FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100183650> ?p ?o ?g. }

• W2100183650 endingPage "2245" @default.
• W2100183650 startingPage "2237" @default.
• W2100183650 abstract "In C57BL/6 (B6) mice, most herpes simplex virus (HSV)-specific CD8 T cells recognize a strongly immunodominant epitope on glycoprotein B (gB498) and can inhibit HSV type 1 (HSV-1) reactivation from latency in trigeminal ganglia (TG). However, half of the CD8 T cells retained in latently infected TG of B6 mice are not gB498 specific and have been largely ignored. The following observations from our current study indicate that these gB498-nonspecific CD8 T cells are HSV specific and may contribute to the control of HSV-1 latency. First, following corneal infection, OVA257-specific OT-1 CD8 T cells do not infiltrate the infected TG unless mice are simultaneously immunized with OVA257 peptide, and then they are not retained. Second, 30% of CD8 T cells in acutely infected TG that produce gamma interferon in response to HSV-1 stimulation directly ex vivo are gB498 nonspecific, and these cells maintain an activation phenotype during viral latency. Finally, gB498-nonspecific CD8 T cells are expanded in ex vivo cultures of latently infected TG and inhibit HSV-1 reactivation from latency in the absence of gB498-specific CD8 T cells. We conclude that many of the CD8 T cells that infiltrate and are retained in infected TG are HSV specific and potentially contribute to maintenance of HSV-1 latency. Identification of the viral proteins recognized by these cells will contribute to a better understanding of the dynamics of HSV-1 latency." @default.
• W2100183650 created "2016-06-24" @default.
• W2100183650 creator A5023653965 @default.
• W2100183650 creator A5036396513 @default.
• W2100183650 creator A5048676830 @default.
• W2100183650 creator A5057788524 @default.
• W2100183650 creator A5080797961 @default.
• W2100183650 date "2009-03-01" @default.
• W2100183650 modified "2023-10-16" @default.
• W2100183650 title "Reevaluating the CD8 T-Cell Response to Herpes Simplex Virus Type 1: Involvement of CD8 T Cells Reactive to Subdominant Epitopes" @default.
• W2100183650 cites W1500900725 @default.
• W2100183650 cites W1521443135 @default.
• W2100183650 cites W1921407669 @default.
• W2100183650 cites W1963816826 @default.
• W2100183650 cites W1968643495 @default.
• W2100183650 cites W1973682675 @default.
• W2100183650 cites W1985294654 @default.
• W2100183650 cites W1998844140 @default.
• W2100183650 cites W2012645004 @default.
• W2100183650 cites W2030512306 @default.
• W2100183650 cites W2032474818 @default.
• W2100183650 cites W2056330259 @default.
• W2100183650 cites W2079953431 @default.
• W2100183650 cites W2085942730 @default.
• W2100183650 cites W2086573312 @default.
• W2100183650 cites W2100024567 @default.
• W2100183650 cites W2122140614 @default.
• W2100183650 cites W2123448680 @default.
• W2100183650 cites W2125966088 @default.
• W2100183650 cites W2128264299 @default.
• W2100183650 cites W2131585285 @default.
• W2100183650 cites W2138992714 @default.
• W2100183650 cites W2156475692 @default.
• W2100183650 cites W2163357710 @default.
• W2100183650 cites W2165756490 @default.
• W2100183650 cites W2169344740 @default.
• W2100183650 doi "https://doi.org/10.1128/jvi.01699-08" @default.
• W2100183650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2643732" @default.
• W2100183650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19073721" @default.
• W2100183650 hasPublicationYear "2009" @default.
• W2100183650 type Work @default.
• W2100183650 sameAs 2100183650 @default.
• W2100183650 citedByCount "55" @default.
• W2100183650 countsByYear W21001836502012 @default.
• W2100183650 countsByYear W21001836502013 @default.
• W2100183650 countsByYear W21001836502014 @default.
• W2100183650 countsByYear W21001836502015 @default.
• W2100183650 countsByYear W21001836502016 @default.
• W2100183650 countsByYear W21001836502017 @default.
• W2100183650 countsByYear W21001836502018 @default.
• W2100183650 countsByYear W21001836502019 @default.
• W2100183650 countsByYear W21001836502020 @default.
• W2100183650 countsByYear W21001836502021 @default.
• W2100183650 countsByYear W21001836502022 @default.
• W2100183650 countsByYear W21001836502023 @default.
• W2100183650 crossrefType "journal-article" @default.
• W2100183650 hasAuthorship W2100183650A5023653965 @default.
• W2100183650 hasAuthorship W2100183650A5036396513 @default.
• W2100183650 hasAuthorship W2100183650A5048676830 @default.
• W2100183650 hasAuthorship W2100183650A5057788524 @default.
• W2100183650 hasAuthorship W2100183650A5080797961 @default.
• W2100183650 hasBestOaLocation W21001836501 @default.
• W2100183650 hasConcept C140704245 @default.
• W2100183650 hasConcept C147483822 @default.
• W2100183650 hasConcept C150903083 @default.
• W2100183650 hasConcept C153911025 @default.
• W2100183650 hasConcept C154317977 @default.
• W2100183650 hasConcept C159047783 @default.
• W2100183650 hasConcept C167672396 @default.
• W2100183650 hasConcept C195616568 @default.
• W2100183650 hasConcept C202751555 @default.
• W2100183650 hasConcept C203014093 @default.
• W2100183650 hasConcept C207001950 @default.
• W2100183650 hasConcept C2522874641 @default.
• W2100183650 hasConcept C26291073 @default.
• W2100183650 hasConcept C2776090121 @default.
• W2100183650 hasConcept C2778852064 @default.
• W2100183650 hasConcept C2781196997 @default.
• W2100183650 hasConcept C36372059 @default.
• W2100183650 hasConcept C55493867 @default.
• W2100183650 hasConcept C86803240 @default.
• W2100183650 hasConcept C8891405 @default.
• W2100183650 hasConceptScore W2100183650C140704245 @default.
• W2100183650 hasConceptScore W2100183650C147483822 @default.
• W2100183650 hasConceptScore W2100183650C150903083 @default.
• W2100183650 hasConceptScore W2100183650C153911025 @default.
• W2100183650 hasConceptScore W2100183650C154317977 @default.
• W2100183650 hasConceptScore W2100183650C159047783 @default.
• W2100183650 hasConceptScore W2100183650C167672396 @default.
• W2100183650 hasConceptScore W2100183650C195616568 @default.
• W2100183650 hasConceptScore W2100183650C202751555 @default.
• W2100183650 hasConceptScore W2100183650C203014093 @default.
• W2100183650 hasConceptScore W2100183650C207001950 @default.
• W2100183650 hasConceptScore W2100183650C2522874641 @default.
• W2100183650 hasConceptScore W2100183650C26291073 @default.
• W2100183650 hasConceptScore W2100183650C2776090121 @default.
• W2100183650 hasConceptScore W2100183650C2778852064 @default.
• W2100183650 hasConceptScore W2100183650C2781196997 @default.

• next