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- W2100369719 abstract "The past generation has witnessed a surge in the number of children, adolescents, and young adults with type 2 diabetes (1–3). In most cases the illness begins with excess weight gain, insulin resistance, and dyslipidemia and progresses through a stage of fasting or postprandial hyperglycemia [impaired glucose tolerance (IGT)] before the emergence of clinical symptoms (4). IGT, dyslipidemia, and overt type 2 diabetes predispose to hepatic steatosis and microvascular and macrovascular complications, which may arise early in the course of the illness (5–9). The threat of vascular and hepatic complications makes the prevention of type 2 diabetes of paramount importance. Recent studies delineate risk factors for the development of type 2 diabetes in children and young adults. Chief among these are poorly defined genetic factors, ethnic background, and obesity (1–3). Rates of type 2 diabetes increase with age, as puberty is associated with a decline in insulin sensitivity (1–4). In the prodromal state, the risk of diabetes is highest among obese patients with severe insulin resistance and fasting or postprandial hyperglycemia. Emerging evidence suggests that lifestyle intervention and pharmacotherapy may reduce the rates of development of type 2 diabetes in subjects at highest risk (see below). This manuscript summarizes current views of the pathogenesis of type 2 diabetes in children and adolescents and discusses potential roles for pharmacological agents in the prevention of diabetes in high risk subjects." @default.
- W2100369719 created "2016-06-24" @default.
- W2100369719 creator A5080509236 @default.
- W2100369719 date "2003-01-01" @default.
- W2100369719 modified "2023-09-27" @default.
- W2100369719 title "Pharmacologic Approaches to the Prevention of Type 2 Diabetes in High Risk Pediatric Patients" @default.
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