FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100380053> ?p ?o ?g. }

• W2100380053 endingPage "64" @default.
• W2100380053 startingPage "57" @default.
• W2100380053 abstract "Objectives: After ischaemic preconditioning (IP), obtained by short episodes of ischaemia, cardiac protection occurs due to a reduction in myocardial metabolism through the activation of A1 adenosine receptors. The antiarrhythmic effect of IP is attributed to an increase in the release of nitric oxide (NO) by the endothelium. On the basis of the above consideration the present investigation studies the changes induced by preconditioning in coronary reactive hyperaemia (RH) and how blockade of A1 receptors and inhibition of NO synthesis can modify these changes. Methods: In anaesthetised goats, an electromagnetic flow-probe was placed around the left circumflex coronary artery. Preconditioning was obtained with two episodes of 2.5 min of coronary occlusion, separated by 5 min of reperfusion. RH was obtained with a 15 s occlusion. In a control group (n=7) RH was studied before and after IP. In a second group (n=7), 0.2 mg kg−1 of 8-cyclopentyl-dipropylxanthine, an A1 receptor blocker, and in a third group (n=7) 10 mg kg−1 of NG-nitro-l-arginine (LNNA), an NO inhibitor, were given before IP. Reactive hyperaemia was again obtained before and after IP. Results: In the control group, after IP, the time to peak hyperaemic flow and total hyperaemic flow decreased by about 50% and 25%, respectively. The A1 receptor blockade alone did not change RH. During A1 blockade, IP reduced the time to peak of RH similar as in control (45%), but did not alter total hyperaemic flow. LNNA alone reduced resting flow and total hyperaemic flow. After NO inhibition, IP only reduced total hyperaemic flow by about 15%, but the time to peak flow was not affected. Conclusions: IP alters RH by decreasing total hyperaemic flow and reducing the time to peak hyperaemic flow. While the former effect is attributed to a reduction in myocardial metabolism through the activation of the A1 receptors, the latter is likely to be due to an increased endothelial release of NO, suggesting that in addition to a protective effect on the myocardium, IP also exerts a direct effect on the responsiveness of the coronary vasculature (vascular preconditioning)." @default.
• W2100380053 created "2016-06-24" @default.
• W2100380053 creator A5034204870 @default.
• W2100380053 creator A5045025514 @default.
• W2100380053 creator A5053681711 @default.
• W2100380053 creator A5053750438 @default.
• W2100380053 creator A5064385767 @default.
• W2100380053 date "1999-04-01" @default.
• W2100380053 modified "2023-10-18" @default.
• W2100380053 title "Ischaemic preconditioning changes the pattern of coronary reactive hyperaemia in the goat: role of adenosine and nitric oxide" @default.
• W2100380053 cites W169179504 @default.
• W2100380053 cites W1966045944 @default.
• W2100380053 cites W1968879284 @default.
• W2100380053 cites W1971434885 @default.
• W2100380053 cites W1977995230 @default.
• W2100380053 cites W1978842162 @default.
• W2100380053 cites W1983991598 @default.
• W2100380053 cites W1987988213 @default.
• W2100380053 cites W1995025667 @default.
• W2100380053 cites W2008682907 @default.
• W2100380053 cites W2015324695 @default.
• W2100380053 cites W2016627878 @default.
• W2100380053 cites W2029967055 @default.
• W2100380053 cites W2037867131 @default.
• W2100380053 cites W2062202508 @default.
• W2100380053 cites W2073242964 @default.
• W2100380053 cites W2081048275 @default.
• W2100380053 cites W2083611167 @default.
• W2100380053 cites W2087376661 @default.
• W2100380053 cites W2098218378 @default.
• W2100380053 cites W2098375846 @default.
• W2100380053 cites W2100770709 @default.
• W2100380053 cites W2106057349 @default.
• W2100380053 cites W2153035007 @default.
• W2100380053 cites W2170152286 @default.
• W2100380053 cites W2317498119 @default.
• W2100380053 cites W2395752971 @default.
• W2100380053 cites W2396031423 @default.
• W2100380053 cites W2409585736 @default.
• W2100380053 cites W2433775949 @default.
• W2100380053 cites W2439982346 @default.
• W2100380053 cites W2472944785 @default.
• W2100380053 cites W2473897049 @default.
• W2100380053 doi "https://doi.org/10.1016/s0008-6363(98)00319-8" @default.
• W2100380053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10434996" @default.
• W2100380053 hasPublicationYear "1999" @default.
• W2100380053 type Work @default.
• W2100380053 sameAs 2100380053 @default.
• W2100380053 citedByCount "40" @default.
• W2100380053 countsByYear W21003800532012 @default.
• W2100380053 countsByYear W21003800532013 @default.
• W2100380053 countsByYear W21003800532014 @default.
• W2100380053 countsByYear W21003800532015 @default.
• W2100380053 countsByYear W21003800532016 @default.
• W2100380053 countsByYear W21003800532017 @default.
• W2100380053 countsByYear W21003800532018 @default.
• W2100380053 countsByYear W21003800532019 @default.
• W2100380053 countsByYear W21003800532020 @default.
• W2100380053 countsByYear W21003800532021 @default.
• W2100380053 countsByYear W21003800532022 @default.
• W2100380053 crossrefType "journal-article" @default.
• W2100380053 hasAuthorship W2100380053A5034204870 @default.
• W2100380053 hasAuthorship W2100380053A5045025514 @default.
• W2100380053 hasAuthorship W2100380053A5053681711 @default.
• W2100380053 hasAuthorship W2100380053A5053750438 @default.
• W2100380053 hasAuthorship W2100380053A5064385767 @default.
• W2100380053 hasBestOaLocation W21003800531 @default.
• W2100380053 hasConcept C120770815 @default.
• W2100380053 hasConcept C126322002 @default.
• W2100380053 hasConcept C158846371 @default.
• W2100380053 hasConcept C164705383 @default.
• W2100380053 hasConcept C170493617 @default.
• W2100380053 hasConcept C2776157398 @default.
• W2100380053 hasConcept C2776991684 @default.
• W2100380053 hasConcept C2777691872 @default.
• W2100380053 hasConcept C2778468042 @default.
• W2100380053 hasConcept C2778938600 @default.
• W2100380053 hasConcept C2779311647 @default.
• W2100380053 hasConcept C2780393670 @default.
• W2100380053 hasConcept C3019128504 @default.
• W2100380053 hasConcept C42219234 @default.
• W2100380053 hasConcept C519581460 @default.
• W2100380053 hasConcept C541997718 @default.
• W2100380053 hasConcept C67907053 @default.
• W2100380053 hasConcept C71924100 @default.
• W2100380053 hasConceptScore W2100380053C120770815 @default.
• W2100380053 hasConceptScore W2100380053C126322002 @default.
• W2100380053 hasConceptScore W2100380053C158846371 @default.
• W2100380053 hasConceptScore W2100380053C164705383 @default.
• W2100380053 hasConceptScore W2100380053C170493617 @default.
• W2100380053 hasConceptScore W2100380053C2776157398 @default.
• W2100380053 hasConceptScore W2100380053C2776991684 @default.
• W2100380053 hasConceptScore W2100380053C2777691872 @default.
• W2100380053 hasConceptScore W2100380053C2778468042 @default.
• W2100380053 hasConceptScore W2100380053C2778938600 @default.
• W2100380053 hasConceptScore W2100380053C2779311647 @default.
• W2100380053 hasConceptScore W2100380053C2780393670 @default.
• W2100380053 hasConceptScore W2100380053C3019128504 @default.

• next