FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100216755> ?p ?o ?g. }

• W2100216755 endingPage "235" @default.
• W2100216755 startingPage "223" @default.
• W2100216755 abstract "Abstract The prevailing view of sexual differentiation of mammalian brain is that androgen synthesized in the fetal and neonatal testis and aromatized centrally during a perinatal sensitive period is the sole source of brain estradiol and the primary determinant of sex differences. Subregions of the diencephalon are among the most sexually dimorphic in the brain, and there are well-established sex differences in the amount of testosterone and estradiol measured in the hypothalamus and preoptic area during the perinatal period. We previously reported unexpectedly high estradiol in the hippocampus and cortex of both male and female newborn rat. This prompted a thorough investigation of the developmental profile of steroids in the rat brain using RIA to quantify the level of estradiol, testosterone, and dihydrotestosterone in discrete subregions of the brain from embryonic d 19 to adulthood. Plasma estradiol levels from individual animals were assessed when sufficient sample was available. A significant sex difference in hypothalamic testosterone prior to birth was consistent with previous findings. Postnatally, there was a distinct pattern of changing steroid concentrations in each brain region, and these were unrelated to circulating steroid. Removal of the gonads and adrenals at birth did not significantly reduce steroids in any brain region assayed 3 d later. Aromatase activity was detectable in all brain areas at birth, and the difference in activity level paralleled the observed regional differences in estradiol content. Based on these findings, we propose that steroidogenesis in the brain, independent of peripherally derived precursors, may play a critical role in mammalian brain development of both sexes, beyond the establishment of sex differences." @default.
• W2100216755 created "2016-06-24" @default.
• W2100216755 creator A5031501731 @default.
• W2100216755 creator A5053891374 @default.
• W2100216755 date "2011-01-01" @default.
• W2100216755 modified "2023-10-16" @default.
• W2100216755 title "Developmental Time Course of Estradiol, Testosterone, and Dihydrotestosterone Levels in Discrete Regions of Male and Female Rat Brain" @default.
• W2100216755 cites W1509817160 @default.
• W2100216755 cites W1513652543 @default.
• W2100216755 cites W1969474756 @default.
• W2100216755 cites W1981106530 @default.
• W2100216755 cites W1981135650 @default.
• W2100216755 cites W1985029845 @default.
• W2100216755 cites W1985899364 @default.
• W2100216755 cites W1986891802 @default.
• W2100216755 cites W1988187565 @default.
• W2100216755 cites W1996011857 @default.
• W2100216755 cites W2000448196 @default.
• W2100216755 cites W2001302689 @default.
• W2100216755 cites W2005006458 @default.
• W2100216755 cites W2005704396 @default.
• W2100216755 cites W2006420315 @default.
• W2100216755 cites W2011700227 @default.
• W2100216755 cites W2013413404 @default.
• W2100216755 cites W2016343046 @default.
• W2100216755 cites W2016890075 @default.
• W2100216755 cites W2017936386 @default.
• W2100216755 cites W2038042500 @default.
• W2100216755 cites W2042033404 @default.
• W2100216755 cites W2042571403 @default.
• W2100216755 cites W2042871946 @default.
• W2100216755 cites W2043159419 @default.
• W2100216755 cites W2048202584 @default.
• W2100216755 cites W2050975536 @default.
• W2100216755 cites W2059494413 @default.
• W2100216755 cites W2077420563 @default.
• W2100216755 cites W2089262029 @default.
• W2100216755 cites W2089453609 @default.
• W2100216755 cites W2089955310 @default.
• W2100216755 cites W2092103006 @default.
• W2100216755 cites W2094406965 @default.
• W2100216755 cites W2096178975 @default.
• W2100216755 cites W2096407616 @default.
• W2100216755 cites W2136251430 @default.
• W2100216755 cites W2137799518 @default.
• W2100216755 cites W2140317360 @default.
• W2100216755 cites W2144727302 @default.
• W2100216755 cites W2149142116 @default.
• W2100216755 cites W2151913401 @default.
• W2100216755 cites W2162109306 @default.
• W2100216755 cites W2165820694 @default.
• W2100216755 cites W4253693469 @default.
• W2100216755 doi "https://doi.org/10.1210/en.2010-0607" @default.
• W2100216755 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3033055" @default.
• W2100216755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21068160" @default.
• W2100216755 hasPublicationYear "2011" @default.
• W2100216755 type Work @default.
• W2100216755 sameAs 2100216755 @default.
• W2100216755 citedByCount "244" @default.
• W2100216755 countsByYear W21002167552012 @default.
• W2100216755 countsByYear W21002167552013 @default.
• W2100216755 countsByYear W21002167552014 @default.
• W2100216755 countsByYear W21002167552015 @default.
• W2100216755 countsByYear W21002167552016 @default.
• W2100216755 countsByYear W21002167552017 @default.
• W2100216755 countsByYear W21002167552018 @default.
• W2100216755 countsByYear W21002167552019 @default.
• W2100216755 countsByYear W21002167552020 @default.
• W2100216755 countsByYear W21002167552021 @default.
• W2100216755 countsByYear W21002167552022 @default.
• W2100216755 countsByYear W21002167552023 @default.
• W2100216755 crossrefType "journal-article" @default.
• W2100216755 hasAuthorship W2100216755A5031501731 @default.
• W2100216755 hasAuthorship W2100216755A5053891374 @default.
• W2100216755 hasBestOaLocation W21002167551 @default.
• W2100216755 hasConcept C104317684 @default.
• W2100216755 hasConcept C105083479 @default.
• W2100216755 hasConcept C121608353 @default.
• W2100216755 hasConcept C126322002 @default.
• W2100216755 hasConcept C134018914 @default.
• W2100216755 hasConcept C146819174 @default.
• W2100216755 hasConcept C2775969318 @default.
• W2100216755 hasConcept C2776166826 @default.
• W2100216755 hasConcept C2777003273 @default.
• W2100216755 hasConcept C2777164284 @default.
• W2100216755 hasConcept C2777911890 @default.
• W2100216755 hasConcept C2778575703 @default.
• W2100216755 hasConcept C2779279991 @default.
• W2100216755 hasConcept C2779881493 @default.
• W2100216755 hasConcept C2779938979 @default.
• W2100216755 hasConcept C2780902042 @default.
• W2100216755 hasConcept C2781161787 @default.
• W2100216755 hasConcept C530470458 @default.
• W2100216755 hasConcept C55493867 @default.
• W2100216755 hasConcept C63405245 @default.
• W2100216755 hasConcept C71315377 @default.
• W2100216755 hasConcept C71924100 @default.
• W2100216755 hasConcept C86803240 @default.

• next