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• W2100156742 abstract "We have carried out a prospective, randomized controlled trial of perioperative prophylaxis with cefuroxime and piperacillin in 53 recipients of renal allografts. Twenty-seven patients received antibiotic prophylaxis with three doses of cefuroxime 750 mg and piperacillin 4 g, and 26 patients received no prophylaxis. Risk factors for infection were well matched. Infection rates were analysed for the periods 0–5 days and 0–14 days post-transplant. In the first 5 days, patients receiving antibiotics had fewer infections (3 vs. 11, P = 0·04) but by 14 days this difference was no longer apparent (21 vs. 30, P = NS). There was a total of 15 wound infections, which were more common in the control group both at 5 days (1 vs. 5, P= NS) and at 14 days (4 vs. 11, P = 0·027). Urinary infections were unaffected by prophylaxis. We conclude that perioperative antibiotic prophylaxis results in a modest but worthwhile reduction in the incidence of wound infections after renal transplantation." @default.
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• W2100156742 date "1988-05-01" @default.
• W2100156742 modified "2023-09-28" @default.
• W2100156742 title "A prospective randomized controlled trial of perioperative antibiotic prophylaxis in renal transplantation" @default.
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• W2100156742 doi "https://doi.org/10.1016/0195-6701(88)90089-8" @default.
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