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- W2100237319 endingPage "4805" @default.
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- W2100237319 abstract "Despite recent advances in our understanding of the biological basis of prostate cancer, the management of the disease, especially in the castration-resistant phase, remains a significant challenge. Deregulation of the phosphatidylinositol 3-kinase pathway is increasingly implicated in prostate carcinogenesis. In this review, we detail the role of this pathway in the pathogenesis of prostate cancer and the rapidly evolving therapeutic implications of targeting it. In particular, we highlight the importance of the appropriate selection of agents and combinations, and the critical role of predictive and pharmocodynamic biomarkers." @default.
- W2100237319 created "2016-06-24" @default.
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- W2100237319 date "2009-07-29" @default.
- W2100237319 modified "2023-10-14" @default.
- W2100237319 title "Targeting the PI3K/AKT Pathway for the Treatment of Prostate Cancer" @default.
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- W2100237319 doi "https://doi.org/10.1158/1078-0432.ccr-08-0125" @default.
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