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• W2100125841 abstract "In the previous studies, we reported that carnosic acid (CA) protects cortical neurons by activating the Keap1/Nrf2 pathway, which activation is initiated by S-alkylation of the critical cysteine thiol of the Keap1 protein by the electrophilicquinone-type CA. Here, we found that the pro-electrophilic CA inhibited the in vitro lipopolysaccharide (LPS)-induced activation of cells of the mouse microglial cell line MG6. LPS induced the expression of IL-1β and IL-6, typical inflammatory cytokines released from microglial cells. CA inhibited the NO production associated with a decrease in the level of inducible NO synthase. Neither CA nor LPS affected cell survival at the concentrations used here. These actions of CA seemed to be mediated by induction of phase 2 genes (gclc, gclm, nqo1 and xct). We propose that an inducer of phase 2 genes may be a critical regulator of microglial activation. Thus, CA is a unique pro-electrophilic compound that provides both a protective effect on neurons and an anti-inflammatory one on microglia through induction of phase 2 genes." @default.
• W2100125841 created "2016-06-24" @default.
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• W2100125841 date "2012-02-01" @default.
• W2100125841 modified "2023-09-27" @default.
• W2100125841 title "Carnosic acid, a pro-electrophilic compound, inhibits LPS-induced activation of microglia" @default.
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• W2100125841 doi "https://doi.org/10.1016/j.bbrc.2011.12.087" @default.
• W2100125841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22214931" @default.
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