FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100336836> ?p ?o ?g. }

• W2100336836 endingPage "1487" @default.
• W2100336836 startingPage "1473" @default.
• W2100336836 abstract "Cytomegalovirus (CMV) is a significant opportunistic pathogen associated with AIDS and immunosuppressive therapy. Infection of the mature central nervous system (CNS) can cause significant pathology with associated neurological deficits, mental disorders, and cognitive impairment and may have potentially fatal consequences. Using genetically immunocompromised mice, we studied mechanisms of CMV invasion into, and behavior within, the CNS. Adult immunodeficient (nude and SCID) and control mice were peripherally infected with recombinant mouse CMV expressing a green fluorescent protein reporter gene. Control mice actively eliminated acute peripheral infection and were resistant to invasion of CMV into the brain. In contrast, virus infected brains of immunodeficient mice but only after a minimum of 21 days postinoculation. After inoculation, CMV was found in circulating leukocytes (MAC-3/CD45(+)) and in leukocytes within the brain, suggesting these cells as a possible source of CMV entry into the CNS. CNS infection was observed in many different cell types, including neurons, glial cells, meninges, ependymal cells, and cells of cerebral vessels. Infection foci progressively expanded locally to adjacent cells, resulting in meningitis, choroiditis, encephalitis, vasculitis, and necrosis; clear indication of axonal transport of CMV was not found. Regional distribution of CMV was unique in each brain, consisting of randomly distributed, unilateral foci. Testing whether CMV gained access to brain through nonspecific vascular disruption, vascular injections of a tracer molecule revealed no obvious disruption of the blood brain barrier in mice with CMV in the brain. Results indicate the importance of host adaptive immunity (particularly T cells) in controlling entry and dissemination of CMV into the brain and are consistent with the view that virus may be carried into the brain by circulating mononuclear cells that traffic through the blood brain barrier." @default.
• W2100336836 created "2016-06-24" @default.
• W2100336836 creator A5003486745 @default.
• W2100336836 creator A5004172478 @default.
• W2100336836 creator A5034065902 @default.
• W2100336836 creator A5046990042 @default.
• W2100336836 date "2004-02-01" @default.
• W2100336836 modified "2023-09-23" @default.
• W2100336836 title "Systemic Immune Deficiency Necessary for Cytomegalovirus Invasion of the Mature Brain" @default.
• W2100336836 cites W147173588 @default.
• W2100336836 cites W1539529772 @default.
• W2100336836 cites W1587702035 @default.
• W2100336836 cites W1655649919 @default.
• W2100336836 cites W1815236936 @default.
• W2100336836 cites W1909179079 @default.
• W2100336836 cites W1929174068 @default.
• W2100336836 cites W1965035454 @default.
• W2100336836 cites W1965696621 @default.
• W2100336836 cites W1967933941 @default.
• W2100336836 cites W1969526002 @default.
• W2100336836 cites W1974060304 @default.
• W2100336836 cites W1976623136 @default.
• W2100336836 cites W1978030615 @default.
• W2100336836 cites W1980147683 @default.
• W2100336836 cites W1982833488 @default.
• W2100336836 cites W1989877475 @default.
• W2100336836 cites W2004566606 @default.
• W2100336836 cites W2007059696 @default.
• W2100336836 cites W2022520883 @default.
• W2100336836 cites W2035035336 @default.
• W2100336836 cites W2035295249 @default.
• W2100336836 cites W2045367932 @default.
• W2100336836 cites W2045598092 @default.
• W2100336836 cites W2046547517 @default.
• W2100336836 cites W2048393315 @default.
• W2100336836 cites W2054518244 @default.
• W2100336836 cites W2059763100 @default.
• W2100336836 cites W2065623627 @default.
• W2100336836 cites W2067360995 @default.
• W2100336836 cites W2068635571 @default.
• W2100336836 cites W2071072160 @default.
• W2100336836 cites W2088054272 @default.
• W2100336836 cites W2088578770 @default.
• W2100336836 cites W2089794864 @default.
• W2100336836 cites W2110611572 @default.
• W2100336836 cites W2113652613 @default.
• W2100336836 cites W2120763191 @default.
• W2100336836 cites W2127730534 @default.
• W2100336836 cites W2133813100 @default.
• W2100336836 cites W2139314005 @default.
• W2100336836 cites W2317099057 @default.
• W2100336836 cites W2412012288 @default.
• W2100336836 cites W4290345012 @default.
• W2100336836 cites W8749802 @default.
• W2100336836 cites W89912017 @default.
• W2100336836 cites W2336506829 @default.
• W2100336836 cites W2416737478 @default.
• W2100336836 cites W4252028542 @default.
• W2100336836 doi "https://doi.org/10.1128/jvi.78.3.1473-1487.2004" @default.
• W2100336836 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/321365" @default.
• W2100336836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14722303" @default.
• W2100336836 hasPublicationYear "2004" @default.
• W2100336836 type Work @default.
• W2100336836 sameAs 2100336836 @default.
• W2100336836 citedByCount "51" @default.
• W2100336836 countsByYear W21003368362012 @default.
• W2100336836 countsByYear W21003368362014 @default.
• W2100336836 countsByYear W21003368362015 @default.
• W2100336836 countsByYear W21003368362016 @default.
• W2100336836 countsByYear W21003368362017 @default.
• W2100336836 countsByYear W21003368362018 @default.
• W2100336836 countsByYear W21003368362019 @default.
• W2100336836 countsByYear W21003368362020 @default.
• W2100336836 countsByYear W21003368362021 @default.
• W2100336836 countsByYear W21003368362022 @default.
• W2100336836 crossrefType "journal-article" @default.
• W2100336836 hasAuthorship W2100336836A5003486745 @default.
• W2100336836 hasAuthorship W2100336836A5004172478 @default.
• W2100336836 hasAuthorship W2100336836A5034065902 @default.
• W2100336836 hasAuthorship W2100336836A5046990042 @default.
• W2100336836 hasBestOaLocation W21003368361 @default.
• W2100336836 hasConcept C142724271 @default.
• W2100336836 hasConcept C159047783 @default.
• W2100336836 hasConcept C169760540 @default.
• W2100336836 hasConcept C203014093 @default.
• W2100336836 hasConcept C2522874641 @default.
• W2100336836 hasConcept C2776409557 @default.
• W2100336836 hasConcept C2777732132 @default.
• W2100336836 hasConcept C2778402981 @default.
• W2100336836 hasConcept C2778529815 @default.
• W2100336836 hasConcept C2780727368 @default.
• W2100336836 hasConcept C529278444 @default.
• W2100336836 hasConcept C71924100 @default.
• W2100336836 hasConcept C83455156 @default.
• W2100336836 hasConcept C86803240 @default.
• W2100336836 hasConcept C8891405 @default.
• W2100336836 hasConceptScore W2100336836C142724271 @default.
• W2100336836 hasConceptScore W2100336836C159047783 @default.

• next