FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100181546> ?p ?o ?g. }

• W2100181546 endingPage "234" @default.
• W2100181546 startingPage "215" @default.
• W2100181546 abstract "Targeting apoptosis control provides a novel therapeutic approach to the treatment of cancer and other proliferative disorders. We summarize the evidence for apoptosis deregulation in cancer and describe the pivotal role of XIAP, the X‐linked Inhibitor‐of‐APoptosis. XIAP is the predominant inhibitor of caspases 3, 7 and 9 in cells, which suppresses the programmed cell death effector capability of these proteases. Evidence is presented validating XIAP as a cancer target. The inhibition or downregulation of XIAP in cancer cells lowers the apoptotic threshold, thereby inducing cell death and/or enhancing the cytotoxic action of chemotherapeutic agents. We describe the development of AEG35156 (also named GEM®640), a second generation antisense compound targeting XIAP, from concept to in vivo preclinical proof‐of‐principle studies, through formal toxicology, and to a phase 1 clinical trial in cancer patients." @default.
• W2100181546 created "2016-06-24" @default.
• W2100181546 creator A5003859308 @default.
• W2100181546 creator A5031615776 @default.
• W2100181546 creator A5032497598 @default.
• W2100181546 creator A5057601626 @default.
• W2100181546 creator A5066278436 @default.
• W2100181546 creator A5069014764 @default.
• W2100181546 creator A5088791437 @default.
• W2100181546 date "2005-11-01" @default.
• W2100181546 modified "2023-10-10" @default.
• W2100181546 title "Application of XIAP Antisense to Cancer and Other Proliferative Disorders: Development of AEG35156/ GEM®640" @default.
• W2100181546 cites W1492587973 @default.
• W2100181546 cites W1512072225 @default.
• W2100181546 cites W1515506492 @default.
• W2100181546 cites W1557686543 @default.
• W2100181546 cites W1599411566 @default.
• W2100181546 cites W1604468403 @default.
• W2100181546 cites W1618299283 @default.
• W2100181546 cites W1836699261 @default.
• W2100181546 cites W186782872 @default.
• W2100181546 cites W1920968130 @default.
• W2100181546 cites W1942297882 @default.
• W2100181546 cites W1964231591 @default.
• W2100181546 cites W1964302525 @default.
• W2100181546 cites W1966176339 @default.
• W2100181546 cites W1966798559 @default.
• W2100181546 cites W1969442168 @default.
• W2100181546 cites W1970420564 @default.
• W2100181546 cites W1970525491 @default.
• W2100181546 cites W1971125884 @default.
• W2100181546 cites W1971967721 @default.
• W2100181546 cites W1973462203 @default.
• W2100181546 cites W1974129037 @default.
• W2100181546 cites W1975449325 @default.
• W2100181546 cites W1976141746 @default.
• W2100181546 cites W1976303784 @default.
• W2100181546 cites W1976353819 @default.
• W2100181546 cites W1976457595 @default.
• W2100181546 cites W1976935037 @default.
• W2100181546 cites W1981464883 @default.
• W2100181546 cites W1983312081 @default.
• W2100181546 cites W1984789674 @default.
• W2100181546 cites W1986320887 @default.
• W2100181546 cites W1987378323 @default.
• W2100181546 cites W1990098630 @default.
• W2100181546 cites W1991865867 @default.
• W2100181546 cites W1992252639 @default.
• W2100181546 cites W1992368170 @default.
• W2100181546 cites W1992844265 @default.
• W2100181546 cites W1994489381 @default.
• W2100181546 cites W1994750525 @default.
• W2100181546 cites W1996519491 @default.
• W2100181546 cites W1997743035 @default.
• W2100181546 cites W1998956779 @default.
• W2100181546 cites W1999057673 @default.
• W2100181546 cites W2000225649 @default.
• W2100181546 cites W2001304317 @default.
• W2100181546 cites W2002645985 @default.
• W2100181546 cites W2003006566 @default.
• W2100181546 cites W2006077720 @default.
• W2100181546 cites W2006353047 @default.
• W2100181546 cites W2008355658 @default.
• W2100181546 cites W2009128649 @default.
• W2100181546 cites W2011912935 @default.
• W2100181546 cites W2013801793 @default.
• W2100181546 cites W2016548788 @default.
• W2100181546 cites W2016709307 @default.
• W2100181546 cites W2016724271 @default.
• W2100181546 cites W2018077387 @default.
• W2100181546 cites W2018116689 @default.
• W2100181546 cites W2021951737 @default.
• W2100181546 cites W2022135873 @default.
• W2100181546 cites W2022569128 @default.
• W2100181546 cites W2023118727 @default.
• W2100181546 cites W2023669728 @default.
• W2100181546 cites W2024105041 @default.
• W2100181546 cites W2025533271 @default.
• W2100181546 cites W2026036357 @default.
• W2100181546 cites W2026050954 @default.
• W2100181546 cites W2026898144 @default.
• W2100181546 cites W2027225984 @default.
• W2100181546 cites W2027610480 @default.
• W2100181546 cites W2027737461 @default.
• W2100181546 cites W2029311647 @default.
• W2100181546 cites W2030448994 @default.
• W2100181546 cites W2030805785 @default.
• W2100181546 cites W2031701445 @default.
• W2100181546 cites W2031949901 @default.
• W2100181546 cites W2032351190 @default.
• W2100181546 cites W2034269086 @default.
• W2100181546 cites W2035493275 @default.
• W2100181546 cites W2038301672 @default.
• W2100181546 cites W2039597975 @default.
• W2100181546 cites W2039601589 @default.
• W2100181546 cites W2039867956 @default.
• W2100181546 cites W2040394091 @default.
• W2100181546 cites W2041665011 @default.

• next