Substituted Thiophenes" @default.
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