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• W2100154584 abstract "This study examined the e f fe~ t s~of aging on the rnyoc&dial protein content of Glut 4, Glut 1, insulin receptor, IGF-1 receptor, and PI3 kinase of the C57B1/6 mouse. Insulin and IGF-I receptor a~ to~hospho iy l a t i on activity was also assessed. Glut 4 content was increased fourfold between 22.5 and 29 mo. of age, as compared to 5 mo. animals. Glut 1 content was increased by 40% at 17 mo., returning to 5 mo. levels at 29 mo. Insulin and IGF-1 receptor ccintent decreased early between 5 and 17 mo. by 20-io 35%, and remained constant until 29 mo. and 25 mo. respectively. Between 25 and 29 mo., IGF-1 protein levels decreased to 24'2) of 5 mo. control. Receptor autophosphorylation was increased at basal and maximally stimulating (10-6 M) concentrations of -3% insulin or ICF-I by two to fourfold. PI3 kinase content decreased 3(1'X, by 12 mo. and remained constant thereafter. We conclude that the components of the myocardial glucose transport system studied here are upregulated with advancing age in accordance to the increased importance of cardiac glucose metabolism with aging." @default.
• W2100154584 created "2016-06-24" @default.
• W2100154584 creator A5027851935 @default.
• W2100154584 date "1997-01-01" @default.
• W2100154584 modified "2023-09-27" @default.
• W2100154584 title "MYOCARDIAL GLUCOSE TRANSPORT SYSTEM RELATED PROTEINS: THE EFFECTS OF AGING AND EXERCISE IN OLD MICE" @default.
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