Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100348740> ?p ?o ?g. }
- W2100348740 endingPage "e20690" @default.
- W2100348740 startingPage "e20690" @default.
- W2100348740 abstract "Background Suicidal behaviour can be conceptualised as a continuum from suicidal ideation, to suicidal attempts to completed suicide. In this study we identify genes contributing to suicidal behaviour in the depression study RADIANT. Methodology/Principal Findings A quantitative suicidality score was composed of two items from the SCAN interview. In addition, the 251 depression cases with a history of serious suicide attempts were classified to form a discrete trait. The quantitative trait was correlated with younger onset of depression and number of episodes of depression, but not with gender. A genome-wide association study of 2,023 depression cases was performed to identify genes that may contribute to suicidal behaviour. Two Munich depression studies were used as replication cohorts to test the most strongly associated SNPs. No SNP was associated at genome-wide significance level. For the quantitative trait, evidence of association was detected at GFRA1, a receptor for the neurotrophin GDRA (p = 2e-06). For the discrete trait of suicide attempt, SNPs in KIAA1244 and RGS18 attained p-values of <5e-6. None of these SNPs showed evidence for replication in the additional cohorts tested. Candidate gene analysis provided some support for a polymorphism in NTRK2, which was previously associated with suicidality. Conclusions/Significance This study provides a genome-wide assessment of possible genetic contribution to suicidal behaviour in depression but indicates a genetic architecture of multiple genes with small effects. Large cohorts will be required to dissect this further." @default.
- W2100348740 created "2016-06-24" @default.
- W2100348740 creator A5002321122 @default.
- W2100348740 creator A5006541865 @default.
- W2100348740 creator A5007752410 @default.
- W2100348740 creator A5015327943 @default.
- W2100348740 creator A5015772002 @default.
- W2100348740 creator A5017312170 @default.
- W2100348740 creator A5018800732 @default.
- W2100348740 creator A5020397716 @default.
- W2100348740 creator A5026352442 @default.
- W2100348740 creator A5029723036 @default.
- W2100348740 creator A5033696898 @default.
- W2100348740 creator A5036151135 @default.
- W2100348740 creator A5036308969 @default.
- W2100348740 creator A5037140624 @default.
- W2100348740 creator A5041323025 @default.
- W2100348740 creator A5044356203 @default.
- W2100348740 creator A5045289228 @default.
- W2100348740 creator A5045733970 @default.
- W2100348740 creator A5045978641 @default.
- W2100348740 creator A5050995972 @default.
- W2100348740 creator A5053789268 @default.
- W2100348740 creator A5056948570 @default.
- W2100348740 creator A5068135840 @default.
- W2100348740 creator A5074716536 @default.
- W2100348740 creator A5078325033 @default.
- W2100348740 creator A5079385332 @default.
- W2100348740 creator A5084729995 @default.
- W2100348740 creator A5086814680 @default.
- W2100348740 creator A5088866740 @default.
- W2100348740 creator A5091088506 @default.
- W2100348740 date "2011-07-05" @default.
- W2100348740 modified "2023-10-12" @default.
- W2100348740 title "Genomewide Association Scan of Suicidal Thoughts and Behaviour in Major Depression" @default.
- W2100348740 cites W1794781721 @default.
- W2100348740 cites W1970174523 @default.
- W2100348740 cites W1973974781 @default.
- W2100348740 cites W1975762831 @default.
- W2100348740 cites W1979894286 @default.
- W2100348740 cites W1998266756 @default.
- W2100348740 cites W1998882379 @default.
- W2100348740 cites W2007588978 @default.
- W2100348740 cites W2008047653 @default.
- W2100348740 cites W2021296114 @default.
- W2100348740 cites W2023634568 @default.
- W2100348740 cites W2023768544 @default.
- W2100348740 cites W2026674733 @default.
- W2100348740 cites W2030705868 @default.
- W2100348740 cites W2037383099 @default.
- W2100348740 cites W2045333532 @default.
- W2100348740 cites W2046215972 @default.
- W2100348740 cites W2051065925 @default.
- W2100348740 cites W2054219118 @default.
- W2100348740 cites W2056551165 @default.
- W2100348740 cites W2068500609 @default.
- W2100348740 cites W2068995113 @default.
- W2100348740 cites W2075975982 @default.
- W2100348740 cites W2084399551 @default.
- W2100348740 cites W2084865691 @default.
- W2100348740 cites W2098541233 @default.
- W2100348740 cites W2098978408 @default.
- W2100348740 cites W2105239414 @default.
- W2100348740 cites W2107755054 @default.
- W2100348740 cites W2115256844 @default.
- W2100348740 cites W2126718294 @default.
- W2100348740 cites W2135718110 @default.
- W2100348740 cites W2145584780 @default.
- W2100348740 cites W2150633664 @default.
- W2100348740 cites W2151392013 @default.
- W2100348740 cites W2155662148 @default.
- W2100348740 cites W2157752701 @default.
- W2100348740 cites W2161633633 @default.
- W2100348740 cites W2162633534 @default.
- W2100348740 cites W2339186961 @default.
- W2100348740 cites W4376635361 @default.
- W2100348740 doi "https://doi.org/10.1371/journal.pone.0020690" @default.
- W2100348740 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3130038" @default.
- W2100348740 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21750702" @default.
- W2100348740 hasPublicationYear "2011" @default.
- W2100348740 type Work @default.
- W2100348740 sameAs 2100348740 @default.
- W2100348740 citedByCount "100" @default.
- W2100348740 countsByYear W21003487402012 @default.
- W2100348740 countsByYear W21003487402013 @default.
- W2100348740 countsByYear W21003487402014 @default.
- W2100348740 countsByYear W21003487402015 @default.
- W2100348740 countsByYear W21003487402016 @default.
- W2100348740 countsByYear W21003487402017 @default.
- W2100348740 countsByYear W21003487402018 @default.
- W2100348740 countsByYear W21003487402019 @default.
- W2100348740 countsByYear W21003487402020 @default.
- W2100348740 countsByYear W21003487402021 @default.
- W2100348740 countsByYear W21003487402022 @default.
- W2100348740 countsByYear W21003487402023 @default.
- W2100348740 crossrefType "journal-article" @default.
- W2100348740 hasAuthorship W2100348740A5002321122 @default.
- W2100348740 hasAuthorship W2100348740A5006541865 @default.