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- W2100194806 abstract "Although some in vitro data support a direct role for C-reactive protein (CRP) in atherogenesis, there is as yet no definite evidence that CRP per se mediates atherogenesis in vivo. Whereas a recent study demonstrates that a specific binder of human CRP has cardioprotective effects in rats, studies in non-renal patients, using the Mendelian approach, suggest that CRP is not a suitable target for direct intervention. Thus, additional studies evaluating genotype (or haplotype) and vascular events are needed to clarify whether the link between elevated CRP and vascular events in numerous observational studies of chronic kidney disease (CKD) patients is causal or confounded. The availability of a specific CRP binder may be yet another tool to determine whether CRP contributes directly to atherogenesis in humans" @default.
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- W2100194806 date "2006-07-24" @default.
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- W2100194806 title "C-reactive protein—does it promote vascular disease?*" @default.
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- W2100194806 doi "https://doi.org/10.1093/ndt/gfl317" @default.
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