FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100159981> ?p ?o ?g. }

• W2100159981 endingPage "1187" @default.
• W2100159981 startingPage "1174" @default.
• W2100159981 abstract "BACKGROUND: The dosing of drugs in patients with kidney dysfunction is often based on the estimates of kidney function. OBJECTIVE: To systematically compare the performance of the Modification of Diet in Renal Disease (MDRD) and Cockcroft-Gault (CG) equations for dosage adjustment. METHODS: We assessed agreement (concordance, kappa statistics [κ,κ ω ]) between CG and MDRD using a Food and Drug Administration database to evaluate the effect of renal function on the pharmacokinetics of 36 approved drugs. Across the approved drugs, we compared the correlation between these 2 equations for renal drug clearance (Cl ren ) and area under the concentration-time curve. For 26 approved drugs that require renal dose adjustment, we also compared dosing regimens and expected exposure using these equations. Sensitivity analyses were performed by adjusting the MDRD estimates for individualized body surface area and/or range of serum creatinine assay calibration errors. RESULTS: In the pharmacokinetic database with 973 subjects (age 18-95 years, weight 35-153 kg, female 33%), we found that the CG and the MDRD classification of renal function generally agreed (64.2%, κ = 0.54, κ ω = 0.73). Among the subjects studied for drugs requiring renal dose adjustment, dosages in 12% were changed to a higher or lower dosing category by the MDRD compared to the CG equation. In particular, using MDRD in place of CG for dosage modification yielded higher dosing recommendations for subjects with a combination of age >80 years, weight <55 kg, and serum creatinine >0.7 and ≤1.5 mg/dL; the coefficient of determination was also higher by CG than MDRD in trials that enrolled these or similar patients. CONCLUSIONS: For patients with advanced age, low weight, and modestly elevated serum creatinine, further work is needed before the MDRD equations can replace the CG equation for dose adjustment in the labeling." @default.
• W2100159981 created "2016-06-24" @default.
• W2100159981 creator A5009950539 @default.
• W2100159981 creator A5023187687 @default.
• W2100159981 creator A5031880378 @default.
• W2100159981 creator A5046903734 @default.
• W2100159981 creator A5047881617 @default.
• W2100159981 creator A5056609564 @default.
• W2100159981 creator A5057284288 @default.
• W2100159981 creator A5072443467 @default.
• W2100159981 creator A5072539709 @default.
• W2100159981 creator A5081002875 @default.
• W2100159981 creator A5083613074 @default.
• W2100159981 date "2012-09-01" @default.
• W2100159981 modified "2023-09-26" @default.
• W2100159981 title "A Systematic Comparison of Cockcroft-Gault and Modification of Diet in Renal Disease Equations for Classification of Kidney Dysfunction and Dosage Adjustment" @default.
• W2100159981 cites W1267113676 @default.
• W2100159981 cites W133504488 @default.
• W2100159981 cites W1840746889 @default.
• W2100159981 cites W1971445485 @default.
• W2100159981 cites W1996377151 @default.
• W2100159981 cites W2036943934 @default.
• W2100159981 cites W2049258903 @default.
• W2100159981 cites W2065570335 @default.
• W2100159981 cites W2067698244 @default.
• W2100159981 cites W2079460699 @default.
• W2100159981 cites W2089526947 @default.
• W2100159981 cites W2099266299 @default.
• W2100159981 cites W2102398998 @default.
• W2100159981 cites W2115365178 @default.
• W2100159981 cites W2123653031 @default.
• W2100159981 cites W2127247627 @default.
• W2100159981 cites W2127790911 @default.
• W2100159981 cites W2131672675 @default.
• W2100159981 cites W2135419594 @default.
• W2100159981 cites W2146841626 @default.
• W2100159981 cites W2150290224 @default.
• W2100159981 cites W2150915230 @default.
• W2100159981 cites W2156074664 @default.
• W2100159981 cites W2168339213 @default.
• W2100159981 doi "https://doi.org/10.1345/aph.1q757" @default.
• W2100159981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22932303" @default.
• W2100159981 hasPublicationYear "2012" @default.
• W2100159981 type Work @default.
• W2100159981 sameAs 2100159981 @default.
• W2100159981 citedByCount "48" @default.
• W2100159981 countsByYear W21001599812012 @default.
• W2100159981 countsByYear W21001599812013 @default.
• W2100159981 countsByYear W21001599812014 @default.
• W2100159981 countsByYear W21001599812015 @default.
• W2100159981 countsByYear W21001599812016 @default.
• W2100159981 countsByYear W21001599812017 @default.
• W2100159981 countsByYear W21001599812018 @default.
• W2100159981 countsByYear W21001599812019 @default.
• W2100159981 countsByYear W21001599812020 @default.
• W2100159981 countsByYear W21001599812021 @default.
• W2100159981 crossrefType "journal-article" @default.
• W2100159981 hasAuthorship W2100159981A5009950539 @default.
• W2100159981 hasAuthorship W2100159981A5023187687 @default.
• W2100159981 hasAuthorship W2100159981A5031880378 @default.
• W2100159981 hasAuthorship W2100159981A5046903734 @default.
• W2100159981 hasAuthorship W2100159981A5047881617 @default.
• W2100159981 hasAuthorship W2100159981A5056609564 @default.
• W2100159981 hasAuthorship W2100159981A5057284288 @default.
• W2100159981 hasAuthorship W2100159981A5072443467 @default.
• W2100159981 hasAuthorship W2100159981A5072539709 @default.
• W2100159981 hasAuthorship W2100159981A5081002875 @default.
• W2100159981 hasAuthorship W2100159981A5083613074 @default.
• W2100159981 hasConcept C105795698 @default.
• W2100159981 hasConcept C112705442 @default.
• W2100159981 hasConcept C126322002 @default.
• W2100159981 hasConcept C126894567 @default.
• W2100159981 hasConcept C159641895 @default.
• W2100159981 hasConcept C160798450 @default.
• W2100159981 hasConcept C162156334 @default.
• W2100159981 hasConcept C2777288759 @default.
• W2100159981 hasConcept C2777501473 @default.
• W2100159981 hasConcept C2778653478 @default.
• W2100159981 hasConcept C2780306776 @default.
• W2100159981 hasConcept C2781059462 @default.
• W2100159981 hasConcept C33923547 @default.
• W2100159981 hasConcept C71924100 @default.
• W2100159981 hasConceptScore W2100159981C105795698 @default.
• W2100159981 hasConceptScore W2100159981C112705442 @default.
• W2100159981 hasConceptScore W2100159981C126322002 @default.
• W2100159981 hasConceptScore W2100159981C126894567 @default.
• W2100159981 hasConceptScore W2100159981C159641895 @default.
• W2100159981 hasConceptScore W2100159981C160798450 @default.
• W2100159981 hasConceptScore W2100159981C162156334 @default.
• W2100159981 hasConceptScore W2100159981C2777288759 @default.
• W2100159981 hasConceptScore W2100159981C2777501473 @default.
• W2100159981 hasConceptScore W2100159981C2778653478 @default.
• W2100159981 hasConceptScore W2100159981C2780306776 @default.
• W2100159981 hasConceptScore W2100159981C2781059462 @default.
• W2100159981 hasConceptScore W2100159981C33923547 @default.
• W2100159981 hasConceptScore W2100159981C71924100 @default.
• W2100159981 hasIssue "9" @default.
• W2100159981 hasLocation W21001599811 @default.

• next