FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100235352> ?p ?o ?g. }

• W2100235352 endingPage "44" @default.
• W2100235352 startingPage "36" @default.
• W2100235352 abstract "Both reactive oxygen species (ROS) and insulin resistance have been reported to play essential pathophysiological roles in cardiovascular diseases, such as hypertension and atherosclerosis. However, the mechanistic link between ROS and insulin resistance in the vasculature remains unclear. Recently we have shown that insulin causes membrane hyperpolarization via ATP-sensitive potassium (KATP) channel activation, which is mediated by phosphatidylinositol 3-kinase (PI3-K) in cultured vascular smooth muscle cells (VSMCs). KATP channel in the vasculature is critical in the regulation of vascular tonus. Here we examined the effects of ROS induced by hydrogen peroxide (H2O2) on insulin-induced KATP channel activities in cultured VSMCs, A10 cells. H2O2 (10 µM) increased significantly intercellular ROS in A10 cells. By using a cell-attached patch clamp experiment, 10 µM H2O2 suppressed significantly insulin-induced KATP channel activation without inhibition of insulin receptor signal transduction component including IRS and Akt in A10 cells. Furthermore 10 µM H2O2 suppressed significantly pinacidil-induced KATP channel activation in A10 cells. These data suggest that H2O2 might inhibit directly KATP channel independent of insulin signaling pathway. This study may contribute to our understanding of mechanisms of insulin resistance-associated cardiovascular disease. J. Med. Invest. 59: 36-44, February, 2012" @default.
• W2100235352 created "2016-06-24" @default.
• W2100235352 creator A5008767253 @default.
• W2100235352 creator A5020382541 @default.
• W2100235352 creator A5038923350 @default.
• W2100235352 creator A5039446098 @default.
• W2100235352 creator A5051220937 @default.
• W2100235352 creator A5063877391 @default.
• W2100235352 creator A5077865818 @default.
• W2100235352 creator A5091757845 @default.
• W2100235352 date "2012-01-01" @default.
• W2100235352 modified "2023-09-25" @default.
• W2100235352 title "Hydrogen peroxide inhibits insulin-induced ATP-sensitive potassium channel activation independent of insulin signaling pathway in cultured vascular smooth muscle cells" @default.
• W2100235352 cites W1541422600 @default.
• W2100235352 cites W1651282701 @default.
• W2100235352 cites W1757645550 @default.
• W2100235352 cites W1866620858 @default.
• W2100235352 cites W1901856024 @default.
• W2100235352 cites W1972400285 @default.
• W2100235352 cites W1973745063 @default.
• W2100235352 cites W1980007713 @default.
• W2100235352 cites W1981535533 @default.
• W2100235352 cites W1987700050 @default.
• W2100235352 cites W1990501950 @default.
• W2100235352 cites W2004711866 @default.
• W2100235352 cites W2007018003 @default.
• W2100235352 cites W2009667219 @default.
• W2100235352 cites W2011696305 @default.
• W2100235352 cites W2030585484 @default.
• W2100235352 cites W2032609739 @default.
• W2100235352 cites W2036451354 @default.
• W2100235352 cites W2043155515 @default.
• W2100235352 cites W2048569323 @default.
• W2100235352 cites W2052391501 @default.
• W2100235352 cites W2056564646 @default.
• W2100235352 cites W2076186944 @default.
• W2100235352 cites W2077467622 @default.
• W2100235352 cites W2077528102 @default.
• W2100235352 cites W2080938154 @default.
• W2100235352 cites W2081748503 @default.
• W2100235352 cites W2083990676 @default.
• W2100235352 cites W2088723641 @default.
• W2100235352 cites W2101826414 @default.
• W2100235352 cites W2111154780 @default.
• W2100235352 cites W2142567521 @default.
• W2100235352 cites W2152656461 @default.
• W2100235352 cites W2153475498 @default.
• W2100235352 cites W2154529549 @default.
• W2100235352 cites W2471605942 @default.
• W2100235352 cites W4245934347 @default.
• W2100235352 doi "https://doi.org/10.2152/jmi.59.36" @default.
• W2100235352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22449991" @default.
• W2100235352 hasPublicationYear "2012" @default.
• W2100235352 type Work @default.
• W2100235352 sameAs 2100235352 @default.
• W2100235352 citedByCount "13" @default.
• W2100235352 countsByYear W21002353522015 @default.
• W2100235352 countsByYear W21002353522016 @default.
• W2100235352 countsByYear W21002353522017 @default.
• W2100235352 countsByYear W21002353522018 @default.
• W2100235352 countsByYear W21002353522019 @default.
• W2100235352 countsByYear W21002353522020 @default.
• W2100235352 countsByYear W21002353522021 @default.
• W2100235352 countsByYear W21002353522022 @default.
• W2100235352 crossrefType "journal-article" @default.
• W2100235352 hasAuthorship W2100235352A5008767253 @default.
• W2100235352 hasAuthorship W2100235352A5020382541 @default.
• W2100235352 hasAuthorship W2100235352A5038923350 @default.
• W2100235352 hasAuthorship W2100235352A5039446098 @default.
• W2100235352 hasAuthorship W2100235352A5051220937 @default.
• W2100235352 hasAuthorship W2100235352A5063877391 @default.
• W2100235352 hasAuthorship W2100235352A5077865818 @default.
• W2100235352 hasAuthorship W2100235352A5091757845 @default.
• W2100235352 hasBestOaLocation W21002353521 @default.
• W2100235352 hasConcept C102942909 @default.
• W2100235352 hasConcept C112446052 @default.
• W2100235352 hasConcept C126322002 @default.
• W2100235352 hasConcept C134018914 @default.
• W2100235352 hasConcept C185592680 @default.
• W2100235352 hasConcept C2775984225 @default.
• W2100235352 hasConcept C2776309818 @default.
• W2100235352 hasConcept C2777391703 @default.
• W2100235352 hasConcept C2779306644 @default.
• W2100235352 hasConcept C2779395532 @default.
• W2100235352 hasConcept C2779768347 @default.
• W2100235352 hasConcept C2992686903 @default.
• W2100235352 hasConcept C48349386 @default.
• W2100235352 hasConcept C555293320 @default.
• W2100235352 hasConcept C62478195 @default.
• W2100235352 hasConcept C71924100 @default.
• W2100235352 hasConcept C75217442 @default.
• W2100235352 hasConcept C83743174 @default.
• W2100235352 hasConcept C86803240 @default.
• W2100235352 hasConcept C95444343 @default.
• W2100235352 hasConceptScore W2100235352C102942909 @default.
• W2100235352 hasConceptScore W2100235352C112446052 @default.
• W2100235352 hasConceptScore W2100235352C126322002 @default.
• W2100235352 hasConceptScore W2100235352C134018914 @default.

• next