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- W2100154032 endingPage "fnv146" @default.
- W2100154032 startingPage "fnv146" @default.
- W2100154032 abstract "This study investigated multidrug resistance in Shewanella xiamenensis isolated from an estuarine water sample in China during 2014. This strain displayed resistance or decreased susceptibility to ampicillin, aztreonam, cefepime, cefotaxime, chloramphenicol, ciprofloxacin, erythromycin, kanamycin and trimethoprim-sulfamethoxazole. The antimicrobial resistance genes aacA3, blaOXA-199, qnrA1 and sul1 were identified by PCR amplification and by sequencing. Pulsed-field gel electrophoresis and DNA hybridization experiments showed that the quinolone resistance gene qnrA1 was chromosomally located. qnrA1 was located in a complex class 1 integron, downstream from an ISCR1, and bracketed by two copies of qacEΔ1-sul1 genes. This integron is similar to In825 with four gene cassettes aacA3, catB11c, dfrA1z and aadA2az. An IS26-mel-mph2-IS26 structure was also detected in the flanking sequences, conferring resistance to macrolides. This is the first identification of the class 1 integron in S. xiamenensis. This is also the first identification of the qnrA1 gene and IS26-mediated macrolide resistance genes in S. xiamenensis. Presence of a variety of resistance genetic determinants in environmental S. xiamenensis suggests the possibility that this species may serve as a potential vehicle of antimicrobial resistance genes in aquatic environments." @default.
- W2100154032 created "2016-06-24" @default.
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- W2100154032 date "2015-08-26" @default.
- W2100154032 modified "2023-10-18" @default.
- W2100154032 title "Identification of an integron containing the quinolone resistance gene<i>qnrA1</i>in<i>Shewanella xiamenensis</i>" @default.
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- W2100154032 doi "https://doi.org/10.1093/femsle/fnv146" @default.
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