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• W2100151647 endingPage "1825" @default.
• W2100151647 startingPage "1812" @default.
• W2100151647 abstract "T cell expression of inhibitory proteins can be a critical component for the regulation of immunopathology owing to self-reactivity or potentially exuberant responses to pathogens, but it may also limit T cell responses to some malignancies, particularly if the tumor Ag being targeted is a self-protein. We found that the abrogation of Src homology region 2 domain-containing phosphatase-1 (SHP-1) in tumor-reactive CD8(+) T cells improves the therapeutic outcome of adoptive immunotherapy in a mouse model of disseminated leukemia, with benefit observed in therapy employing transfer of CD8(+) T cells alone or in the context of also providing supplemental IL-2. SHP-1(-/-) and SHP-1(+/+) effector T cells were expanded in vitro for immunotherapy. Following transfer in vivo, the SHP-1(-/-) effector T cells exhibited enhanced short-term accumulation, followed by greater contraction, and they ultimately formed similar numbers of long-lived, functional memory cells. The increased therapeutic effectiveness of SHP-1(-/-) effector cells was also observed in recipients that expressed the tumor Ag as a self-antigen in the liver, without evidence of inducing autoimmune toxicity. SHP-1(-/-) effector CD8(+) T cells expressed higher levels of eomesodermin, which correlated with enhanced lysis of tumor cells. Furthermore, reduction of SHP-1 expression in tumor-reactive effector T cells by retroviral transduction with vectors that express SHP-1-specific small interfering RNA, a translatable strategy, also exhibited enhanced antitumor activity in vivo. These studies suggest that abrogating SHP-1 in effector T cells may improve the efficacy of tumor elimination by T cell therapy without affecting the ability of the effector cells to persist and provide a long-term response." @default.
• W2100151647 created "2016-06-24" @default.
• W2100151647 creator A5012791367 @default.
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• W2100151647 creator A5081170148 @default.
• W2100151647 date "2012-07-13" @default.
• W2100151647 modified "2023-10-12" @default.
• W2100151647 title "Abrogation of Src Homology Region 2 Domain-Containing Phosphatase 1 in Tumor-Specific T Cells Improves Efficacy of Adoptive Immunotherapy by Enhancing the Effector Function and Accumulation of Short-Lived Effector T Cells In Vivo" @default.
• W2100151647 cites W1509560407 @default.
• W2100151647 cites W1569766809 @default.
• W2100151647 cites W1571861420 @default.
• W2100151647 cites W1578040179 @default.
• W2100151647 cites W1600077057 @default.
• W2100151647 cites W1839765230 @default.
• W2100151647 cites W1888826009 @default.
• W2100151647 cites W1906616494 @default.
• W2100151647 cites W1964077677 @default.
• W2100151647 cites W1969318766 @default.
• W2100151647 cites W1971692004 @default.
• W2100151647 cites W1973746992 @default.
• W2100151647 cites W1974559250 @default.
• W2100151647 cites W1975962380 @default.
• W2100151647 cites W1982226677 @default.
• W2100151647 cites W1983412131 @default.
• W2100151647 cites W1984927242 @default.
• W2100151647 cites W1985200577 @default.
• W2100151647 cites W1985294654 @default.
• W2100151647 cites W1985889257 @default.
• W2100151647 cites W1986102510 @default.
• W2100151647 cites W1993948601 @default.
• W2100151647 cites W1994815971 @default.
• W2100151647 cites W1994872258 @default.
• W2100151647 cites W1996117550 @default.
• W2100151647 cites W1996521528 @default.
• W2100151647 cites W1998652423 @default.
• W2100151647 cites W2001739592 @default.
• W2100151647 cites W2015376574 @default.
• W2100151647 cites W2016671320 @default.
• W2100151647 cites W2016840028 @default.
• W2100151647 cites W2017582048 @default.
• W2100151647 cites W2020920166 @default.
• W2100151647 cites W2030005722 @default.
• W2100151647 cites W2036408747 @default.
• W2100151647 cites W2047577853 @default.
• W2100151647 cites W2064718707 @default.
• W2100151647 cites W2068046103 @default.
• W2100151647 cites W2070770310 @default.
• W2100151647 cites W2075121503 @default.
• W2100151647 cites W2078315546 @default.
• W2100151647 cites W2082742146 @default.
• W2100151647 cites W2084065981 @default.
• W2100151647 cites W2088165891 @default.
• W2100151647 cites W2089027973 @default.
• W2100151647 cites W2092354039 @default.
• W2100151647 cites W2094652659 @default.
• W2100151647 cites W2094945699 @default.
• W2100151647 cites W2095224412 @default.
• W2100151647 cites W2095547255 @default.
• W2100151647 cites W2099887519 @default.
• W2100151647 cites W2108108310 @default.
• W2100151647 cites W2108578856 @default.
• W2100151647 cites W2109627278 @default.
• W2100151647 cites W2109844028 @default.
• W2100151647 cites W2110459643 @default.
• W2100151647 cites W2110932366 @default.
• W2100151647 cites W2112888403 @default.
• W2100151647 cites W2113091360 @default.
• W2100151647 cites W2114399922 @default.
• W2100151647 cites W2115283797 @default.
• W2100151647 cites W2119319172 @default.
• W2100151647 cites W2124373740 @default.
• W2100151647 cites W2129997470 @default.
• W2100151647 cites W2130506153 @default.
• W2100151647 cites W2133064156 @default.
• W2100151647 cites W2133560683 @default.
• W2100151647 cites W2138105454 @default.
• W2100151647 cites W2140848655 @default.
• W2100151647 cites W2143899077 @default.
• W2100151647 cites W2148300725 @default.
• W2100151647 cites W2148523692 @default.
• W2100151647 cites W2156587144 @default.
• W2100151647 cites W2160950337 @default.
• W2100151647 cites W2161479825 @default.
• W2100151647 cites W2162743131 @default.
• W2100151647 cites W2162815046 @default.
• W2100151647 cites W2164364292 @default.
• W2100151647 cites W2165652595 @default.
• W2100151647 cites W2167441884 @default.
• W2100151647 cites W2167550136 @default.
• W2100151647 cites W2169004603 @default.

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