Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100286618> ?p ?o ?g. }
- W2100286618 endingPage "145" @default.
- W2100286618 startingPage "140" @default.
- W2100286618 abstract "Aims: The present study explored whether specific single-nucleotide polymorphisms in alcohol metabolic pathway are associated with alcohol dependence or alcohol-related psychopathological symptoms. Methods: Three groups of male unrelated subjects were included: 101 currently alcohol-dependent patients, 100 formerly alcohol-dependent subjects and 97 healthy controls. The following questionnaires were implemented: AUDIT, Zung Depression and Anxiety scale, Brief Social Phobia Scale, Yale-Brown Obsessive Compulsive Scale, Obsessive Compulsive Drinking Scale and Buss-Durkee Hostility Inventory. All the subjects were genotyped for CYP2E1 c.-1053C>T and CAT c.-262C>T. Results: Statistically significant differences in the distribution of genotypes and alleles for CAT c.-262C>T polymorphism were observed among the three investigated groups. We observed a higher frequency of CAT -262T allele in alcohol-dependent subjects (OR = 1.74, 95% CI = 1.164–2.610). Among currently dependent patients CAT -262T allele carriers had higher AUDIT scores (P = 0.023), while CYP2E1-1053T allele carriers had significantly higher YBOCS-obsession subscale scores (P = 0.005) and Zung Anxiety Scale scores (P = 0.011). Conclusions: Our findings suggest that the CAT c.-262C>T genetic polymorphism influences the susceptibility to alcohol dependence and severity of alcohol dependence, while CYP2E1 c.-1053C>T polymorphism influences the expression of obsessive–compulsive and anxiety symptoms." @default.
- W2100286618 created "2016-06-24" @default.
- W2100286618 creator A5003084505 @default.
- W2100286618 creator A5014769991 @default.
- W2100286618 creator A5048915850 @default.
- W2100286618 creator A5062596209 @default.
- W2100286618 creator A5068534236 @default.
- W2100286618 creator A5070460335 @default.
- W2100286618 creator A5081878791 @default.
- W2100286618 date "2014-12-16" @default.
- W2100286618 modified "2023-09-26" @default.
- W2100286618 title "Genetic Variability in CYP2E1 and Catalase Gene Among Currently and Formerly Alcohol-Dependent Male Subjects" @default.
- W2100286618 cites W1507335601 @default.
- W2100286618 cites W1895595836 @default.
- W2100286618 cites W1930085052 @default.
- W2100286618 cites W1971990056 @default.
- W2100286618 cites W1974384388 @default.
- W2100286618 cites W1975147863 @default.
- W2100286618 cites W1975387389 @default.
- W2100286618 cites W1983472283 @default.
- W2100286618 cites W1986185899 @default.
- W2100286618 cites W1987867682 @default.
- W2100286618 cites W1989463289 @default.
- W2100286618 cites W1995146482 @default.
- W2100286618 cites W2012341042 @default.
- W2100286618 cites W2021395331 @default.
- W2100286618 cites W2022202078 @default.
- W2100286618 cites W2022460877 @default.
- W2100286618 cites W2038780654 @default.
- W2100286618 cites W2045310665 @default.
- W2100286618 cites W2045763937 @default.
- W2100286618 cites W2055913792 @default.
- W2100286618 cites W2056926634 @default.
- W2100286618 cites W2072059188 @default.
- W2100286618 cites W2072157296 @default.
- W2100286618 cites W2073811030 @default.
- W2100286618 cites W2081482754 @default.
- W2100286618 cites W2085065683 @default.
- W2100286618 cites W2105590950 @default.
- W2100286618 cites W2116003431 @default.
- W2100286618 cites W2121566315 @default.
- W2100286618 cites W2128794003 @default.
- W2100286618 cites W2131313431 @default.
- W2100286618 cites W2138624018 @default.
- W2100286618 cites W2140691130 @default.
- W2100286618 cites W2145377013 @default.
- W2100286618 cites W2153353815 @default.
- W2100286618 cites W2168185888 @default.
- W2100286618 cites W2170332928 @default.
- W2100286618 cites W4294307687 @default.
- W2100286618 doi "https://doi.org/10.1093/alcalc/agu088" @default.
- W2100286618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25514903" @default.
- W2100286618 hasPublicationYear "2014" @default.
- W2100286618 type Work @default.
- W2100286618 sameAs 2100286618 @default.
- W2100286618 citedByCount "24" @default.
- W2100286618 countsByYear W21002866182015 @default.
- W2100286618 countsByYear W21002866182016 @default.
- W2100286618 countsByYear W21002866182017 @default.
- W2100286618 countsByYear W21002866182018 @default.
- W2100286618 countsByYear W21002866182019 @default.
- W2100286618 countsByYear W21002866182020 @default.
- W2100286618 countsByYear W21002866182021 @default.
- W2100286618 countsByYear W21002866182022 @default.
- W2100286618 countsByYear W21002866182023 @default.
- W2100286618 crossrefType "journal-article" @default.
- W2100286618 hasAuthorship W2100286618A5003084505 @default.
- W2100286618 hasAuthorship W2100286618A5014769991 @default.
- W2100286618 hasAuthorship W2100286618A5048915850 @default.
- W2100286618 hasAuthorship W2100286618A5062596209 @default.
- W2100286618 hasAuthorship W2100286618A5068534236 @default.
- W2100286618 hasAuthorship W2100286618A5070460335 @default.
- W2100286618 hasAuthorship W2100286618A5081878791 @default.
- W2100286618 hasBestOaLocation W21002866181 @default.
- W2100286618 hasConcept C104317684 @default.
- W2100286618 hasConcept C118552586 @default.
- W2100286618 hasConcept C123273963 @default.
- W2100286618 hasConcept C126322002 @default.
- W2100286618 hasConcept C135763542 @default.
- W2100286618 hasConcept C149737253 @default.
- W2100286618 hasConcept C15744967 @default.
- W2100286618 hasConcept C180754005 @default.
- W2100286618 hasConcept C2779436514 @default.
- W2100286618 hasConcept C2781066024 @default.
- W2100286618 hasConcept C2781214261 @default.
- W2100286618 hasConcept C54355233 @default.
- W2100286618 hasConcept C55493867 @default.
- W2100286618 hasConcept C558461103 @default.
- W2100286618 hasConcept C70410870 @default.
- W2100286618 hasConcept C71924100 @default.
- W2100286618 hasConcept C86803240 @default.
- W2100286618 hasConceptScore W2100286618C104317684 @default.
- W2100286618 hasConceptScore W2100286618C118552586 @default.
- W2100286618 hasConceptScore W2100286618C123273963 @default.
- W2100286618 hasConceptScore W2100286618C126322002 @default.
- W2100286618 hasConceptScore W2100286618C135763542 @default.
- W2100286618 hasConceptScore W2100286618C149737253 @default.
- W2100286618 hasConceptScore W2100286618C15744967 @default.