FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100187131> ?p ?o ?g. }

• W2100187131 endingPage "1372" @default.
• W2100187131 startingPage "1365" @default.
• W2100187131 abstract "Background: The methylenetetrahydrofolate reductase (MTHFR) genotype is associated with modification of disease and risk of neural tube defects. Plasma and red blood cell (RBC) folate and plasma homocysteine concentrations change in response to daily intakes of folic acid supplements, but no large-scale or population-based randomized trials have examined whether the MTHFR genotype modifies the observed response. Objective: We sought to determine whether the MTHFR 677C→T genotype modifies the response to folic acid supplementation during and 3 mo after discontinuation of supplementation. Design: Northern Chinese women of childbearing age were enrolled in a 6-mo supplementation trial of different folic acid doses: 100, 400, and 4000 μg/d and 4000 μg/wk. Plasma and RBC folate and plasma homocysteine concentrations were measured at baseline; after 1, 3, and 6 mo of supplementation; and 3 mo after discontinuation of supplementation. MTHFR genotyping was performed to identify a C→T mutation at position 677 (n = 932). Results: Plasma and RBC folate and homocysteine concentrations were associated with MTHFR genotype throughout the supplementation trial, regardless of folic acid dose. MTHFRTT was associated with lower folate concentrations, and the trend of TT < CC was maintained at even the highest doses. Folic acid doses of 100 μg/d or 4000 μg/wk did not reduce high homocysteine concentrations in those with the MTHFRTT genotype. Conclusion:MTHFR genotype was an independent predictor of plasma and RBC folate and plasma homocysteine concentrations and did not have a significant interaction with folic acid dose during supplementation. This trial was registered at clinicaltrials.gov as NCT00207558." @default.
• W2100187131 created "2016-06-24" @default.
• W2100187131 creator A5002016579 @default.
• W2100187131 creator A5002707076 @default.
• W2100187131 creator A5014516799 @default.
• W2100187131 creator A5042134754 @default.
• W2100187131 creator A5052714705 @default.
• W2100187131 creator A5056565515 @default.
• W2100187131 creator A5062911848 @default.
• W2100187131 creator A5071441306 @default.
• W2100187131 creator A5072268886 @default.
• W2100187131 creator A5086171363 @default.
• W2100187131 creator A5091845719 @default.
• W2100187131 date "2011-06-01" @default.
• W2100187131 modified "2023-10-06" @default.
• W2100187131 title "MTHFR 677C→T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation" @default.
• W2100187131 cites W1860283927 @default.
• W2100187131 cites W1883798927 @default.
• W2100187131 cites W1951517547 @default.
• W2100187131 cites W1999063377 @default.
• W2100187131 cites W2014817536 @default.
• W2100187131 cites W2022499727 @default.
• W2100187131 cites W2032390692 @default.
• W2100187131 cites W2036482778 @default.
• W2100187131 cites W2051136548 @default.
• W2100187131 cites W2059660018 @default.
• W2100187131 cites W2064912482 @default.
• W2100187131 cites W2070446449 @default.
• W2100187131 cites W2071856562 @default.
• W2100187131 cites W2082514717 @default.
• W2100187131 cites W2085427173 @default.
• W2100187131 cites W2087071185 @default.
• W2100187131 cites W2097547549 @default.
• W2100187131 cites W2130826341 @default.
• W2100187131 cites W2133886773 @default.
• W2100187131 cites W2138616953 @default.
• W2100187131 cites W2140622819 @default.
• W2100187131 cites W2153606794 @default.
• W2100187131 cites W2163749485 @default.
• W2100187131 cites W2165715420 @default.
• W2100187131 cites W2184088833 @default.
• W2100187131 cites W2202097761 @default.
• W2100187131 cites W2506726673 @default.
• W2100187131 cites W4206832593 @default.
• W2100187131 cites W4246413873 @default.
• W2100187131 doi "https://doi.org/10.3945/ajcn.110.004671" @default.
• W2100187131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21508090" @default.
• W2100187131 hasPublicationYear "2011" @default.
• W2100187131 type Work @default.
• W2100187131 sameAs 2100187131 @default.
• W2100187131 citedByCount "113" @default.
• W2100187131 countsByYear W21001871312012 @default.
• W2100187131 countsByYear W21001871312013 @default.
• W2100187131 countsByYear W21001871312014 @default.
• W2100187131 countsByYear W21001871312015 @default.
• W2100187131 countsByYear W21001871312016 @default.
• W2100187131 countsByYear W21001871312017 @default.
• W2100187131 countsByYear W21001871312018 @default.
• W2100187131 countsByYear W21001871312019 @default.
• W2100187131 countsByYear W21001871312020 @default.
• W2100187131 countsByYear W21001871312021 @default.
• W2100187131 countsByYear W21001871312022 @default.
• W2100187131 countsByYear W21001871312023 @default.
• W2100187131 crossrefType "journal-article" @default.
• W2100187131 hasAuthorship W2100187131A5002016579 @default.
• W2100187131 hasAuthorship W2100187131A5002707076 @default.
• W2100187131 hasAuthorship W2100187131A5014516799 @default.
• W2100187131 hasAuthorship W2100187131A5042134754 @default.
• W2100187131 hasAuthorship W2100187131A5052714705 @default.
• W2100187131 hasAuthorship W2100187131A5056565515 @default.
• W2100187131 hasAuthorship W2100187131A5062911848 @default.
• W2100187131 hasAuthorship W2100187131A5071441306 @default.
• W2100187131 hasAuthorship W2100187131A5072268886 @default.
• W2100187131 hasAuthorship W2100187131A5086171363 @default.
• W2100187131 hasAuthorship W2100187131A5091845719 @default.
• W2100187131 hasConcept C104317684 @default.
• W2100187131 hasConcept C126322002 @default.
• W2100187131 hasConcept C134018914 @default.
• W2100187131 hasConcept C135763542 @default.
• W2100187131 hasConcept C185592680 @default.
• W2100187131 hasConcept C2777090595 @default.
• W2100187131 hasConcept C2778715236 @default.
• W2100187131 hasConcept C2908647359 @default.
• W2100187131 hasConcept C43563269 @default.
• W2100187131 hasConcept C55493867 @default.
• W2100187131 hasConcept C71924100 @default.
• W2100187131 hasConcept C99454951 @default.
• W2100187131 hasConceptScore W2100187131C104317684 @default.
• W2100187131 hasConceptScore W2100187131C126322002 @default.
• W2100187131 hasConceptScore W2100187131C134018914 @default.
• W2100187131 hasConceptScore W2100187131C135763542 @default.
• W2100187131 hasConceptScore W2100187131C185592680 @default.
• W2100187131 hasConceptScore W2100187131C2777090595 @default.
• W2100187131 hasConceptScore W2100187131C2778715236 @default.
• W2100187131 hasConceptScore W2100187131C2908647359 @default.
• W2100187131 hasConceptScore W2100187131C43563269 @default.
• W2100187131 hasConceptScore W2100187131C55493867 @default.
• W2100187131 hasConceptScore W2100187131C71924100 @default.

• next