Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100147962> ?p ?o ?g. }
- W2100147962 endingPage "556" @default.
- W2100147962 startingPage "548" @default.
- W2100147962 abstract "Summary Protein Z (PZ) is a vitamin K-dependent factor identified in human plasma in 1984 characterized by an homology with other vitamin K-dependent factors (factor VII, IX, X, protein C). In contrast to these factors, PZ does not possess any enzymatic activity but is involved as a cofactor in the down-regulation of coagulation by forming a complex with the protein Z-dependent protease inhibitor (ZPI). ZPI inhibits the activated factor X (FXa) on phospholipid surface. In mice, the disruption of PZ gene is asymptomatic, but the association with the factor V Leiden mutation leads to a quasi complete mortality during the neonatal period with microvascular thrombosis. In humans, PZ is characterized by an unusual wide distribution in plasma, and a major decrease induced by warfarin. Isolated PZ deficiency does not seem to constitute a risk for venous thrombosis, but a severe PZ deficiency could increase the risk of well recognized venous thrombotic risk factors such as factor V Leiden, G20210A mutation or hyperhomocysteinemia. Unexpectedly, a relationship between PZ deficiency and ischemic arterial diseases such as stroke, acute coronary syndromes or peripheral arterial disease was described but not confirmed by all studies. PZ deficiency could be also a risk factor for early fetal losses, and increases the arterial risk in antiphospholipid syndrome. This review analyzes the different studies so far published and discusses the various results obtained in order to understand whether or not protein Z deficiency could be considered as an arterial ischemic risk factor." @default.
- W2100147962 created "2016-06-24" @default.
- W2100147962 creator A5005491582 @default.
- W2100147962 date "2008-01-01" @default.
- W2100147962 modified "2023-09-25" @default.
- W2100147962 title "Protein Z, a protein seeking a pathology" @default.
- W2100147962 cites W1038329301 @default.
- W2100147962 cites W1479935039 @default.
- W2100147962 cites W1487214646 @default.
- W2100147962 cites W1537891220 @default.
- W2100147962 cites W1541757002 @default.
- W2100147962 cites W1553661178 @default.
- W2100147962 cites W1559610250 @default.
- W2100147962 cites W1563243664 @default.
- W2100147962 cites W1595226937 @default.
- W2100147962 cites W1600057174 @default.
- W2100147962 cites W16659746 @default.
- W2100147962 cites W1671460938 @default.
- W2100147962 cites W1880693302 @default.
- W2100147962 cites W1904738311 @default.
- W2100147962 cites W1923571998 @default.
- W2100147962 cites W1963815811 @default.
- W2100147962 cites W1965204618 @default.
- W2100147962 cites W1970161238 @default.
- W2100147962 cites W1974860017 @default.
- W2100147962 cites W1975881881 @default.
- W2100147962 cites W1976354843 @default.
- W2100147962 cites W1976501531 @default.
- W2100147962 cites W1978524519 @default.
- W2100147962 cites W1979248947 @default.
- W2100147962 cites W1979604095 @default.
- W2100147962 cites W1981419326 @default.
- W2100147962 cites W1984542574 @default.
- W2100147962 cites W1986336995 @default.
- W2100147962 cites W1988577178 @default.
- W2100147962 cites W1988804389 @default.
- W2100147962 cites W1989430469 @default.
- W2100147962 cites W1991380170 @default.
- W2100147962 cites W1992744004 @default.
- W2100147962 cites W1993046950 @default.
- W2100147962 cites W1996675508 @default.
- W2100147962 cites W1997136072 @default.
- W2100147962 cites W2003384516 @default.
- W2100147962 cites W2006867193 @default.
- W2100147962 cites W2010596416 @default.
- W2100147962 cites W2013279581 @default.
- W2100147962 cites W2020398904 @default.
- W2100147962 cites W2021392301 @default.
- W2100147962 cites W2023370493 @default.
- W2100147962 cites W2024563443 @default.
- W2100147962 cites W2027597595 @default.
- W2100147962 cites W2029369465 @default.
- W2100147962 cites W2032677469 @default.
- W2100147962 cites W2035280958 @default.
- W2100147962 cites W2036030218 @default.
- W2100147962 cites W2036265066 @default.
- W2100147962 cites W2037679157 @default.
- W2100147962 cites W2037992541 @default.
- W2100147962 cites W2038730936 @default.
- W2100147962 cites W2039774822 @default.
- W2100147962 cites W2041994248 @default.
- W2100147962 cites W2043108703 @default.
- W2100147962 cites W2045995666 @default.
- W2100147962 cites W2049133091 @default.
- W2100147962 cites W2053773033 @default.
- W2100147962 cites W2053868883 @default.
- W2100147962 cites W2056640345 @default.
- W2100147962 cites W2057290382 @default.
- W2100147962 cites W2057616303 @default.
- W2100147962 cites W2063339140 @default.
- W2100147962 cites W2064987448 @default.
- W2100147962 cites W2067622046 @default.
- W2100147962 cites W2068354138 @default.
- W2100147962 cites W2072361200 @default.
- W2100147962 cites W2074360476 @default.
- W2100147962 cites W2074509233 @default.
- W2100147962 cites W2076460162 @default.
- W2100147962 cites W2082851545 @default.
- W2100147962 cites W2083303730 @default.
- W2100147962 cites W2083426924 @default.
- W2100147962 cites W2087823848 @default.
- W2100147962 cites W2088121021 @default.
- W2100147962 cites W2088189362 @default.
- W2100147962 cites W2090483169 @default.
- W2100147962 cites W2093012142 @default.
- W2100147962 cites W2093267315 @default.
- W2100147962 cites W2094509219 @default.
- W2100147962 cites W2115261936 @default.
- W2100147962 cites W2120265067 @default.
- W2100147962 cites W2125717333 @default.
- W2100147962 cites W2128788780 @default.
- W2100147962 cites W2140575156 @default.
- W2100147962 cites W2157079749 @default.
- W2100147962 cites W2166135387 @default.
- W2100147962 cites W2213002076 @default.
- W2100147962 cites W2228969017 @default.
- W2100147962 cites W2271925234 @default.
- W2100147962 cites W2314907166 @default.