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• W2100276657 abstract "We previously reported a novel interaction between v-Crk and myosin-1c, and demonstrated that this interaction is essential for cell migration, even in the absence of p130CAS. We here demonstrate a role for Crk-myosin-1c interaction in cell adhesion and spreading. Crk-knockout (Crk ⁻/⁻) mouse embryo fibroblasts (MEFs) exhibited significantly decreased cell spreading and reduced Rac1 activity. A stroboscopic analysis of cell dynamics during cell spreading revealed that the cell-spreading deficiency in Crk⁻/⁻ MEFs was due to the short protrusion/retraction distances and long persistence times of membrane extensions. The low activity of Rac1 in Crk⁻/⁻ MEFs, which led to delayed cell spreading in these cells, is consistent with the observed defects in membrane dynamics. Reintroduction of v-Crk into Crk⁻/⁻ MEFs rescued these defects, restoring cell-spreading activity and membrane dynamics to Crk⁺/⁺ MEF levels, and normalizing Rac1 activity. Knockdown of myosin-1c by introduction of small interfering RNA resulted in a delay in cell spreading and reduced Rac1 activity to low levels, suggesting that myosin-1c also plays an essential role in cell adhesion and spreading. In addition, deletion of the v-Crk SH3 domain, which interacts with the myosin-1c tail, led to defects in cell spreading. Overexpression of the GFP-myosin-1c tail domain effectively inhibited the v-Crk-myosin-1c interaction and led to a slight decrease in cell spreading and cell surface area. Collectively, these findings suggest that the v-Crk-myosin-1c interaction, which modulates membrane dynamics by regulating Rac1 activity, is crucial for cell adhesion and spreading." @default.
• W2100276657 created "2016-06-24" @default.
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• W2100276657 date "2013-01-01" @default.
• W2100276657 modified "2023-10-01" @default.
• W2100276657 title "Interaction of Crk with Myosin-1c Participates in Fibronectin-Induced Cell Spreading" @default.
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• W2100276657 doi "https://doi.org/10.7150/ijbs.6459" @default.
• W2100276657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3753442" @default.
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