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- W2100400633 abstract "Internal ribosome entry sites (IRESs) are powerful model systems to understand how the translation machinery can be manipulated by structured RNAs and for exploring inherent features of ribosome function. The intergenic region (IGR) IRESs from the Dicistroviridae family of viruses are structured RNAs that bind directly to the ribosome and initiate translation by co-opting the translation elongation cycle. These IRESs require an RNA pseudoknot that mimics a codon-anticodon interaction and contains a conformationally dynamic loop. We explored the role of this loop and found that both the length and sequence are essential for translation in different types of IGR IRESs and from diverse viruses. We found that loop 3 affects two discrete elongation factor-dependent steps in the IRES initiation mechanism. Our results show how the IRES directs multiple steps after 80S ribosome placement and highlights the often underappreciated significance of discrete conformationally dynamic elements within the context of structured RNAs." @default.
- W2100400633 created "2016-06-24" @default.
- W2100400633 creator A5000742587 @default.
- W2100400633 creator A5006205806 @default.
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- W2100400633 creator A5040861505 @default.
- W2100400633 creator A5060911389 @default.
- W2100400633 creator A5070812690 @default.
- W2100400633 creator A5082712375 @default.
- W2100400633 creator A5088072771 @default.
- W2100400633 date "2015-11-02" @default.
- W2100400633 modified "2023-10-12" @default.
- W2100400633 title "A dynamic RNA loop in an IRES affects multiple steps of elongation factor-mediated translation initiation" @default.
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