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- W2100108701 abstract "The Ig H chain locus is regulated by a set of cis-acting elements. Hypersensitive sites (HS) located 3' of the IgH, HS1-4, has been suggested to act as a locus control region (LCR) in cell lines. To assess the proposed role of HS1-4 acting as an LCR, we generated transgenic mice harboring a VH promoter-beta-globin reporter gene linked to the Ig H chain HS1-4 3'regulatory sequences. Transgene expression is strictly confined to B lymphocytes, with no detectable expression outside the B cell lineage in all transgenic founder lines. Furthermore, reporter gene activity is integration independent but not copy number dependent. Thus, additional sequences are required to allow the HS1-4 regulatory region to act as a classical LCR in mice. Our data are discussed in the context of tissue-specific gene expression in B lineage cells." @default.
- W2100108701 created "2016-06-24" @default.
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- W2100108701 date "1999-11-01" @default.
- W2100108701 modified "2023-10-14" @default.
- W2100108701 title "Cutting Edge: Ig Heavy Chain 3′ HS1–4 Directs Correct Spatial Position-Independent Expression of a Linked Transgene to B Lineage Cells" @default.
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- W2100108701 doi "https://doi.org/10.4049/jimmunol.163.9.4637" @default.
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