FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100353955> ?p ?o ?g. }

• W2100353955 endingPage "7218" @default.
• W2100353955 startingPage "7214" @default.
• W2100353955 abstract "We have examined the metabolism of ketone bodies in neuroblastoma C1300 and glioma C6 cells, two established lines of neural origin. The three ketone body-metabolizing enzymes are present in cells of both lines in the relative proportions normally found in brain (D-3-hydroxybutyrate dehydrogenase less than acetoacetyl-CoA thiolase less than 3-ketoacid CoA-transferase), the activities of the first two are higher in glioma cells than in neuroblastoma, and that of the third is 2-fold higher in neuroblastoma cells than in glioma cells. The specific activity of 3-ketoacid CoA-transferase (EC 2.8.3.5) in both cell lines increased as the cultures achieved confluence, then decreased. Ketone bodies and especially acetoacetate are preferred substrates for synthesis of neural lipids in cells of both lines. The incorporation of glucose carbon into lipids is significantly reduced in cells of both lines in the presence of ketone bodies. Addition of acetoacetate but not DL-3-hydroxybutyrate to the culture medium resulted in a significant increase in the activity of 3-ketoacid CoA-transferase and also in the rate of acetoacetate oxidation in neuroblastoma cells but not glioma cells. These findings indicate that specific differences exist in the capacity of these two cell lines to metabolize ketone bodies and also that substrate-level regulation of the ketone body-metabolizing pathway exists. These two lines therefore provide a potentially useful system in which the mechanisms of regulation of these enzymes may be examined." @default.
• W2100353955 created "2016-06-24" @default.
• W2100353955 creator A5014485935 @default.
• W2100353955 creator A5031882326 @default.
• W2100353955 creator A5073619227 @default.
• W2100353955 date "1981-11-01" @default.
• W2100353955 modified "2023-09-27" @default.
• W2100353955 title "Ketone-body metabolism in glioma and neuroblastoma cells." @default.
• W2100353955 cites W1520595698 @default.
• W2100353955 cites W1560125983 @default.
• W2100353955 cites W162162663 @default.
• W2100353955 cites W1775749144 @default.
• W2100353955 cites W1827211888 @default.
• W2100353955 cites W1938553409 @default.
• W2100353955 cites W1978960237 @default.
• W2100353955 cites W2001170144 @default.
• W2100353955 cites W2014063107 @default.
• W2100353955 cites W2015180485 @default.
• W2100353955 cites W2047565640 @default.
• W2100353955 cites W2047745796 @default.
• W2100353955 cites W2073964453 @default.
• W2100353955 cites W2075905368 @default.
• W2100353955 cites W2096022018 @default.
• W2100353955 cites W2105546244 @default.
• W2100353955 cites W2133392181 @default.
• W2100353955 cites W2145615169 @default.
• W2100353955 cites W2237527515 @default.
• W2100353955 cites W2334948198 @default.
• W2100353955 cites W2338209918 @default.
• W2100353955 cites W2342227032 @default.
• W2100353955 cites W33574795 @default.
• W2100353955 cites W4234372716 @default.
• W2100353955 doi "https://doi.org/10.1073/pnas.78.11.7214" @default.
• W2100353955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/349227" @default.
• W2100353955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6118869" @default.
• W2100353955 hasPublicationYear "1981" @default.
• W2100353955 type Work @default.
• W2100353955 sameAs 2100353955 @default.
• W2100353955 citedByCount "26" @default.
• W2100353955 countsByYear W21003539552012 @default.
• W2100353955 countsByYear W21003539552013 @default.
• W2100353955 countsByYear W21003539552015 @default.
• W2100353955 countsByYear W21003539552016 @default.
• W2100353955 countsByYear W21003539552018 @default.
• W2100353955 countsByYear W21003539552019 @default.
• W2100353955 countsByYear W21003539552022 @default.
• W2100353955 countsByYear W21003539552023 @default.
• W2100353955 crossrefType "journal-article" @default.
• W2100353955 hasAuthorship W2100353955A5014485935 @default.
• W2100353955 hasAuthorship W2100353955A5031882326 @default.
• W2100353955 hasAuthorship W2100353955A5073619227 @default.
• W2100353955 hasBestOaLocation W21003539551 @default.
• W2100353955 hasConcept C178790620 @default.
• W2100353955 hasConcept C181199279 @default.
• W2100353955 hasConcept C185592680 @default.
• W2100353955 hasConcept C2776317432 @default.
• W2100353955 hasConcept C2776715637 @default.
• W2100353955 hasConcept C2777738585 @default.
• W2100353955 hasConcept C2778227246 @default.
• W2100353955 hasConcept C2781031557 @default.
• W2100353955 hasConcept C31532488 @default.
• W2100353955 hasConcept C502942594 @default.
• W2100353955 hasConcept C54355233 @default.
• W2100353955 hasConcept C55493867 @default.
• W2100353955 hasConcept C62231903 @default.
• W2100353955 hasConcept C81885089 @default.
• W2100353955 hasConcept C86803240 @default.
• W2100353955 hasConceptScore W2100353955C178790620 @default.
• W2100353955 hasConceptScore W2100353955C181199279 @default.
• W2100353955 hasConceptScore W2100353955C185592680 @default.
• W2100353955 hasConceptScore W2100353955C2776317432 @default.
• W2100353955 hasConceptScore W2100353955C2776715637 @default.
• W2100353955 hasConceptScore W2100353955C2777738585 @default.
• W2100353955 hasConceptScore W2100353955C2778227246 @default.
• W2100353955 hasConceptScore W2100353955C2781031557 @default.
• W2100353955 hasConceptScore W2100353955C31532488 @default.
• W2100353955 hasConceptScore W2100353955C502942594 @default.
• W2100353955 hasConceptScore W2100353955C54355233 @default.
• W2100353955 hasConceptScore W2100353955C55493867 @default.
• W2100353955 hasConceptScore W2100353955C62231903 @default.
• W2100353955 hasConceptScore W2100353955C81885089 @default.
• W2100353955 hasConceptScore W2100353955C86803240 @default.
• W2100353955 hasIssue "11" @default.
• W2100353955 hasLocation W21003539551 @default.
• W2100353955 hasLocation W21003539552 @default.
• W2100353955 hasLocation W21003539553 @default.
• W2100353955 hasLocation W21003539554 @default.
• W2100353955 hasOpenAccess W2100353955 @default.
• W2100353955 hasPrimaryLocation W21003539551 @default.
• W2100353955 hasRelatedWork W1599448530 @default.
• W2100353955 hasRelatedWork W190789117 @default.
• W2100353955 hasRelatedWork W2044373816 @default.
• W2100353955 hasRelatedWork W2049454509 @default.
• W2100353955 hasRelatedWork W2074411392 @default.
• W2100353955 hasRelatedWork W2100353955 @default.
• W2100353955 hasRelatedWork W2135906727 @default.
• W2100353955 hasRelatedWork W2155801632 @default.
• W2100353955 hasRelatedWork W2345870232 @default.

• next