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• W2100246023 abstract "ABSTRACT Genetically regulated mechanisms of host defense against Cryptococcus neoformans infection are not well understood. In this study, pulmonary infection with the moderately virulent C. neoformans strain 24067 was used to compare the host resistance phenotype of C57BL/6J with that of inbred mouse strain SJL/J. At 7 days or later after infection, C57BL/6J mice exhibited a significantly greater fungal burden in the lungs than SJL/J mice. Characterization of the pulmonary innate immune response at 3 h after cryptococcal infection revealed that resistant SJL/J mice exhibited significantly higher neutrophilia, with elevated levels of inflammatory cytokine tumor necrosis factor alpha (TNF-α) and keratinocyte-derived chemokine (KC)/CXCL1 in the airways, as well as increased whole-lung mRNA expression of chemokines KC/CXCL1, MIP-1α/CCL3, MIP-1β/CCL4, MIP-2/CXCL2, and MCP-1/CCL2 and cytokines interleukin 1β (IL-1β) and IL-1Ra. At 7 and 14 days after infection, SJL/J mice maintained significantly higher levels of TNF-α and KC/CXCL1 in the airways and exhibited a Th1 response characterized by elevated levels of lung gamma interferon (IFN-γ) and IL-12/IL-23p40, while C57BL/6J mice exhibited Th2 immunity as defined by eosinophilia and IL-4 production. Alveolar and resident peritoneal macrophages from SJL/J mice also secreted significantly greater amounts of TNF-α and KC/CXCL1 following in vitro stimulation with C. neoformans . Intracellular signaling analysis demonstrated that TNF-α and KC/CXCL1 production was regulated by NF-κB and phosphatidylinositol 3 kinase in both strains; however, SJL/J macrophages exhibited heightened and prolonged activation in response to C. neoformans infection compared to that of C57BL/6J. Taken together, these data demonstrate that an enhanced innate immune response against pulmonary C. neoformans infection in SJL/J mice is associated with natural resistance to progressive infection." @default.
• W2100246023 created "2016-06-24" @default.
• W2100246023 creator A5001025455 @default.
• W2100246023 creator A5033097567 @default.
• W2100246023 creator A5054169058 @default.
• W2100246023 creator A5066370335 @default.
• W2100246023 date "2008-10-01" @default.
• W2100246023 modified "2023-10-13" @default.
• W2100246023 title "Enhanced Innate Immune Responsiveness to Pulmonary<i>Cryptococcus neoformans</i>Infection Is Associated with Resistance to Progressive Infection" @default.
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• W2100246023 doi "https://doi.org/10.1128/iai.00341-08" @default.
• W2100246023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2546841" @default.
• W2100246023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18678664" @default.
• W2100246023 hasPublicationYear "2008" @default.
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