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• W2100150770 startingPage "1774" @default.
• W2100150770 abstract "<b>Background and aims:</b> Hydrophobic bile acids contribute to hepatocellular injury in cholestasis and rapidly induce apoptosis in vitro; however, unlike Fas agonists, cholestasis does not cause extensive hepatocyte apoptosis. As antioxidants provide protection against bile acid induced liver injury, our premise was that bilirubin, a free radical scavenger with increased plasma levels in the presence of liver disease, could protect hepatocytes against bile acid induced apoptosis. <b>Methods:</b> Freshly isolated rat hepatocytes were incubated for four hours with 100 μmol/l glycochenodeoxycholate (GCDC) alone or with increasing concentrations of unconjugated (UCB) or conjugated (CB) bilirubin. <b>Results:</b> Both UCB and CB inhibited GCDC induced apoptosis in a dose dependent fashion and suppressed the generation of reactive oxygen species by hepatocytes. <b>Conclusions:</b> The antiapoptotic effect of bilirubin associated with its antioxidant properties indicates that hyperbilirubinaemia may have a protective role in liver disease." @default.
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• W2100150770 date "2003-12-01" @default.
• W2100150770 modified "2023-09-23" @default.
• W2100150770 title "Bilirubin inhibits bile acid induced apoptosis in rat hepatocytes" @default.
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• W2100150770 doi "https://doi.org/10.1136/gut.52.12.1774" @default.
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