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• W2100360003 abstract "This study investigated whether reduced glutathione (GSH) was able to alter the negative effects of tributyltin (TBT) or dibutyltin (DBT) on the lytic function of human natural killer (NK) cells. NK cells are an initial immune defense against the development of tumors or viral infections. TBT and DBT are widespread environmental contaminants, due to their various industrial applications. Both TBT and DBT have been shown to decrease the ability of NK cells to lyse tumor cells (lytic function). The results indicated that the presence of GSH during the exposure of NK cells to TBT or DBT diminished the negative effect of the butyltin on the lytic function of NK cells. This suggests that the interaction of TBT and DBT with functionally relevant sulfhydryl groups in NK cells may be part of the mechanism by which they decrease NK lytic function." @default.
• W2100360003 created "2016-06-24" @default.
• W2100360003 creator A5040860241 @default.
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• W2100360003 date "2009-01-01" @default.
• W2100360003 modified "2023-09-24" @default.
• W2100360003 title "Glutathione diminishes tributyltin- and dibutyltin-induced loss of lytic function in human natural killer cells" @default.
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• W2100360003 doi "https://doi.org/10.1080/01480540802416000" @default.
• W2100360003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2704261" @default.
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