FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100306212> ?p ?o ?g. }

• W2100306212 endingPage "1650" @default.
• W2100306212 startingPage "1641" @default.
• W2100306212 abstract "Mutations in GJB2 (gap junction protein, beta-2) are the major cause of autosomal recessive non-syndromic hearing loss. A few allele variants of this gene also cause autosomal dominant non-syndromic hearing loss as a dominant-negative consequence of expression of the mutant protein. Allele-specific gene suppression by RNA interference (RNAi) is a potentially attractive strategy to prevent hearing loss caused by this mechanism. In this proof-of-principle study, we identified a potent GJB2-targeting short interfering RNA (siRNA) to post-transcriptionally silence the expression of the R75W allele variant of GJB2 in cultured mammalian cells. In a mouse model, this siRNA duplex selectively suppressed GJB2(R75W) expression by >70% of control levels, thereby preventing hearing loss. The level of endogenous murine Gjb2 expression was not affected. Our data show that RNAi can be used with specificity and efficiency in vivo to protect against hearing loss caused as a dominant-negative consequence of mutant gene expression." @default.
• W2100306212 created "2016-06-24" @default.
• W2100306212 creator A5014833790 @default.
• W2100306212 creator A5017040569 @default.
• W2100306212 creator A5023433400 @default.
• W2100306212 creator A5057646685 @default.
• W2100306212 date "2005-04-27" @default.
• W2100306212 modified "2023-09-30" @default.
• W2100306212 title "In vitro and in vivo suppression of GJB2 expression by RNA interference" @default.
• W2100306212 cites W1488192195 @default.
• W2100306212 cites W1532324275 @default.
• W2100306212 cites W1611419331 @default.
• W2100306212 cites W1963768450 @default.
• W2100306212 cites W1980194855 @default.
• W2100306212 cites W1982944995 @default.
• W2100306212 cites W1984109071 @default.
• W2100306212 cites W1988142389 @default.
• W2100306212 cites W1991259792 @default.
• W2100306212 cites W1994718834 @default.
• W2100306212 cites W1996163490 @default.
• W2100306212 cites W1998249204 @default.
• W2100306212 cites W2003392971 @default.
• W2100306212 cites W2008759459 @default.
• W2100306212 cites W2009257155 @default.
• W2100306212 cites W2012547585 @default.
• W2100306212 cites W2015491475 @default.
• W2100306212 cites W2019387053 @default.
• W2100306212 cites W2025886249 @default.
• W2100306212 cites W2029653860 @default.
• W2100306212 cites W2031000455 @default.
• W2100306212 cites W2066173314 @default.
• W2100306212 cites W2073537725 @default.
• W2100306212 cites W2081831000 @default.
• W2100306212 cites W2092866020 @default.
• W2100306212 cites W2096018896 @default.
• W2100306212 cites W2100095605 @default.
• W2100306212 cites W2101653431 @default.
• W2100306212 cites W2103113803 @default.
• W2100306212 cites W2104979554 @default.
• W2100306212 cites W2107235611 @default.
• W2100306212 cites W2107941452 @default.
• W2100306212 cites W2116686526 @default.
• W2100306212 cites W2117991391 @default.
• W2100306212 cites W2119015197 @default.
• W2100306212 cites W2119469827 @default.
• W2100306212 cites W2124789276 @default.
• W2100306212 cites W2131514063 @default.
• W2100306212 cites W2131796097 @default.
• W2100306212 cites W2140114390 @default.
• W2100306212 cites W2140786757 @default.
• W2100306212 cites W2143945867 @default.
• W2100306212 cites W2149871164 @default.
• W2100306212 cites W2152993806 @default.
• W2100306212 cites W2154861374 @default.
• W2100306212 cites W2158585306 @default.
• W2100306212 cites W2171109371 @default.
• W2100306212 cites W2172011162 @default.
• W2100306212 cites W2176417291 @default.
• W2100306212 cites W2336994782 @default.
• W2100306212 doi "https://doi.org/10.1093/hmg/ddi172" @default.
• W2100306212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15857852" @default.
• W2100306212 hasPublicationYear "2005" @default.
• W2100306212 type Work @default.
• W2100306212 sameAs 2100306212 @default.
• W2100306212 citedByCount "98" @default.
• W2100306212 countsByYear W21003062122012 @default.
• W2100306212 countsByYear W21003062122013 @default.
• W2100306212 countsByYear W21003062122014 @default.
• W2100306212 countsByYear W21003062122015 @default.
• W2100306212 countsByYear W21003062122016 @default.
• W2100306212 countsByYear W21003062122017 @default.
• W2100306212 countsByYear W21003062122018 @default.
• W2100306212 countsByYear W21003062122019 @default.
• W2100306212 countsByYear W21003062122020 @default.
• W2100306212 countsByYear W21003062122021 @default.
• W2100306212 countsByYear W21003062122022 @default.
• W2100306212 countsByYear W21003062122023 @default.
• W2100306212 crossrefType "journal-article" @default.
• W2100306212 hasAuthorship W2100306212A5014833790 @default.
• W2100306212 hasAuthorship W2100306212A5017040569 @default.
• W2100306212 hasAuthorship W2100306212A5023433400 @default.
• W2100306212 hasAuthorship W2100306212A5057646685 @default.
• W2100306212 hasBestOaLocation W21003062121 @default.
• W2100306212 hasConcept C104317684 @default.
• W2100306212 hasConcept C119056186 @default.
• W2100306212 hasConcept C143065580 @default.
• W2100306212 hasConcept C150194340 @default.
• W2100306212 hasConcept C153911025 @default.
• W2100306212 hasConcept C165864922 @default.
• W2100306212 hasConcept C166703698 @default.
• W2100306212 hasConcept C180754005 @default.
• W2100306212 hasConcept C207001950 @default.
• W2100306212 hasConcept C22615655 @default.
• W2100306212 hasConcept C2780493683 @default.
• W2100306212 hasConcept C54355233 @default.
• W2100306212 hasConcept C548259974 @default.
• W2100306212 hasConcept C67705224 @default.
• W2100306212 hasConcept C71924100 @default.

• next