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• W2100173676 abstract "Abstract The hallmark of glucokinase (GCK), which catalyzes the phosphorylation of glucose during glycolysis, is its kinetic cooperativity, whose understanding at atomic detail has remained open since its discovery over 40 years ago. Herein, by using kinetic CPMG NMR spectroscopic data for 17 isoleucine side chains distributed over all parts of GCK, we show that the origin of kinetic cooperativity is rooted in intramolecular protein dynamics. Residues of glucose‐free GCK located in the small domain displayed distinct exchange behavior involving multiple conformers that are substantially populated ( p >17 %) with a k ex value of 509±51 s −1 , whereas in the glucose‐bound form these exchange processes were quenched. This exchange behavior directly competes with the enzymatic turnover rate at physiological glucose concentrations, thereby generating the sigmoidal rate dependence that defines kinetic cooperativity." @default.
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• W2100173676 date "2015-05-26" @default.
• W2100173676 modified "2023-10-18" @default.
• W2100173676 title "Kinetic Cooperativity in Human Pancreatic Glucokinase Originates from Millisecond Dynamics of the Small Domain" @default.
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• W2100173676 doi "https://doi.org/10.1002/anie.201501204" @default.
• W2100173676 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4587531" @default.
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