FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100256750> ?p ?o ?g. }

• W2100256750 endingPage "3370" @default.
• W2100256750 startingPage "3363" @default.
• W2100256750 abstract "ABSTRACT The Drosophila EGF receptor (DER) is activated by secreted Spitz to induce different cell fates in the ventral ectoderm. Processing of the precursor transmembrane Spitz to generate the secreted form was shown to be the limiting event, but the cells in which processing takes place and the mechanism that may generate a gradient of secreted Spitz in the ectoderm were not known. The ectodermal defects in single minded (sim) mutant embryos, in which the midline fails to develop, suggested that the midline cells contribute to patterning of the ventral ectoderm. This work shows that the midline provides the site for Spitz expression and processing. The Rhomboid and Star proteins are also expressed and required in the midline. The ectodermal defects of spitz, rho or Star mutant embryos could be rescued by inducing the expression of the respective normal genes only in the midline cells. Rho and Star thus function non-autonomously, and may be required for the production or processing of the Spitz precursor. Secreted Spitz is the only sim-dependent contribution of the midline to patterning the ectoderm, since the ventral defects observed in sim mutant embryos can be overcome by expression of secreted Spitz in the ectoderm. While ectopic expression of secreted Spitz in the ectoderm or mesoderm gave rise to ventralization of the embryo, increased expression of secreted Spitz in the midline did not lead to alterations in ectoderm patterning. A mechanism for adjustment to variable levels of secreted Spitz emanating from the midline may be provided by Argos, which forms an inhibitory feedback loop for DER activation. The production of secreted Spitz in the midline, may provide a stable source for graded DER activation in the ventral ectoderm." @default.
• W2100256750 created "2016-06-24" @default.
• W2100256750 creator A5032460765 @default.
• W2100256750 creator A5080438521 @default.
• W2100256750 creator A5081280205 @default.
• W2100256750 date "1996-11-01" @default.
• W2100256750 modified "2023-10-13" @default.
• W2100256750 title "The <i>Drosophila</i> embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm" @default.
• W2100256750 cites W1838499744 @default.
• W2100256750 cites W1892595506 @default.
• W2100256750 cites W1966119641 @default.
• W2100256750 cites W1982483908 @default.
• W2100256750 cites W1990152822 @default.
• W2100256750 cites W1996775753 @default.
• W2100256750 cites W2003460583 @default.
• W2100256750 cites W2008126806 @default.
• W2100256750 cites W2008482750 @default.
• W2100256750 cites W2017133589 @default.
• W2100256750 cites W2017485209 @default.
• W2100256750 cites W2017702115 @default.
• W2100256750 cites W2021554803 @default.
• W2100256750 cites W2032157793 @default.
• W2100256750 cites W2033582979 @default.
• W2100256750 cites W2035595923 @default.
• W2100256750 cites W2036207377 @default.
• W2100256750 cites W2038560503 @default.
• W2100256750 cites W2043644025 @default.
• W2100256750 cites W2048917073 @default.
• W2100256750 cites W2056129229 @default.
• W2100256750 cites W2057989418 @default.
• W2100256750 cites W2064387879 @default.
• W2100256750 cites W2068930339 @default.
• W2100256750 cites W2086248842 @default.
• W2100256750 cites W2088658701 @default.
• W2100256750 cites W2102722477 @default.
• W2100256750 cites W2108908409 @default.
• W2100256750 cites W2110643873 @default.
• W2100256750 cites W2111976316 @default.
• W2100256750 cites W2116577449 @default.
• W2100256750 cites W2145493607 @default.
• W2100256750 cites W2149348614 @default.
• W2100256750 cites W2161990131 @default.
• W2100256750 cites W2164655389 @default.
• W2100256750 cites W2172086325 @default.
• W2100256750 cites W2186225761 @default.
• W2100256750 cites W2280399959 @default.
• W2100256750 cites W2409484866 @default.
• W2100256750 cites W4297673475 @default.
• W2100256750 doi "https://doi.org/10.1242/dev.122.11.3363" @default.
• W2100256750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8951053" @default.
• W2100256750 hasPublicationYear "1996" @default.
• W2100256750 type Work @default.
• W2100256750 sameAs 2100256750 @default.
• W2100256750 citedByCount "217" @default.
• W2100256750 countsByYear W21002567502012 @default.
• W2100256750 countsByYear W21002567502013 @default.
• W2100256750 countsByYear W21002567502014 @default.
• W2100256750 countsByYear W21002567502015 @default.
• W2100256750 countsByYear W21002567502016 @default.
• W2100256750 countsByYear W21002567502017 @default.
• W2100256750 countsByYear W21002567502018 @default.
• W2100256750 countsByYear W21002567502019 @default.
• W2100256750 countsByYear W21002567502021 @default.
• W2100256750 countsByYear W21002567502022 @default.
• W2100256750 countsByYear W21002567502023 @default.
• W2100256750 crossrefType "journal-article" @default.
• W2100256750 hasAuthorship W2100256750A5032460765 @default.
• W2100256750 hasAuthorship W2100256750A5080438521 @default.
• W2100256750 hasAuthorship W2100256750A5081280205 @default.
• W2100256750 hasConcept C104317684 @default.
• W2100256750 hasConcept C105702510 @default.
• W2100256750 hasConcept C114696181 @default.
• W2100256750 hasConcept C127716648 @default.
• W2100256750 hasConcept C145103041 @default.
• W2100256750 hasConcept C196843134 @default.
• W2100256750 hasConcept C2779329299 @default.
• W2100256750 hasConcept C2780915607 @default.
• W2100256750 hasConcept C54355233 @default.
• W2100256750 hasConcept C86803240 @default.
• W2100256750 hasConcept C87073359 @default.
• W2100256750 hasConcept C95444343 @default.
• W2100256750 hasConcept C97037327 @default.
• W2100256750 hasConceptScore W2100256750C104317684 @default.
• W2100256750 hasConceptScore W2100256750C105702510 @default.
• W2100256750 hasConceptScore W2100256750C114696181 @default.
• W2100256750 hasConceptScore W2100256750C127716648 @default.
• W2100256750 hasConceptScore W2100256750C145103041 @default.
• W2100256750 hasConceptScore W2100256750C196843134 @default.
• W2100256750 hasConceptScore W2100256750C2779329299 @default.
• W2100256750 hasConceptScore W2100256750C2780915607 @default.
• W2100256750 hasConceptScore W2100256750C54355233 @default.
• W2100256750 hasConceptScore W2100256750C86803240 @default.
• W2100256750 hasConceptScore W2100256750C87073359 @default.
• W2100256750 hasConceptScore W2100256750C95444343 @default.
• W2100256750 hasConceptScore W2100256750C97037327 @default.
• W2100256750 hasIssue "11" @default.
• W2100256750 hasLocation W21002567501 @default.
• W2100256750 hasLocation W21002567502 @default.

• next