Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100278510> ?p ?o ?g. }
- W2100278510 endingPage "4044" @default.
- W2100278510 startingPage "4044" @default.
- W2100278510 abstract "To determine the effect of triple drug immune suppression on RPE xenograft survival in the fetal pig after transplantation into the albino rabbit subretinal space.Primary RPE microaggregates (approximately 40,000 RPE cells) were injected into the subretinal space of 24 albino rabbits, with half the rabbits maintained on triple systemic immune suppression. RPE survival was estimated with a DNA probe (porcine DNA repeat element; PRE) against a porcine-specific repetitive chromosomal marker or a RAM-11 antibody against rabbit macrophages.Numerous pigmented cells were visible in the subretinal space at all time points, but most pigment-containing cells 4 weeks or more after surgery were RAM-11 positive and PRE negative. The number of PRE-positive cells in the immune-suppressed group (4193 +/- 2461, 1184 +/- 1502, and 541 +/- 324 at 4, 8, and 12 weeks, respectively) was greater than in immune-competent control animals (292 +/- 506, 193 +/- 173, and 111 +/- 96), but the difference was only statistically significant at 4 weeks. The time-dependent decrease in PRE-positive cells was more pronounced in immune-suppressed animals. Image analysis performed on serial fundus photographs and fluorescein angiograms did not detect any difference in the appearance of the grafts in immune-suppressed versus immune-competent animals.Systemic immune suppression increased the 4-week survival of porcine RPE xenografts in the albino rabbit subretinal space, but there was poor survival in immune-suppressed and -competent animals 12 weeks after surgery. Many pigment-containing cells 4 or more weeks after surgery were PRE negative, indicating that they are of host origin." @default.
- W2100278510 created "2016-06-24" @default.
- W2100278510 creator A5006293409 @default.
- W2100278510 creator A5018390486 @default.
- W2100278510 creator A5034104351 @default.
- W2100278510 creator A5036144206 @default.
- W2100278510 creator A5045943924 @default.
- W2100278510 creator A5048319921 @default.
- W2100278510 creator A5076196980 @default.
- W2100278510 creator A5081736910 @default.
- W2100278510 date "2003-09-01" @default.
- W2100278510 modified "2023-10-16" @default.
- W2100278510 title "Triple Immune Suppression Increases Short-Term Survival of Porcine Fetal Retinal Pigment Epithelium Xenografts" @default.
- W2100278510 cites W126134659 @default.
- W2100278510 cites W1486869415 @default.
- W2100278510 cites W1491905380 @default.
- W2100278510 cites W1516250834 @default.
- W2100278510 cites W1569363854 @default.
- W2100278510 cites W1570428536 @default.
- W2100278510 cites W1581940649 @default.
- W2100278510 cites W172038290 @default.
- W2100278510 cites W177197865 @default.
- W2100278510 cites W1868984124 @default.
- W2100278510 cites W1926534590 @default.
- W2100278510 cites W1968225888 @default.
- W2100278510 cites W1971555156 @default.
- W2100278510 cites W1979182288 @default.
- W2100278510 cites W1987429671 @default.
- W2100278510 cites W1987685756 @default.
- W2100278510 cites W1991544676 @default.
- W2100278510 cites W1993096645 @default.
- W2100278510 cites W1993291137 @default.
- W2100278510 cites W1996396562 @default.
- W2100278510 cites W2001248401 @default.
- W2100278510 cites W2002541850 @default.
- W2100278510 cites W2003428013 @default.
- W2100278510 cites W2003788960 @default.
- W2100278510 cites W2005092908 @default.
- W2100278510 cites W2005210876 @default.
- W2100278510 cites W2005710544 @default.
- W2100278510 cites W2007516625 @default.
- W2100278510 cites W2007885212 @default.
- W2100278510 cites W2011752292 @default.
- W2100278510 cites W2016293470 @default.
- W2100278510 cites W2017129750 @default.
- W2100278510 cites W2017530678 @default.
- W2100278510 cites W2019609676 @default.
- W2100278510 cites W2023735529 @default.
- W2100278510 cites W2029073745 @default.
- W2100278510 cites W2029872233 @default.
- W2100278510 cites W2033414925 @default.
- W2100278510 cites W2034018544 @default.
- W2100278510 cites W2037915677 @default.
- W2100278510 cites W2037981730 @default.
- W2100278510 cites W2038420185 @default.
- W2100278510 cites W2041105082 @default.
- W2100278510 cites W2046429383 @default.
- W2100278510 cites W2048107972 @default.
- W2100278510 cites W2048560811 @default.
- W2100278510 cites W2048854714 @default.
- W2100278510 cites W2049342495 @default.
- W2100278510 cites W2049531589 @default.
- W2100278510 cites W2052946966 @default.
- W2100278510 cites W2059444795 @default.
- W2100278510 cites W2067072602 @default.
- W2100278510 cites W2070605817 @default.
- W2100278510 cites W2070726002 @default.
- W2100278510 cites W2075115097 @default.
- W2100278510 cites W2076625033 @default.
- W2100278510 cites W2079059134 @default.
- W2100278510 cites W2079368490 @default.
- W2100278510 cites W2083898031 @default.
- W2100278510 cites W2084814985 @default.
- W2100278510 cites W2099736751 @default.
- W2100278510 cites W2105965944 @default.
- W2100278510 cites W2114268866 @default.
- W2100278510 cites W2126213714 @default.
- W2100278510 cites W2140213338 @default.
- W2100278510 cites W2141210116 @default.
- W2100278510 cites W2148936029 @default.
- W2100278510 cites W2149208246 @default.
- W2100278510 cites W2150113465 @default.
- W2100278510 cites W2158854019 @default.
- W2100278510 cites W2164175268 @default.
- W2100278510 cites W2166245251 @default.
- W2100278510 cites W2166711233 @default.
- W2100278510 cites W2190037631 @default.
- W2100278510 cites W2409633920 @default.
- W2100278510 cites W2409644553 @default.
- W2100278510 cites W2411291550 @default.
- W2100278510 cites W2412632174 @default.
- W2100278510 cites W2414739315 @default.
- W2100278510 cites W2418423387 @default.
- W2100278510 cites W2418641299 @default.
- W2100278510 cites W2423792649 @default.
- W2100278510 cites W2430139870 @default.
- W2100278510 cites W2466947516 @default.
- W2100278510 cites W2467875808 @default.