Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100308045> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2100308045 endingPage "51" @default.
- W2100308045 startingPage "49" @default.
- W2100308045 abstract "Loss of Dendritic HCN1 Subunits Enhances Cortical Excitability and Epileptogenesis. Huang Z, Walker MC, Shah MM. J Neurosci 2009;29(35):10979–10988. Hyperpolarization-activated cation nonselective 1 (HCN1) plasticity in entorhinal cortical (EC) and hippocampal pyramidal cell dendrites is a salient feature of temporal lobe epilepsy. However, the significance remains undetermined. We demonstrate that adult HCN1 null mice are more susceptible to kainic acid-induced seizures. After termination of these with an anticonvulsant, the mice also developed spontaneous behavioral seizures at a significantly more rapid rate than their wild-type littermates. This greater seizure susceptibility was accompanied by increased spontaneous activity in HCN1 -/- EC layer III neurons. Dendritic I h in these neurons was ablated, too. Consequentially, HCN1 -/- dendrites were more excitable, despite having significantly more hyperpolarized resting membrane potentials (RMPs). In addition, the integration of EPSPs was enhanced considerably such that, at normal RMP, a 50 Hz train of EPSPs produced action potentials in HCN1 -/- neurons. As a result of this enhanced pyramidal cell excitability, spontaneous EPSC frequency onto HCN1 -/- neurons was considerably greater than that onto wild types, causing an imbalance between normal excitatory and inhibitory synaptic activity. These results suggest that dendritic HCN channels are likely to play a critical role in regulating cortical pyramidal cell excitability. Furthermore, these findings suggest that the reduction in dendritic HCN1 subunit expression during epileptogenesis is likely to facilitate the disorder." @default.
- W2100308045 created "2016-06-24" @default.
- W2100308045 creator A5023311802 @default.
- W2100308045 date "2010-03-01" @default.
- W2100308045 modified "2023-09-26" @default.
- W2100308045 title "Genetic Loss of HCN1 Channels is Exciting, but is it Epileptic?" @default.
- W2100308045 cites W1952394902 @default.
- W2100308045 cites W1977181457 @default.
- W2100308045 cites W2023298447 @default.
- W2100308045 cites W2037187826 @default.
- W2100308045 cites W2059880102 @default.
- W2100308045 cites W2067446126 @default.
- W2100308045 cites W2078349199 @default.
- W2100308045 cites W2115853505 @default.
- W2100308045 cites W2126855756 @default.
- W2100308045 cites W2150656582 @default.
- W2100308045 cites W2158022157 @default.
- W2100308045 doi "https://doi.org/10.1111/j.1535-7511.2009.01352.x" @default.
- W2100308045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2836478" @default.
- W2100308045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20231924" @default.
- W2100308045 hasPublicationYear "2010" @default.
- W2100308045 type Work @default.
- W2100308045 sameAs 2100308045 @default.
- W2100308045 citedByCount "4" @default.
- W2100308045 countsByYear W21003080452014 @default.
- W2100308045 countsByYear W21003080452015 @default.
- W2100308045 crossrefType "journal-article" @default.
- W2100308045 hasAuthorship W2100308045A5023311802 @default.
- W2100308045 hasBestOaLocation W21003080452 @default.
- W2100308045 hasConcept C112592302 @default.
- W2100308045 hasConcept C126322002 @default.
- W2100308045 hasConcept C131453863 @default.
- W2100308045 hasConcept C148762608 @default.
- W2100308045 hasConcept C169760540 @default.
- W2100308045 hasConcept C170493617 @default.
- W2100308045 hasConcept C17077164 @default.
- W2100308045 hasConcept C178790620 @default.
- W2100308045 hasConcept C185592680 @default.
- W2100308045 hasConcept C2776108384 @default.
- W2100308045 hasConcept C2778186239 @default.
- W2100308045 hasConcept C2778437258 @default.
- W2100308045 hasConcept C57236427 @default.
- W2100308045 hasConcept C61174792 @default.
- W2100308045 hasConcept C66974803 @default.
- W2100308045 hasConcept C71924100 @default.
- W2100308045 hasConcept C86803240 @default.
- W2100308045 hasConceptScore W2100308045C112592302 @default.
- W2100308045 hasConceptScore W2100308045C126322002 @default.
- W2100308045 hasConceptScore W2100308045C131453863 @default.
- W2100308045 hasConceptScore W2100308045C148762608 @default.
- W2100308045 hasConceptScore W2100308045C169760540 @default.
- W2100308045 hasConceptScore W2100308045C170493617 @default.
- W2100308045 hasConceptScore W2100308045C17077164 @default.
- W2100308045 hasConceptScore W2100308045C178790620 @default.
- W2100308045 hasConceptScore W2100308045C185592680 @default.
- W2100308045 hasConceptScore W2100308045C2776108384 @default.
- W2100308045 hasConceptScore W2100308045C2778186239 @default.
- W2100308045 hasConceptScore W2100308045C2778437258 @default.
- W2100308045 hasConceptScore W2100308045C57236427 @default.
- W2100308045 hasConceptScore W2100308045C61174792 @default.
- W2100308045 hasConceptScore W2100308045C66974803 @default.
- W2100308045 hasConceptScore W2100308045C71924100 @default.
- W2100308045 hasConceptScore W2100308045C86803240 @default.
- W2100308045 hasIssue "2" @default.
- W2100308045 hasLocation W21003080451 @default.
- W2100308045 hasLocation W21003080452 @default.
- W2100308045 hasLocation W21003080453 @default.
- W2100308045 hasLocation W21003080454 @default.
- W2100308045 hasOpenAccess W2100308045 @default.
- W2100308045 hasPrimaryLocation W21003080451 @default.
- W2100308045 hasRelatedWork W1963621158 @default.
- W2100308045 hasRelatedWork W2010233362 @default.
- W2100308045 hasRelatedWork W2010386501 @default.
- W2100308045 hasRelatedWork W2044536248 @default.
- W2100308045 hasRelatedWork W2046999866 @default.
- W2100308045 hasRelatedWork W2115853505 @default.
- W2100308045 hasRelatedWork W2130347268 @default.
- W2100308045 hasRelatedWork W2267366329 @default.
- W2100308045 hasRelatedWork W2323795706 @default.
- W2100308045 hasRelatedWork W2610785804 @default.
- W2100308045 hasVolume "10" @default.
- W2100308045 isParatext "false" @default.
- W2100308045 isRetracted "false" @default.
- W2100308045 magId "2100308045" @default.
- W2100308045 workType "article" @default.