FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100285612> ?p ?o ?g. }

• W2100285612 endingPage "339" @default.
• W2100285612 startingPage "333" @default.
• W2100285612 abstract "Background. Angiogenesis is a prerequisite for tumor growth and metastasis. Tumor angiogenesis may be mediated by several angiogenic factors such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), transforming growth factor-α, and basic fibroblast growth factor. Methods. Differential mRNA expressions of VEGF, PDGF (A chain), transforming growth factor-α, and basic fibroblast growth factor in 32 primary invasive breast tumors were examined by reverse transcriptase-polymerase chain reaction. We analyzed relationships between mRNA expressions of these angiogenic factors and the degree of angiogenesis, tumor size, and metastasis. Quantification of angiogenesis was achieved by the immunohistochemical staining of endothelial cells with antibody to CD31. Results. VEGF and PDGF-A mRNAs were expressed more frequently in breast tumors than in nontumor breast tissues, whereas no difference was found in expression frequency of either transforming growth factor-α or basic fibroblast growth factor mRNA. Vascular counts in tumors correlated with each expression frequency of VEGF and PDGF-A mRNA. PDGF-A mRNA was expressed more frequently in tumors with lymph node metastasis than in those without metastasis. Conclusions. Expression of VEGF and PDGF mRNAs detected by reverse transcriptase-polymerase chain reaction in breast tumors correlates with tumor-related characteristics of angiogenesis and metastatic potential. Analysis of these mRNAs by reverse transcriptase-polymerase chain reaction may be useful for assessing the biologic behavior of a breast tumor before surgical treatment. Background. Angiogenesis is a prerequisite for tumor growth and metastasis. Tumor angiogenesis may be mediated by several angiogenic factors such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), transforming growth factor-α, and basic fibroblast growth factor. Methods. Differential mRNA expressions of VEGF, PDGF (A chain), transforming growth factor-α, and basic fibroblast growth factor in 32 primary invasive breast tumors were examined by reverse transcriptase-polymerase chain reaction. We analyzed relationships between mRNA expressions of these angiogenic factors and the degree of angiogenesis, tumor size, and metastasis. Quantification of angiogenesis was achieved by the immunohistochemical staining of endothelial cells with antibody to CD31. Results. VEGF and PDGF-A mRNAs were expressed more frequently in breast tumors than in nontumor breast tissues, whereas no difference was found in expression frequency of either transforming growth factor-α or basic fibroblast growth factor mRNA. Vascular counts in tumors correlated with each expression frequency of VEGF and PDGF-A mRNA. PDGF-A mRNA was expressed more frequently in tumors with lymph node metastasis than in those without metastasis. Conclusions. Expression of VEGF and PDGF mRNAs detected by reverse transcriptase-polymerase chain reaction in breast tumors correlates with tumor-related characteristics of angiogenesis and metastatic potential. Analysis of these mRNAs by reverse transcriptase-polymerase chain reaction may be useful for assessing the biologic behavior of a breast tumor before surgical treatment." @default.
• W2100285612 created "2016-06-24" @default.
• W2100285612 creator A5031287409 @default.
• W2100285612 creator A5052684223 @default.
• W2100285612 creator A5063072706 @default.
• W2100285612 creator A5068600822 @default.
• W2100285612 creator A5078409741 @default.
• W2100285612 creator A5078418006 @default.
• W2100285612 creator A5082094461 @default.
• W2100285612 creator A5082648609 @default.
• W2100285612 creator A5091882168 @default.
• W2100285612 date "1996-03-01" @default.
• W2100285612 modified "2023-09-23" @default.
• W2100285612 title "Vascular endothelial growth factor and platelet-derived growth factor are potential angiogenic and metastatic factors in human breast cancer" @default.
• W2100285612 cites W1596449567 @default.
• W2100285612 cites W1624346216 @default.
• W2100285612 cites W1948307417 @default.
• W2100285612 cites W1969328947 @default.
• W2100285612 cites W1970516412 @default.
• W2100285612 cites W1978414947 @default.
• W2100285612 cites W1988978946 @default.
• W2100285612 cites W1990494772 @default.
• W2100285612 cites W1992158081 @default.
• W2100285612 cites W2011957331 @default.
• W2100285612 cites W2026151657 @default.
• W2100285612 cites W2030191440 @default.
• W2100285612 cites W2040906663 @default.
• W2100285612 cites W2043863730 @default.
• W2100285612 cites W2072928113 @default.
• W2100285612 cites W2074070420 @default.
• W2100285612 cites W2096428903 @default.
• W2100285612 cites W2100088344 @default.
• W2100285612 cites W2103824592 @default.
• W2100285612 cites W2108145145 @default.
• W2100285612 cites W2128782161 @default.
• W2100285612 cites W2158743409 @default.
• W2100285612 cites W2163380244 @default.
• W2100285612 cites W2319962899 @default.
• W2100285612 cites W4255042798 @default.
• W2100285612 doi "https://doi.org/10.1016/s0039-6060(96)80120-6" @default.
• W2100285612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8619189" @default.
• W2100285612 hasPublicationYear "1996" @default.
• W2100285612 type Work @default.
• W2100285612 sameAs 2100285612 @default.
• W2100285612 citedByCount "158" @default.
• W2100285612 countsByYear W21002856122012 @default.
• W2100285612 countsByYear W21002856122013 @default.
• W2100285612 countsByYear W21002856122014 @default.
• W2100285612 countsByYear W21002856122015 @default.
• W2100285612 countsByYear W21002856122016 @default.
• W2100285612 countsByYear W21002856122017 @default.
• W2100285612 countsByYear W21002856122018 @default.
• W2100285612 countsByYear W21002856122020 @default.
• W2100285612 countsByYear W21002856122021 @default.
• W2100285612 countsByYear W21002856122022 @default.
• W2100285612 countsByYear W21002856122023 @default.
• W2100285612 crossrefType "journal-article" @default.
• W2100285612 hasAuthorship W2100285612A5031287409 @default.
• W2100285612 hasAuthorship W2100285612A5052684223 @default.
• W2100285612 hasAuthorship W2100285612A5063072706 @default.
• W2100285612 hasAuthorship W2100285612A5068600822 @default.
• W2100285612 hasAuthorship W2100285612A5078409741 @default.
• W2100285612 hasAuthorship W2100285612A5078418006 @default.
• W2100285612 hasAuthorship W2100285612A5082094461 @default.
• W2100285612 hasAuthorship W2100285612A5082648609 @default.
• W2100285612 hasAuthorship W2100285612A5091882168 @default.
• W2100285612 hasConcept C103041312 @default.
• W2100285612 hasConcept C121608353 @default.
• W2100285612 hasConcept C126322002 @default.
• W2100285612 hasConcept C142724271 @default.
• W2100285612 hasConcept C146285616 @default.
• W2100285612 hasConcept C167734588 @default.
• W2100285612 hasConcept C170493617 @default.
• W2100285612 hasConcept C180361614 @default.
• W2100285612 hasConcept C2775960820 @default.
• W2100285612 hasConcept C2777025900 @default.
• W2100285612 hasConcept C2777587049 @default.
• W2100285612 hasConcept C2779013556 @default.
• W2100285612 hasConcept C2780394083 @default.
• W2100285612 hasConcept C2781294074 @default.
• W2100285612 hasConcept C502942594 @default.
• W2100285612 hasConcept C71924100 @default.
• W2100285612 hasConceptScore W2100285612C103041312 @default.
• W2100285612 hasConceptScore W2100285612C121608353 @default.
• W2100285612 hasConceptScore W2100285612C126322002 @default.
• W2100285612 hasConceptScore W2100285612C142724271 @default.
• W2100285612 hasConceptScore W2100285612C146285616 @default.
• W2100285612 hasConceptScore W2100285612C167734588 @default.
• W2100285612 hasConceptScore W2100285612C170493617 @default.
• W2100285612 hasConceptScore W2100285612C180361614 @default.
• W2100285612 hasConceptScore W2100285612C2775960820 @default.
• W2100285612 hasConceptScore W2100285612C2777025900 @default.
• W2100285612 hasConceptScore W2100285612C2777587049 @default.
• W2100285612 hasConceptScore W2100285612C2779013556 @default.
• W2100285612 hasConceptScore W2100285612C2780394083 @default.
• W2100285612 hasConceptScore W2100285612C2781294074 @default.
• W2100285612 hasConceptScore W2100285612C502942594 @default.
• W2100285612 hasConceptScore W2100285612C71924100 @default.

• next