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- W2100421036 abstract "Over the lifespan of therapeutic proteins, from the point of biosynthesis to the complete clearance from tested subjects, they undergo various biological modifications. Therapeutic influences and molecular mechanisms of these modifications have been well appreciated for some while remained less understood for many. This paper has classified these modifications into multiple categories, according to their processing locations and enzymatic involvement during the trafficking events. It also focuses on the underlying mechanisms and structural-functional relationship between modifications and therapeutic properties. In addition, recent advances in protein engineering, cell line engineering, and process engineering, by exploring these complex cellular processes, are discussed and summarized, for improving functional characteristics and attributes of protein-based biopharmaceutical products." @default.
- W2100421036 created "2016-06-24" @default.
- W2100421036 creator A5007596635 @default.
- W2100421036 creator A5065159436 @default.
- W2100421036 date "2013-01-01" @default.
- W2100421036 modified "2023-10-10" @default.
- W2100421036 title "Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications" @default.
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