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- W2100190524 abstract "Various foods are associated with effects against metabolic diseases such as insulin resistance and type 2 diabetes; however, their mechanisms of action are mostly unclear. Fatty acids may contribute by acting as precursors of signalling molecules or by direct activity on receptors. The medium- and long-chain NEFA receptor FFA1 (free fatty acid receptor 1, previously known as GPR40) has been linked to enhancement of glucose-stimulated insulin secretion, whereas FFA4 (free fatty acid receptor 4, previously known as GPR120) has been associated with insulin-sensitising and anti-inflammatory effects, and both receptors are reported to protect pancreatic islets and promote secretion of appetite and glucose-regulating hormones. Hypothesising that FFA1 and FFA4 mediate therapeutic effects of dietary components, we screened a broad selection of NEFA on FFA1 and FFA4 and characterised active compounds in concentration-response curves. Of the screened compounds, pinolenic acid, a constituent of pine nut oil, was identified as a relatively potent and efficacious dual FFA1/FFA4 agonist, and its suitability for further studies was confirmed by additional in vitro characterisation. Pine nut oil and free and esterified pure pinolenic acid were tested in an acute glucose tolerance test in mice. Pine nut oil showed a moderately but significantly improved glucose tolerance compared with maize oil. Pure pinolenic acid or ethyl ester gave robust and highly significant improvements of glucose tolerance. In conclusion, the present results indicate that pinolenic acid is a comparatively potent and efficacious dual FFA1/FFA4 agonist that exerts antidiabetic effects in an acute mouse model. The compound thus deserves attention as a potential active dietary ingredient to prevent or counteract metabolic diseases." @default.
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- W2100190524 date "2015-04-28" @default.
- W2100190524 modified "2023-10-13" @default.
- W2100190524 title "Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases" @default.
- W2100190524 cites W1506774487 @default.
- W2100190524 cites W1599526190 @default.
- W2100190524 cites W1968405391 @default.
- W2100190524 cites W1969361515 @default.
- W2100190524 cites W1969556083 @default.
- W2100190524 cites W1969612042 @default.
- W2100190524 cites W1971450150 @default.
- W2100190524 cites W1972691065 @default.
- W2100190524 cites W1973320922 @default.
- W2100190524 cites W1973433839 @default.
- W2100190524 cites W1975917832 @default.
- W2100190524 cites W1978718896 @default.
- W2100190524 cites W1980897219 @default.
- W2100190524 cites W1982501391 @default.
- W2100190524 cites W1987520295 @default.
- W2100190524 cites W1987642121 @default.
- W2100190524 cites W1989773342 @default.
- W2100190524 cites W1991359137 @default.
- W2100190524 cites W1992955585 @default.
- W2100190524 cites W2013428424 @default.
- W2100190524 cites W2018076350 @default.
- W2100190524 cites W2019925176 @default.
- W2100190524 cites W2020275122 @default.
- W2100190524 cites W2035421462 @default.
- W2100190524 cites W2043788271 @default.
- W2100190524 cites W2044719746 @default.
- W2100190524 cites W2047116814 @default.
- W2100190524 cites W2048969251 @default.
- W2100190524 cites W2050907340 @default.
- W2100190524 cites W2053307994 @default.
- W2100190524 cites W2055291719 @default.
- W2100190524 cites W2057521072 @default.
- W2100190524 cites W2061650356 @default.
- W2100190524 cites W2066181078 @default.
- W2100190524 cites W2069247721 @default.
- W2100190524 cites W2071869156 @default.
- W2100190524 cites W2073474683 @default.
- W2100190524 cites W2076511407 @default.
- W2100190524 cites W2077936393 @default.
- W2100190524 cites W2080410583 @default.
- W2100190524 cites W2084322369 @default.
- W2100190524 cites W2084862721 @default.
- W2100190524 cites W2089163597 @default.
- W2100190524 cites W2089540591 @default.
- W2100190524 cites W2095483997 @default.
- W2100190524 cites W2096074670 @default.
- W2100190524 cites W2097503559 @default.
- W2100190524 cites W2102964449 @default.
- W2100190524 cites W2108878645 @default.
- W2100190524 cites W2109967142 @default.
- W2100190524 cites W2112379709 @default.
- W2100190524 cites W2115209757 @default.
- W2100190524 cites W2122832744 @default.
- W2100190524 cites W2128326754 @default.
- W2100190524 cites W2130404519 @default.
- W2100190524 cites W2131094572 @default.
- W2100190524 cites W2137900887 @default.
- W2100190524 cites W2140650554 @default.
- W2100190524 cites W2148919838 @default.
- W2100190524 cites W2149670889 @default.
- W2100190524 cites W2156472479 @default.
- W2100190524 cites W2159596537 @default.
- W2100190524 cites W2160181064 @default.
- W2100190524 cites W2162704444 @default.
- W2100190524 cites W2163448046 @default.
- W2100190524 cites W2413440331 @default.
- W2100190524 doi "https://doi.org/10.1017/s000711451500118x" @default.
- W2100190524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25916176" @default.
- W2100190524 hasPublicationYear "2015" @default.
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