FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100225900> ?p ?o ?g. }

• W2100225900 abstract "In childhood onset GH deficiency (GHD) a reduction in left ventricular mass (LV-mass) and impairment of systolic function as well an impairment in glomerular filtration rate (GFR) has been shown. The aim of the present study was to assess if a low GH dose resulted in an improvement in morphological and functional parameters of these organs.Eleven patients with childhood onset GHD were investigated before and after 10 months of GH treatment at a dose of 1.5 IU/day (range 1-2), corresponding to 0.02 IU/kg/day or 7 microg/ kg/day. The GH dose resulted in a serum IGF-I level in the normal range in all but one patient.Doppler echocardiography of the heart and ultrasound examination of the kidneys was performed. Glomerular filtration rate (GFR) was estimated with iohexol clearance and urinary proteinuria was measured with 24-h urinary samples collected for analyses of albumin, alpha-1-microglobulin, IgG and albumin/creatinine clearance ratio. Body composition was measured by bioelectric impedance analysis.L V-mass index increased significantly after GH treatment (P = 0.04), and there was a clear trend for a positive correlation between the increase in serum IGF-I and the increase in LV-mass index, although it did not reach significance (r= 0.57, P = 0.07). GH treatment did not increase cardiac fractional shortening. Kidney length increased significantly (P = 0.02) with an average increase of 1 cm (range - 0.5-1.5 cm). No significant changes in median GFR or serum creatinine were recorded. Three patients with subnormal GFR before GH treatment normalized after 10 months of treatment. Urine analysis showed no abnormalities before or after GH treatment. A significant decrease in percentage fat mass was recorded (P = 0.03).A low individualized GH dose to adults with childhood onset GHD resulted in an increase in LV-mass index and kidney length. Re-establishing GH treatment with a low dose in this patient group can lead to a further somatic maturation of these organs, probably not accomplished previously." @default.
• W2100225900 created "2016-06-24" @default.
• W2100225900 creator A5034432189 @default.
• W2100225900 creator A5043317066 @default.
• W2100225900 creator A5067360751 @default.
• W2100225900 creator A5072811560 @default.
• W2100225900 creator A5077667243 @default.
• W2100225900 creator A5082342662 @default.
• W2100225900 date "2001-12-01" @default.
• W2100225900 modified "2023-09-24" @default.
• W2100225900 title "Low individualized growth hormone (GH) dose increased renal and cardiac growth in young adults with childhood onset GH deficiency" @default.
• W2100225900 cites W1599952788 @default.
• W2100225900 cites W1967996197 @default.
• W2100225900 cites W1968644668 @default.
• W2100225900 cites W1978115151 @default.
• W2100225900 cites W1987578547 @default.
• W2100225900 cites W1995934832 @default.
• W2100225900 cites W1997505612 @default.
• W2100225900 cites W2011309533 @default.
• W2100225900 cites W2020108509 @default.
• W2100225900 cites W2030298074 @default.
• W2100225900 cites W2036800476 @default.
• W2100225900 cites W2043750439 @default.
• W2100225900 cites W2044022390 @default.
• W2100225900 cites W2051076996 @default.
• W2100225900 cites W2064332189 @default.
• W2100225900 cites W2066365517 @default.
• W2100225900 cites W2080188191 @default.
• W2100225900 cites W2082524369 @default.
• W2100225900 cites W2086956756 @default.
• W2100225900 cites W2088136147 @default.
• W2100225900 cites W2095611917 @default.
• W2100225900 cites W2138494404 @default.
• W2100225900 cites W2161622680 @default.
• W2100225900 cites W2283537712 @default.
• W2100225900 doi "https://doi.org/10.1046/j.1365-2265.2001.01413.x" @default.
• W2100225900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11895215" @default.
• W2100225900 hasPublicationYear "2001" @default.
• W2100225900 type Work @default.
• W2100225900 sameAs 2100225900 @default.
• W2100225900 citedByCount "16" @default.
• W2100225900 countsByYear W21002259002013 @default.
• W2100225900 countsByYear W21002259002017 @default.
• W2100225900 countsByYear W21002259002019 @default.
• W2100225900 countsByYear W21002259002021 @default.
• W2100225900 crossrefType "journal-article" @default.
• W2100225900 hasAuthorship W2100225900A5034432189 @default.
• W2100225900 hasAuthorship W2100225900A5043317066 @default.
• W2100225900 hasAuthorship W2100225900A5067360751 @default.
• W2100225900 hasAuthorship W2100225900A5072811560 @default.
• W2100225900 hasAuthorship W2100225900A5077667243 @default.
• W2100225900 hasAuthorship W2100225900A5082342662 @default.
• W2100225900 hasConcept C126322002 @default.
• W2100225900 hasConcept C134018914 @default.
• W2100225900 hasConcept C159641895 @default.
• W2100225900 hasConcept C2780221984 @default.
• W2100225900 hasConcept C2780306776 @default.
• W2100225900 hasConcept C71924100 @default.
• W2100225900 hasConcept C77411442 @default.
• W2100225900 hasConceptScore W2100225900C126322002 @default.
• W2100225900 hasConceptScore W2100225900C134018914 @default.
• W2100225900 hasConceptScore W2100225900C159641895 @default.
• W2100225900 hasConceptScore W2100225900C2780221984 @default.
• W2100225900 hasConceptScore W2100225900C2780306776 @default.
• W2100225900 hasConceptScore W2100225900C71924100 @default.
• W2100225900 hasConceptScore W2100225900C77411442 @default.
• W2100225900 hasLocation W21002259001 @default.
• W2100225900 hasLocation W21002259002 @default.
• W2100225900 hasOpenAccess W2100225900 @default.
• W2100225900 hasPrimaryLocation W21002259001 @default.
• W2100225900 hasRelatedWork W1968644668 @default.
• W2100225900 hasRelatedWork W1982675679 @default.
• W2100225900 hasRelatedWork W1990259931 @default.
• W2100225900 hasRelatedWork W1998181416 @default.
• W2100225900 hasRelatedWork W2002675447 @default.
• W2100225900 hasRelatedWork W2032673083 @default.
• W2100225900 hasRelatedWork W2036800476 @default.
• W2100225900 hasRelatedWork W2044123906 @default.
• W2100225900 hasRelatedWork W2045428698 @default.
• W2100225900 hasRelatedWork W2054229227 @default.
• W2100225900 hasRelatedWork W2070865932 @default.
• W2100225900 hasRelatedWork W2084373485 @default.
• W2100225900 hasRelatedWork W2086956756 @default.
• W2100225900 hasRelatedWork W2093900930 @default.
• W2100225900 hasRelatedWork W2116795137 @default.
• W2100225900 hasRelatedWork W2120108803 @default.
• W2100225900 hasRelatedWork W2132001222 @default.
• W2100225900 hasRelatedWork W2161622680 @default.
• W2100225900 hasRelatedWork W2296419927 @default.
• W2100225900 hasRelatedWork W2992627072 @default.
• W2100225900 isParatext "false" @default.
• W2100225900 isRetracted "false" @default.
• W2100225900 magId "2100225900" @default.
• W2100225900 workType "article" @default.