Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100244098> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2100244098 endingPage "65" @default.
- W2100244098 startingPage "61" @default.
- W2100244098 abstract "Although there have been many studies on this topic, the molecular mechanism of the toxic effects of hyperammonemia on cells has not yet been fully explained. Recent studies have held oxidative stress mechanisms responsible for hyperammonemia-induced cell damage. Kidney functions are affected in diseases associated with an increase in ammonia in the blood. Our study tries to determine whether oxidative stress mechanisms are responsible for kidney damage in chronic hyperammonemia. We also investigated whether kidney damage is dependent on possible reactive oxygen products associated with the xanthine oxidase (XO) enzyme and whether the possible association can be inhibited with allopurinol, an XO enzyme inhibitor. The study took into consideration the enzyme activities of XO, xanthine dehydrogenase (XDH), superoxide dismutase (SOD), glutathione-S-transferase (GST), as well as protein thiol (P-SH) and malondialdehyde (MDA) levels. The data found demonstrated that chronic hyperammonemia had oxidative stress effects on the kidney, and that kidney XO and XDH activity changed. However, it was not possible to inhibit this oxidative stress in the kidney using allopurinol. Thus, we could not conclude that oxidative stress is an XO-dependent mechanism. The outcomes of the study suggested that this oxidative situation arising in hyperammonemia occurred through a mechanism other than the XO enzyme." @default.
- W2100244098 created "2016-06-24" @default.
- W2100244098 creator A5031069675 @default.
- W2100244098 creator A5031287265 @default.
- W2100244098 creator A5045435513 @default.
- W2100244098 date "2011-01-10" @default.
- W2100244098 modified "2023-09-26" @default.
- W2100244098 title "Investigation of the Oxidative Effect of Chronic Hyperammonemia on the Kidney and the Possible Protective Effect of Allopurinol" @default.
- W2100244098 cites W1759706356 @default.
- W2100244098 cites W1953423403 @default.
- W2100244098 cites W1963489509 @default.
- W2100244098 cites W1968004265 @default.
- W2100244098 cites W1978838570 @default.
- W2100244098 cites W1980819126 @default.
- W2100244098 cites W1999810369 @default.
- W2100244098 cites W2000767238 @default.
- W2100244098 cites W2006141130 @default.
- W2100244098 cites W2009109749 @default.
- W2100244098 cites W2011927381 @default.
- W2100244098 cites W2022539296 @default.
- W2100244098 cites W2033176936 @default.
- W2100244098 cites W2038822138 @default.
- W2100244098 cites W2047172111 @default.
- W2100244098 cites W2047717681 @default.
- W2100244098 cites W2062216067 @default.
- W2100244098 cites W2071553665 @default.
- W2100244098 cites W2079504515 @default.
- W2100244098 cites W2090771134 @default.
- W2100244098 cites W2094360660 @default.
- W2100244098 cites W2148182857 @default.
- W2100244098 cites W2151492430 @default.
- W2100244098 cites W2152621716 @default.
- W2100244098 cites W2156523657 @default.
- W2100244098 doi "https://doi.org/10.3109/0886022x.2010.536606" @default.
- W2100244098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21219207" @default.
- W2100244098 hasPublicationYear "2011" @default.
- W2100244098 type Work @default.
- W2100244098 sameAs 2100244098 @default.
- W2100244098 citedByCount "4" @default.
- W2100244098 countsByYear W21002440982012 @default.
- W2100244098 countsByYear W21002440982013 @default.
- W2100244098 countsByYear W21002440982016 @default.
- W2100244098 countsByYear W21002440982020 @default.
- W2100244098 crossrefType "journal-article" @default.
- W2100244098 hasAuthorship W2100244098A5031069675 @default.
- W2100244098 hasAuthorship W2100244098A5031287265 @default.
- W2100244098 hasAuthorship W2100244098A5045435513 @default.
- W2100244098 hasBestOaLocation W21002440981 @default.
- W2100244098 hasConcept C126322002 @default.
- W2100244098 hasConcept C134018914 @default.
- W2100244098 hasConcept C151400659 @default.
- W2100244098 hasConcept C181199279 @default.
- W2100244098 hasConcept C2775838275 @default.
- W2100244098 hasConcept C2776151105 @default.
- W2100244098 hasConcept C2778102346 @default.
- W2100244098 hasConcept C2778401633 @default.
- W2100244098 hasConcept C2780091579 @default.
- W2100244098 hasConcept C2780261098 @default.
- W2100244098 hasConcept C2781099255 @default.
- W2100244098 hasConcept C55493867 @default.
- W2100244098 hasConcept C71924100 @default.
- W2100244098 hasConcept C86803240 @default.
- W2100244098 hasConceptScore W2100244098C126322002 @default.
- W2100244098 hasConceptScore W2100244098C134018914 @default.
- W2100244098 hasConceptScore W2100244098C151400659 @default.
- W2100244098 hasConceptScore W2100244098C181199279 @default.
- W2100244098 hasConceptScore W2100244098C2775838275 @default.
- W2100244098 hasConceptScore W2100244098C2776151105 @default.
- W2100244098 hasConceptScore W2100244098C2778102346 @default.
- W2100244098 hasConceptScore W2100244098C2778401633 @default.
- W2100244098 hasConceptScore W2100244098C2780091579 @default.
- W2100244098 hasConceptScore W2100244098C2780261098 @default.
- W2100244098 hasConceptScore W2100244098C2781099255 @default.
- W2100244098 hasConceptScore W2100244098C55493867 @default.
- W2100244098 hasConceptScore W2100244098C71924100 @default.
- W2100244098 hasConceptScore W2100244098C86803240 @default.
- W2100244098 hasIssue "1" @default.
- W2100244098 hasLocation W21002440981 @default.
- W2100244098 hasLocation W21002440982 @default.
- W2100244098 hasOpenAccess W2100244098 @default.
- W2100244098 hasPrimaryLocation W21002440981 @default.
- W2100244098 hasRelatedWork W159649112 @default.
- W2100244098 hasRelatedWork W2042147930 @default.
- W2100244098 hasRelatedWork W2057231029 @default.
- W2100244098 hasRelatedWork W2114651971 @default.
- W2100244098 hasRelatedWork W2168524120 @default.
- W2100244098 hasRelatedWork W2335873842 @default.
- W2100244098 hasRelatedWork W2372408108 @default.
- W2100244098 hasRelatedWork W2383287079 @default.
- W2100244098 hasRelatedWork W2389959060 @default.
- W2100244098 hasRelatedWork W27940272 @default.
- W2100244098 hasVolume "33" @default.
- W2100244098 isParatext "false" @default.
- W2100244098 isRetracted "false" @default.
- W2100244098 magId "2100244098" @default.
- W2100244098 workType "article" @default.