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- W2100267148 abstract "In recent years, significant progress has been made in the treatment of rheumatoid arthritis (RA). In addition to conventional therapy, novel biologicals targeting tumour necrosis factor-alpha have successfully entered the clinic. However, the majority of the patients still has some actively inflamed joints and some patients suffer from side-effects associated with the high systemic dosages needed to achieve therapeutic levels in the joints. In addition, due to of the short half-life of these proteins there is a need for continuous, multiple injections of the recombinant protein. An alternative approach might be the use of gene transfer to deliver therapeutic genes locally at the site of inflammation. Several viral and non-viral vectors are being used in animal models of RA. The first gene therapy trials for RA have already entered the clinic. New vectors inducing long-term and regulated gene expression in specific tissue are under development, resulting in more efficient gene transfer, for example by using distinct serotypes of viral vectors such as adeno-associated virus. This review gives an overview of some promising vectors used in RA research. Furthermore, several therapeutic genes are discussed that could be used for gene therapy in RA patients." @default.
- W2100267148 created "2016-06-24" @default.
- W2100267148 creator A5012564728 @default.
- W2100267148 creator A5026384921 @default.
- W2100267148 creator A5044290531 @default.
- W2100267148 date "2006-03-01" @default.
- W2100267148 modified "2023-10-18" @default.
- W2100267148 title "Gene therapy as a therapeutic approach for the treatment of rheumatoid arthritis: innovative vectors and therapeutic genes" @default.
- W2100267148 cites W132781887 @default.
- W2100267148 cites W1488961672 @default.
- W2100267148 cites W1491615287 @default.
- W2100267148 cites W1494879100 @default.
- W2100267148 cites W1503366574 @default.
- W2100267148 cites W1513061841 @default.
- W2100267148 cites W1522287604 @default.
- W2100267148 cites W1523595999 @default.
- W2100267148 cites W1530030540 @default.
- W2100267148 cites W1544034668 @default.
- W2100267148 cites W1554330891 @default.
- W2100267148 cites W1582728933 @default.
- W2100267148 cites W1598188453 @default.
- W2100267148 cites W1604626968 @default.
- W2100267148 cites W1657750667 @default.
- W2100267148 cites W1675918302 @default.
- W2100267148 cites W1722673048 @default.
- W2100267148 cites W1859542580 @default.
- W2100267148 cites W1886972027 @default.
- W2100267148 cites W1887346136 @default.
- W2100267148 cites W1929630117 @default.
- W2100267148 cites W1943985333 @default.
- W2100267148 cites W1963548145 @default.
- W2100267148 cites W1963623233 @default.
- W2100267148 cites W1965105897 @default.
- W2100267148 cites W1967929135 @default.
- W2100267148 cites W1969475775 @default.
- W2100267148 cites W1971050137 @default.
- W2100267148 cites W1971371421 @default.
- W2100267148 cites W1971921768 @default.
- W2100267148 cites W1972564575 @default.
- W2100267148 cites W1973469936 @default.
- W2100267148 cites W1974147843 @default.
- W2100267148 cites W1975528602 @default.
- W2100267148 cites W1977797303 @default.
- W2100267148 cites W1978103379 @default.
- W2100267148 cites W1979520552 @default.
- W2100267148 cites W1981033558 @default.
- W2100267148 cites W1984376606 @default.
- W2100267148 cites W1984907444 @default.
- W2100267148 cites W1990065831 @default.
- W2100267148 cites W1990561446 @default.
- W2100267148 cites W1991789941 @default.
- W2100267148 cites W1994678537 @default.
- W2100267148 cites W1997266231 @default.
- W2100267148 cites W2001657410 @default.
- W2100267148 cites W2002037947 @default.
- W2100267148 cites W2003456064 @default.
- W2100267148 cites W2004983645 @default.
- W2100267148 cites W2005275397 @default.
- W2100267148 cites W2005344589 @default.
- W2100267148 cites W2007854533 @default.
- W2100267148 cites W2010123009 @default.
- W2100267148 cites W2011614484 @default.
- W2100267148 cites W2012055659 @default.
- W2100267148 cites W2014049978 @default.
- W2100267148 cites W2014334443 @default.
- W2100267148 cites W2016004071 @default.
- W2100267148 cites W2017608179 @default.
- W2100267148 cites W2017888326 @default.
- W2100267148 cites W2018554367 @default.
- W2100267148 cites W2019675509 @default.
- W2100267148 cites W2019971607 @default.
- W2100267148 cites W2020799981 @default.
- W2100267148 cites W2021113530 @default.
- W2100267148 cites W2022351216 @default.
- W2100267148 cites W2023254910 @default.
- W2100267148 cites W2023289572 @default.
- W2100267148 cites W2024264704 @default.
- W2100267148 cites W2024522405 @default.
- W2100267148 cites W2027661777 @default.
- W2100267148 cites W2029134792 @default.
- W2100267148 cites W2031092466 @default.
- W2100267148 cites W2032591467 @default.
- W2100267148 cites W2035180752 @default.
- W2100267148 cites W2035919002 @default.
- W2100267148 cites W2036346583 @default.
- W2100267148 cites W2041454388 @default.
- W2100267148 cites W2042131554 @default.
- W2100267148 cites W2042666390 @default.
- W2100267148 cites W2044075792 @default.
- W2100267148 cites W2046621489 @default.
- W2100267148 cites W2046846784 @default.
- W2100267148 cites W2047127326 @default.
- W2100267148 cites W2047516372 @default.
- W2100267148 cites W2047608515 @default.
- W2100267148 cites W2047667011 @default.
- W2100267148 cites W2048008983 @default.
- W2100267148 cites W2049213877 @default.
- W2100267148 cites W2049958940 @default.