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- W2100202103 abstract "Overall lowering of glucose is of pivotal importance in the treatment of diabetes, with proven beneficial effects on microvascular and macrovascular outcomes. Still, patients with similar glycosylated hemoglobin levels and mean glucose values can have markedly different daily glucose excursions. The role of this glucose variability in pathophysiological pathways is the subject of debate. It is strongly related to oxidative stress in in vitro, animal, and human studies in an experimental setting. However, in real-life human studies including type 1 and type 2 diabetes patients, there is neither a reproducible relation with oxidative stress nor a correlation between short-term glucose variability and retinopathy, nephropathy, or neuropathy. On the other hand, there is some evidence that long-term glycemic variability might be related to microvascular complications in type 1 and type 2 diabetes. Regarding mortality, a convincing relationship with short-term glucose variability has only been demonstrated in nondiabetic, critically ill patients. Also, glucose variability may have a role in the prediction of severe hypoglycemia. In this review, we first provide an overview of the various methods to measure glucose variability. Second, we review current literature regarding glucose variability and its relation to oxidative stress, long-term diabetic complications, and hypoglycemia. Finally, we make recommendations on whether and how to target glucose variability, concluding that at present we lack both the compelling evidence and the means to target glucose variability separately from all efforts to lower mean glucose while avoiding hypoglycemia." @default.
- W2100202103 created "2016-06-24" @default.
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- W2100202103 date "2010-04-01" @default.
- W2100202103 modified "2023-10-16" @default.
- W2100202103 title "Glucose Variability; Does It Matter?" @default.
- W2100202103 cites W145990486 @default.
- W2100202103 cites W1965776430 @default.
- W2100202103 cites W1967265218 @default.
- W2100202103 cites W1972457434 @default.
- W2100202103 cites W1973419629 @default.
- W2100202103 cites W1974908539 @default.
- W2100202103 cites W1976589802 @default.
- W2100202103 cites W1979302709 @default.
- W2100202103 cites W1980717583 @default.
- W2100202103 cites W1981121993 @default.
- W2100202103 cites W1983929919 @default.
- W2100202103 cites W1985651276 @default.
- W2100202103 cites W1987610957 @default.
- W2100202103 cites W1992103610 @default.
- W2100202103 cites W1992458693 @default.
- W2100202103 cites W1994471498 @default.
- W2100202103 cites W1994682895 @default.
- W2100202103 cites W1998028432 @default.
- W2100202103 cites W2006783386 @default.
- W2100202103 cites W2012627116 @default.
- W2100202103 cites W2021831716 @default.
- W2100202103 cites W2026085195 @default.
- W2100202103 cites W2029699674 @default.
- W2100202103 cites W2030258854 @default.
- W2100202103 cites W2031916024 @default.
- W2100202103 cites W2037449342 @default.
- W2100202103 cites W2039958848 @default.
- W2100202103 cites W2040961193 @default.
- W2100202103 cites W2042045847 @default.
- W2100202103 cites W2044437167 @default.
- W2100202103 cites W2044943066 @default.
- W2100202103 cites W2063016600 @default.
- W2100202103 cites W2063315257 @default.
- W2100202103 cites W2069045786 @default.
- W2100202103 cites W2072219150 @default.
- W2100202103 cites W2075443305 @default.
- W2100202103 cites W2075714988 @default.
- W2100202103 cites W2078936505 @default.
- W2100202103 cites W2080465897 @default.
- W2100202103 cites W2085906294 @default.
- W2100202103 cites W2087220735 @default.
- W2100202103 cites W2087976889 @default.
- W2100202103 cites W2089982820 @default.
- W2100202103 cites W2098036900 @default.
- W2100202103 cites W2101741459 @default.
- W2100202103 cites W2104011587 @default.
- W2100202103 cites W2105677350 @default.
- W2100202103 cites W2115285670 @default.
- W2100202103 cites W2126781806 @default.
- W2100202103 cites W2131878262 @default.
- W2100202103 cites W2135103902 @default.
- W2100202103 cites W2138185343 @default.
- W2100202103 cites W2142433177 @default.
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- W2100202103 cites W2145562665 @default.
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- W2100202103 cites W2149194615 @default.
- W2100202103 cites W2152591579 @default.
- W2100202103 cites W2153510001 @default.
- W2100202103 cites W2154050923 @default.
- W2100202103 cites W2155931459 @default.
- W2100202103 cites W2156577941 @default.
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- W2100202103 cites W2296048013 @default.
- W2100202103 cites W2471605942 @default.
- W2100202103 cites W2769264260 @default.
- W2100202103 cites W3211353401 @default.
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- W2100202103 cites W4248932937 @default.
- W2100202103 cites W4252271922 @default.
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- W2100202103 doi "https://doi.org/10.1210/er.2009-0021" @default.
- W2100202103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19966012" @default.
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