FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100212868> ?p ?o ?g. }

• W2100212868 endingPage "H2212" @default.
• W2100212868 startingPage "H2204" @default.
• W2100212868 abstract "Mitogen-activated protein kinases (MAPKs) play different regulatory roles in signaling oxidative stress-induced apoptosis in cardiac ventricular myocytes. The regulation and functional role of cross-talk between p38 MAPK and extracellular signal-regulated kinase (ERK) pathways were investigated in cardiac ventricular myocytes in the present study. We demonstrated that inhibition of p38 MAPK with SB-203580 and SB-239063 enhanced H(2)O(2)-stimulated ERK phosphorylation, whereas preactivation of p38 MAPK with sodium arsenite reduced H(2)O(2)-stimulated ERK phosphorylation. In addition, pretreatment of cells with the protein phosphatase 2A (PP2A) inhibitors okadaic acid and fostriecin increased basal and H(2)O(2)-stimulated ERK phosphorylation. We also found that PP2A coimmunoprecipitated with ERK and MAPK/ERK (MEK) in cardiac ventricular myocytes, and H(2)O(2) increased the ERK-associated PP2A activity that was blocked by inhibition of p38 MAPK. Finally, H(2)O(2)-induced apoptosis was attenuated by p38 MAPK or PP2A inhibition, whereas it was enhanced by MEK inhibition. Thus the present study demonstrated that p38 MAPK activation decreases H(2)O(2)-induced ERK activation through a PP2A-dependent mechanism in cardiac ventricular myocytes. This represents a novel cellular mechanism that allows for interaction of two opposing MAPK pathways and fine modulation of apoptosis during oxidative stress." @default.
• W2100212868 created "2016-06-24" @default.
• W2100212868 creator A5042016412 @default.
• W2100212868 creator A5072128329 @default.
• W2100212868 date "2004-06-01" @default.
• W2100212868 modified "2023-10-05" @default.
• W2100212868 title "Protein phosphatase 2A-mediated cross-talk between p38 MAPK and ERK in apoptosis of cardiac myocytes" @default.
• W2100212868 cites W1512809531 @default.
• W2100212868 cites W1967780354 @default.
• W2100212868 cites W1972857272 @default.
• W2100212868 cites W1976385326 @default.
• W2100212868 cites W1977062537 @default.
• W2100212868 cites W1985264276 @default.
• W2100212868 cites W1987790381 @default.
• W2100212868 cites W1995296724 @default.
• W2100212868 cites W1997218197 @default.
• W2100212868 cites W2001333805 @default.
• W2100212868 cites W2003256325 @default.
• W2100212868 cites W2016610889 @default.
• W2100212868 cites W2017968555 @default.
• W2100212868 cites W2020184457 @default.
• W2100212868 cites W2031557719 @default.
• W2100212868 cites W2038638713 @default.
• W2100212868 cites W2044481116 @default.
• W2100212868 cites W2049370164 @default.
• W2100212868 cites W2053286013 @default.
• W2100212868 cites W2056671431 @default.
• W2100212868 cites W2062567347 @default.
• W2100212868 cites W2063522301 @default.
• W2100212868 cites W2065907781 @default.
• W2100212868 cites W2068502127 @default.
• W2100212868 cites W2076945543 @default.
• W2100212868 cites W2078006089 @default.
• W2100212868 cites W2088764696 @default.
• W2100212868 cites W2091061305 @default.
• W2100212868 cites W2106263242 @default.
• W2100212868 cites W2107944043 @default.
• W2100212868 cites W2111038541 @default.
• W2100212868 cites W2114235073 @default.
• W2100212868 cites W2115403241 @default.
• W2100212868 cites W2127694515 @default.
• W2100212868 cites W2130027917 @default.
• W2100212868 cites W2134099309 @default.
• W2100212868 cites W2136024858 @default.
• W2100212868 cites W2139244522 @default.
• W2100212868 cites W2155591792 @default.
• W2100212868 cites W2158212151 @default.
• W2100212868 cites W2161686109 @default.
• W2100212868 cites W4240253200 @default.
• W2100212868 doi "https://doi.org/10.1152/ajpheart.01050.2003" @default.
• W2100212868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14962831" @default.
• W2100212868 hasPublicationYear "2004" @default.
• W2100212868 type Work @default.
• W2100212868 sameAs 2100212868 @default.
• W2100212868 citedByCount "141" @default.
• W2100212868 countsByYear W21002128682012 @default.
• W2100212868 countsByYear W21002128682013 @default.
• W2100212868 countsByYear W21002128682014 @default.
• W2100212868 countsByYear W21002128682015 @default.
• W2100212868 countsByYear W21002128682016 @default.
• W2100212868 countsByYear W21002128682017 @default.
• W2100212868 countsByYear W21002128682018 @default.
• W2100212868 countsByYear W21002128682019 @default.
• W2100212868 countsByYear W21002128682020 @default.
• W2100212868 countsByYear W21002128682021 @default.
• W2100212868 countsByYear W21002128682022 @default.
• W2100212868 countsByYear W21002128682023 @default.
• W2100212868 crossrefType "journal-article" @default.
• W2100212868 hasAuthorship W2100212868A5042016412 @default.
• W2100212868 hasAuthorship W2100212868A5072128329 @default.
• W2100212868 hasConcept C11960822 @default.
• W2100212868 hasConcept C178666793 @default.
• W2100212868 hasConcept C184235292 @default.
• W2100212868 hasConcept C185592680 @default.
• W2100212868 hasConcept C207200792 @default.
• W2100212868 hasConcept C2776953658 @default.
• W2100212868 hasConcept C389152 @default.
• W2100212868 hasConcept C51551487 @default.
• W2100212868 hasConcept C57074206 @default.
• W2100212868 hasConcept C86803240 @default.
• W2100212868 hasConcept C95444343 @default.
• W2100212868 hasConcept C97029542 @default.
• W2100212868 hasConceptScore W2100212868C11960822 @default.
• W2100212868 hasConceptScore W2100212868C178666793 @default.
• W2100212868 hasConceptScore W2100212868C184235292 @default.
• W2100212868 hasConceptScore W2100212868C185592680 @default.
• W2100212868 hasConceptScore W2100212868C207200792 @default.
• W2100212868 hasConceptScore W2100212868C2776953658 @default.
• W2100212868 hasConceptScore W2100212868C389152 @default.
• W2100212868 hasConceptScore W2100212868C51551487 @default.
• W2100212868 hasConceptScore W2100212868C57074206 @default.
• W2100212868 hasConceptScore W2100212868C86803240 @default.
• W2100212868 hasConceptScore W2100212868C95444343 @default.
• W2100212868 hasConceptScore W2100212868C97029542 @default.
• W2100212868 hasIssue "6" @default.
• W2100212868 hasLocation W21002128681 @default.
• W2100212868 hasLocation W21002128682 @default.
• W2100212868 hasOpenAccess W2100212868 @default.

• next