FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100157401> ?p ?o ?g. }

• W2100157401 endingPage "50" @default.
• W2100157401 startingPage "5443" @default.
• W2100157401 abstract "Cells derived from the G-subline of the Dunning R-3327 rat prostatic adenocarcinoma were selected on the basis of their inducibility for alkaline phosphatase (AP) activity by retinoic acid. A p-nitrophenylphosphate-agarose overlay procedure was used to identify AP-inducible clones. The frequency of AP-inducible cells in one rapidly growing tumorigenic clone, designated 9-1C, has remained at 100% during at least 4 months of continuous culture. In culture, 9-1C cells had a mean population-doubling time in log phase of 14 hr. Retinoic acid (10 microM) did not significantly affect the rate of growth in log phase. It did, however, cause the cultures to saturate at a cell density which was 40% lower than that of control cultures. This effect on saturation density was reversible within 24 hr after removing retinoic acid from the medium. Retinoic acid-treated cells occupied greater areas on the culture dish surface, and the cross-sectional area of these cells, measured on dispersed cells by light-scatter flow cytometry, was 35 to 40% greater than that of control cells. The inducibility of 9-1C cells for AP activity decreased as the culture density increased. Cells of the 9-1C clone produced tumors when injected into male and female Fischer X Copenhagen F1 rats. No histological differences were detected between tumors grown in male and female rats. Although the tumors were poorly differentiated, primitive acinar-like structures were observed. Cells staining uniformly positive for AP activity were distributed randomly throughout the tumors. In the acinar-like structures, AP activity was localized only on the apical surfaces of the cells lining the lumens. This was also the site of enzyme activity in acini of the lateral component of the dorsolateral prostate, the source of the original R-3327 tumor. In the lateral prostatic component, AP activity was also found in the basal region of the acini, and the secretory material filling the lumens was strongly positive for the enzyme. These two regions of the tumor acini were negative for AP activity. With the exception of activity in capillaries at the basal surface, the acini of the dorsal component of the dorsolateral prostate were devoid of AP activity." @default.
• W2100157401 created "2016-06-24" @default.
• W2100157401 creator A5001918888 @default.
• W2100157401 creator A5003204203 @default.
• W2100157401 creator A5007553347 @default.
• W2100157401 creator A5029640167 @default.
• W2100157401 creator A5055169056 @default.
• W2100157401 creator A5069010224 @default.
• W2100157401 creator A5077758847 @default.
• W2100157401 date "1983-11-01" @default.
• W2100157401 modified "2023-09-23" @default.
• W2100157401 title "Effect of retinoic acid on the growth and morphology of a prostatic adenocarcinoma cell line cloned for the retinoid inducibility of alkaline phosphatase." @default.
• W2100157401 cites W1513377274 @default.
• W2100157401 cites W1599231504 @default.
• W2100157401 cites W1965654870 @default.
• W2100157401 cites W1971061851 @default.
• W2100157401 cites W1990740831 @default.
• W2100157401 cites W1996142715 @default.
• W2100157401 cites W1997195640 @default.
• W2100157401 cites W2009000096 @default.
• W2100157401 cites W2010193721 @default.
• W2100157401 cites W2018650295 @default.
• W2100157401 cites W2030118676 @default.
• W2100157401 cites W2034118875 @default.
• W2100157401 cites W2041645428 @default.
• W2100157401 cites W2046171723 @default.
• W2100157401 cites W2060464465 @default.
• W2100157401 cites W2083049276 @default.
• W2100157401 cites W2091856195 @default.
• W2100157401 cites W2111086908 @default.
• W2100157401 cites W2280715110 @default.
• W2100157401 cites W229214304 @default.
• W2100157401 cites W2322776397 @default.
• W2100157401 cites W237310793 @default.
• W2100157401 cites W2409671375 @default.
• W2100157401 cites W2415171519 @default.
• W2100157401 cites W274463353 @default.
• W2100157401 cites W2102798251 @default.
• W2100157401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6616477" @default.
• W2100157401 hasPublicationYear "1983" @default.
• W2100157401 type Work @default.
• W2100157401 sameAs 2100157401 @default.
• W2100157401 citedByCount "5" @default.
• W2100157401 countsByYear W21001574012014 @default.
• W2100157401 crossrefType "journal-article" @default.
• W2100157401 hasAuthorship W2100157401A5001918888 @default.
• W2100157401 hasAuthorship W2100157401A5003204203 @default.
• W2100157401 hasAuthorship W2100157401A5007553347 @default.
• W2100157401 hasAuthorship W2100157401A5029640167 @default.
• W2100157401 hasAuthorship W2100157401A5055169056 @default.
• W2100157401 hasAuthorship W2100157401A5069010224 @default.
• W2100157401 hasAuthorship W2100157401A5077758847 @default.
• W2100157401 hasConcept C104317684 @default.
• W2100157401 hasConcept C126322002 @default.
• W2100157401 hasConcept C134018914 @default.
• W2100157401 hasConcept C1491633281 @default.
• W2100157401 hasConcept C153911025 @default.
• W2100157401 hasConcept C160160445 @default.
• W2100157401 hasConcept C181199279 @default.
• W2100157401 hasConcept C2775954498 @default.
• W2100157401 hasConcept C2779963572 @default.
• W2100157401 hasConcept C2781121885 @default.
• W2100157401 hasConcept C2908647359 @default.
• W2100157401 hasConcept C48900799 @default.
• W2100157401 hasConcept C54355233 @default.
• W2100157401 hasConcept C55493867 @default.
• W2100157401 hasConcept C62112901 @default.
• W2100157401 hasConcept C71924100 @default.
• W2100157401 hasConcept C81089528 @default.
• W2100157401 hasConcept C81885089 @default.
• W2100157401 hasConcept C86803240 @default.
• W2100157401 hasConcept C99454951 @default.
• W2100157401 hasConceptScore W2100157401C104317684 @default.
• W2100157401 hasConceptScore W2100157401C126322002 @default.
• W2100157401 hasConceptScore W2100157401C134018914 @default.
• W2100157401 hasConceptScore W2100157401C1491633281 @default.
• W2100157401 hasConceptScore W2100157401C153911025 @default.
• W2100157401 hasConceptScore W2100157401C160160445 @default.
• W2100157401 hasConceptScore W2100157401C181199279 @default.
• W2100157401 hasConceptScore W2100157401C2775954498 @default.
• W2100157401 hasConceptScore W2100157401C2779963572 @default.
• W2100157401 hasConceptScore W2100157401C2781121885 @default.
• W2100157401 hasConceptScore W2100157401C2908647359 @default.
• W2100157401 hasConceptScore W2100157401C48900799 @default.
• W2100157401 hasConceptScore W2100157401C54355233 @default.
• W2100157401 hasConceptScore W2100157401C55493867 @default.
• W2100157401 hasConceptScore W2100157401C62112901 @default.
• W2100157401 hasConceptScore W2100157401C71924100 @default.
• W2100157401 hasConceptScore W2100157401C81089528 @default.
• W2100157401 hasConceptScore W2100157401C81885089 @default.
• W2100157401 hasConceptScore W2100157401C86803240 @default.
• W2100157401 hasConceptScore W2100157401C99454951 @default.
• W2100157401 hasIssue "11" @default.
• W2100157401 hasLocation W21001574011 @default.
• W2100157401 hasOpenAccess W2100157401 @default.
• W2100157401 hasPrimaryLocation W21001574011 @default.
• W2100157401 hasRelatedWork W1575302432 @default.
• W2100157401 hasRelatedWork W1975648175 @default.

• next