FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100163911> ?p ?o ?g. }

• W2100163911 abstract "The authors thank Dr Raymond J. Proudlock for his comments on their article. First, studies on the genotoxicity of lead salt are inconclusive. Pelclova et al. (1) did not detect a significant increase in structural aberrations (chromosome and chromatid exchanges, and breaks) in 22 workers from a lead battery plant. In contrast, Vaglenov et al. (2) found a significant increase in MN frequency among the lead-exposed staff (millers and assemblers) of a battery plant. The etiology of lead genotoxicity and carcinogenicity is complex. In vitro studies have demonstrated that lead interacts with proteins and nucleic acids, particularly at the sulfhydryl group and the phosphate backbone, respectively (3,4). Yang et al. (5) investigated the effects of lead acetate and found that lead may induce DNA damage through a Fenton reaction by interacting proteins. Lead ion has high affinity for the sulfhydryl groups of proteins. In our study, outbred female Wistar rats were treated by gavage once per week for 10 weeks with cumulative doses of 140, 250 and 500 mg/kg body weight of lead acetate (6). Because this study is a chronic study, peripheral blood is suitable for investigation. The results were compared with negative controls. Results were statistically significant. Studies have shown that mouse peripheral blood cells are an acceptable cell population for detecting micronucleated PCEs (MNPCEs) as long as the sampling schedule accounts for the release of newly-formed micronucleated erythrocytes from bone marrow to the blood (7,8). As indicated by Hayashi (9), cells should be intact and nuclei of nucleated cells and reticulum structure of reticulocytes should fluoresce strongly green and red. In our study, we considered these identifying features and PCEs were identified by their orange–red color, mature erythrocytes by their green color and micronuclei by their yellowish color. Those differences are shown in the paper. Several studies have shown a relationship between lead levels in blood and anemia (10,11). Gurer et al. (12) indicated that lead exposure causes mild anemia along with other haematological disturbances, including considerable variability in the sizes of RBCs (anisocytosis) and irregular shapes in RBCs (poikilocytosis). These data, considered in light of the data suggesting that lead induces oxidative stress in RBCs, support the hypothesis that lead-induced oxidative stress could, in part, be responsible for the lead-induced toxicity to the haematological system (12). There is a strong interaction between the formation of micronuclei and the antioxidant system. These systems vary among living organisms. In our study, we hypothesized that exposure to lead may have the potential for micronucleus formation. In order to understand the mechanisms responsible for the micronucleus formation further cytogenetic studies are needed." @default.
• W2100163911 created "2016-06-24" @default.
• W2100163911 creator A5045101428 @default.
• W2100163911 creator A5049707126 @default.
• W2100163911 creator A5079513805 @default.
• W2100163911 date "2006-05-30" @default.
• W2100163911 modified "2023-10-18" @default.
• W2100163911 title "Re: The evaluation of micronucleus frequency by acridine orange fluorescent staining in peripheral blood of rats treated with lead acetate. (Mutagenesis, 20, 411-415, 2005)" @default.
• W2100163911 cites W1973933670 @default.
• W2100163911 cites W1987665004 @default.
• W2100163911 cites W2011279163 @default.
• W2100163911 cites W2018912133 @default.
• W2100163911 cites W2032666934 @default.
• W2100163911 cites W2060479015 @default.
• W2100163911 cites W2066494150 @default.
• W2100163911 cites W2078086041 @default.
• W2100163911 cites W2119831458 @default.
• W2100163911 cites W2136035869 @default.
• W2100163911 doi "https://doi.org/10.1093/mutage/gel027" @default.
• W2100163911 hasPublicationYear "2006" @default.
• W2100163911 type Work @default.
• W2100163911 sameAs 2100163911 @default.
• W2100163911 citedByCount "1" @default.
• W2100163911 countsByYear W21001639112020 @default.
• W2100163911 crossrefType "journal-article" @default.
• W2100163911 hasAuthorship W2100163911A5045101428 @default.
• W2100163911 hasAuthorship W2100163911A5049707126 @default.
• W2100163911 hasAuthorship W2100163911A5079513805 @default.
• W2100163911 hasConcept C104317684 @default.
• W2100163911 hasConcept C114246631 @default.
• W2100163911 hasConcept C143425029 @default.
• W2100163911 hasConcept C153911025 @default.
• W2100163911 hasConcept C178790620 @default.
• W2100163911 hasConcept C185592680 @default.
• W2100163911 hasConcept C190283241 @default.
• W2100163911 hasConcept C2776639595 @default.
• W2100163911 hasConcept C2778403015 @default.
• W2100163911 hasConcept C2778959862 @default.
• W2100163911 hasConcept C2779102032 @default.
• W2100163911 hasConcept C2779224224 @default.
• W2100163911 hasConcept C2908647359 @default.
• W2100163911 hasConcept C29730261 @default.
• W2100163911 hasConcept C33070731 @default.
• W2100163911 hasConcept C36681516 @default.
• W2100163911 hasConcept C45080847 @default.
• W2100163911 hasConcept C552990157 @default.
• W2100163911 hasConcept C55493867 @default.
• W2100163911 hasConcept C67705224 @default.
• W2100163911 hasConcept C71924100 @default.
• W2100163911 hasConcept C86803240 @default.
• W2100163911 hasConcept C98274493 @default.
• W2100163911 hasConcept C99454951 @default.
• W2100163911 hasConceptScore W2100163911C104317684 @default.
• W2100163911 hasConceptScore W2100163911C114246631 @default.
• W2100163911 hasConceptScore W2100163911C143425029 @default.
• W2100163911 hasConceptScore W2100163911C153911025 @default.
• W2100163911 hasConceptScore W2100163911C178790620 @default.
• W2100163911 hasConceptScore W2100163911C185592680 @default.
• W2100163911 hasConceptScore W2100163911C190283241 @default.
• W2100163911 hasConceptScore W2100163911C2776639595 @default.
• W2100163911 hasConceptScore W2100163911C2778403015 @default.
• W2100163911 hasConceptScore W2100163911C2778959862 @default.
• W2100163911 hasConceptScore W2100163911C2779102032 @default.
• W2100163911 hasConceptScore W2100163911C2779224224 @default.
• W2100163911 hasConceptScore W2100163911C2908647359 @default.
• W2100163911 hasConceptScore W2100163911C29730261 @default.
• W2100163911 hasConceptScore W2100163911C33070731 @default.
• W2100163911 hasConceptScore W2100163911C36681516 @default.
• W2100163911 hasConceptScore W2100163911C45080847 @default.
• W2100163911 hasConceptScore W2100163911C552990157 @default.
• W2100163911 hasConceptScore W2100163911C55493867 @default.
• W2100163911 hasConceptScore W2100163911C67705224 @default.
• W2100163911 hasConceptScore W2100163911C71924100 @default.
• W2100163911 hasConceptScore W2100163911C86803240 @default.
• W2100163911 hasConceptScore W2100163911C98274493 @default.
• W2100163911 hasConceptScore W2100163911C99454951 @default.
• W2100163911 hasLocation W21001639111 @default.
• W2100163911 hasOpenAccess W2100163911 @default.
• W2100163911 hasPrimaryLocation W21001639111 @default.
• W2100163911 hasRelatedWork W1994323227 @default.
• W2100163911 hasRelatedWork W2006804731 @default.
• W2100163911 hasRelatedWork W2011279163 @default.
• W2100163911 hasRelatedWork W2043360060 @default.
• W2100163911 hasRelatedWork W2052373946 @default.
• W2100163911 hasRelatedWork W2091894398 @default.
• W2100163911 hasRelatedWork W2136035869 @default.
• W2100163911 hasRelatedWork W2376087743 @default.
• W2100163911 hasRelatedWork W4253120065 @default.
• W2100163911 hasRelatedWork W4290115384 @default.
• W2100163911 isParatext "false" @default.
• W2100163911 isRetracted "false" @default.
• W2100163911 magId "2100163911" @default.
• W2100163911 workType "article" @default.