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• W2100239569 abstract "4-Methoxycinnamaldehyde, an active constituent of Agastache rugosa, was examined for its cytoprotective activity against RSV by XTT method in human larynx carcinoma cell line. 4-Methoxycinnamaldehyde could effectively inhibit cytopathic effect of RSV (p<0.0001) with an estimated IC(50) of 0.055microg/ml and a selectivity index (SI) of 898.2. 4-Methoxycinnamaldehyde (0.03microg/ml) could inhibit viral entrance by interfering viral attachment (IC(50) of 0.06microg/ml; p<0.0001) and internalization (IC(50) of 0.01microg/ml; p<0.0001). 4-Methoxycinnamaldehyde significantly increased the basal production of IFN (p=0.0015), but not the virus-induced IFN production. Therefore, its cytoprotective activity against RSV was not mediated by interferon. In conclusion, 4-methoxycinnamaldehyde might be helpful to manage the disease induced by RSV infection." @default.
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• W2100239569 date "2009-09-01" @default.
• W2100239569 modified "2023-10-14" @default.
• W2100239569 title "4-Methoxycinnamaldehyde inhibited human respiratory syncytial virus in a human larynx carcinoma cell line" @default.
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• W2100239569 doi "https://doi.org/10.1016/j.phymed.2009.02.016" @default.
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