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- W2100367705 endingPage "2081" @default.
- W2100367705 startingPage "2074" @default.
- W2100367705 abstract "An increased plasma homocysteine level is an independent risk factor for vascular disease. However, the pathological mechanisms by which homocysteine promotes atherosclerosis are not yet clearly defined. Arterial smooth muscle cells cultured in the presence of homocysteine grew to a higher density and produced and accumulated collagen at levels significantly above control values. Homocysteine concentrations as low as 50 mumol/L significantly increased both cell density and collagen production. Cell density increased by as much as 43% in homocysteine-treated cultures. Homocysteine increased collagen production in a dose-dependent manner. Smooth muscle cells treated with homocysteine at concentrations observed in patients with hyperhomocysteinemia had collagen synthesis rates as high as 214% of control values. Likewise, collagen accumulation in the cell layer was nearly doubled in homocysteine-treated cultures. Addition of aquacobalamin to homocysteine-treated cultures controlled the increase in smooth muscle cell proliferation and collagen production. These results indicate a cellular mechanism for the atherogenicity of homocysteine and provide insight into a potential preventive treatment." @default.
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- W2100367705 date "1997-10-01" @default.
- W2100367705 modified "2023-10-10" @default.
- W2100367705 title "Homocysteine as a Risk Factor for Vascular Disease" @default.
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- W2100367705 doi "https://doi.org/10.1161/01.atv.17.10.2074" @default.
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