FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100359846> ?p ?o ?g. }

• W2100359846 endingPage "E268" @default.
• W2100359846 startingPage "E262" @default.
• W2100359846 abstract "Androgen exposure during intrauterine life in nonhuman primates and in sheep results in a phenocopy of the reproductive and metabolic features of polycystic ovary syndrome (PCOS). Such exposure also results in reproductive features of PCOS in rodents. We investigated whether transient prenatal androgen treatment produced metabolic abnormalities in adult female rats and the mechanisms of these changes. Pregnant dams received free testosterone or vehicle injections during late gestation, and their female offspring were fed regular or high-fat diet (HFD). At 60 days of age, prenatally androgenized (PA) rats exhibited significantly increased body weight; parametrial and subcutaneous fat; serum insulin, cholesterol and triglyceride levels; and hepatic triglyceride content (all P < 0.0125). There were no significant differences in insulin sensitivity by intraperitoneal insulin tolerance test or insulin signaling in liver or skeletal muscle. HFD had similar effects to PA on body weight and composition as well as on circulating triglyceride levels. HFD further increased hepatic triglyceride content to a similar extent in both PA and control rats. In PA rats, HFD did not further increase circulating insulin, triglyceride, or cholesterol levels. In control rats, HFD increased insulin levels, but to a lesser extent than PA alone ( approximately 2.5- vs. approximately 12-fold, respectively). We conclude that transient prenatal androgen exposure produces features of the metabolic syndrome in adult female rats. Dyslipidemia and hepatic steatosis appear to be mediated by PA-induced increases in adiposity, whereas hyperinsulinemia appears to be a direct result of PA." @default.
• W2100359846 created "2016-06-24" @default.
• W2100359846 creator A5003466066 @default.
• W2100359846 creator A5006530708 @default.
• W2100359846 creator A5014769599 @default.
• W2100359846 creator A5039440110 @default.
• W2100359846 creator A5057491998 @default.
• W2100359846 creator A5059473016 @default.
• W2100359846 date "2008-08-01" @default.
• W2100359846 modified "2023-10-13" @default.
• W2100359846 title "Transient prenatal androgen exposure produces metabolic syndrome in adult female rats" @default.
• W2100359846 cites W1965019847 @default.
• W2100359846 cites W1967564560 @default.
• W2100359846 cites W1972008706 @default.
• W2100359846 cites W1977797609 @default.
• W2100359846 cites W1981668249 @default.
• W2100359846 cites W1995000970 @default.
• W2100359846 cites W2005004639 @default.
• W2100359846 cites W2014108789 @default.
• W2100359846 cites W2016293185 @default.
• W2100359846 cites W2026854030 @default.
• W2100359846 cites W2035924698 @default.
• W2100359846 cites W2039840029 @default.
• W2100359846 cites W2040629057 @default.
• W2100359846 cites W2046866637 @default.
• W2100359846 cites W2047492902 @default.
• W2100359846 cites W2051894323 @default.
• W2100359846 cites W2053731484 @default.
• W2100359846 cites W2061560405 @default.
• W2100359846 cites W2065794163 @default.
• W2100359846 cites W2068027453 @default.
• W2100359846 cites W2078094750 @default.
• W2100359846 cites W2094587210 @default.
• W2100359846 cites W2113151874 @default.
• W2100359846 cites W2114291118 @default.
• W2100359846 cites W2123009569 @default.
• W2100359846 cites W2127124396 @default.
• W2100359846 cites W2136496059 @default.
• W2100359846 cites W2138910558 @default.
• W2100359846 cites W2139787576 @default.
• W2100359846 cites W2141630823 @default.
• W2100359846 cites W2148334712 @default.
• W2100359846 cites W2155530831 @default.
• W2100359846 cites W2155676752 @default.
• W2100359846 cites W2157268169 @default.
• W2100359846 cites W2158694949 @default.
• W2100359846 cites W2170810572 @default.
• W2100359846 cites W2185118008 @default.
• W2100359846 cites W2304042454 @default.
• W2100359846 cites W4211231448 @default.
• W2100359846 cites W4233283912 @default.
• W2100359846 doi "https://doi.org/10.1152/ajpendo.90208.2008" @default.
• W2100359846 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2519755" @default.
• W2100359846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18544644" @default.
• W2100359846 hasPublicationYear "2008" @default.
• W2100359846 type Work @default.
• W2100359846 sameAs 2100359846 @default.
• W2100359846 citedByCount "118" @default.
• W2100359846 countsByYear W21003598462012 @default.
• W2100359846 countsByYear W21003598462013 @default.
• W2100359846 countsByYear W21003598462014 @default.
• W2100359846 countsByYear W21003598462015 @default.
• W2100359846 countsByYear W21003598462016 @default.
• W2100359846 countsByYear W21003598462017 @default.
• W2100359846 countsByYear W21003598462018 @default.
• W2100359846 countsByYear W21003598462019 @default.
• W2100359846 countsByYear W21003598462020 @default.
• W2100359846 countsByYear W21003598462021 @default.
• W2100359846 countsByYear W21003598462022 @default.
• W2100359846 countsByYear W21003598462023 @default.
• W2100359846 crossrefType "journal-article" @default.
• W2100359846 hasAuthorship W2100359846A5003466066 @default.
• W2100359846 hasAuthorship W2100359846A5006530708 @default.
• W2100359846 hasAuthorship W2100359846A5014769599 @default.
• W2100359846 hasAuthorship W2100359846A5039440110 @default.
• W2100359846 hasAuthorship W2100359846A5057491998 @default.
• W2100359846 hasAuthorship W2100359846A5059473016 @default.
• W2100359846 hasBestOaLocation W21003598462 @default.
• W2100359846 hasConcept C112672928 @default.
• W2100359846 hasConcept C126322002 @default.
• W2100359846 hasConcept C134018914 @default.
• W2100359846 hasConcept C2777391703 @default.
• W2100359846 hasConcept C2777911890 @default.
• W2100359846 hasConcept C2778096610 @default.
• W2100359846 hasConcept C2778163477 @default.
• W2100359846 hasConcept C2778913445 @default.
• W2100359846 hasConcept C2779234561 @default.
• W2100359846 hasConcept C2779279991 @default.
• W2100359846 hasConcept C2779306644 @default.
• W2100359846 hasConcept C2780578515 @default.
• W2100359846 hasConcept C2780988686 @default.
• W2100359846 hasConcept C3018442814 @default.
• W2100359846 hasConcept C54355233 @default.
• W2100359846 hasConcept C555293320 @default.
• W2100359846 hasConcept C71315377 @default.
• W2100359846 hasConcept C71924100 @default.
• W2100359846 hasConcept C86803240 @default.
• W2100359846 hasConceptScore W2100359846C112672928 @default.

• next